K01398                      KO                                     
matrix metalloproteinase-2 (gelatinase A) [EC:]
map01522  Endocrine resistance
map04670  Leukocyte transendothelial migration
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04926  Relaxin signaling pathway
map04933  AGE-RAGE signaling pathway in diabetic complications
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05219  Bladder cancer
map05415  Diabetic cardiomyopathy
map05418  Fluid shear stress and atherosclerosis
H00025  Penile cancer
H00028  Choriocarcinoma
H00472  Torg syndrome
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09152 Endocrine system
   04912 GnRH signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04915 Estrogen signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04926 Relaxin signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05205 Proteoglycans in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05415 Diabetic cardiomyopathy
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases  gelatinase A
     K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
HSA: 4313(MMP2)
PTR: 454094(MMP2)
PPS: 100970966(MMP2)
GGO: 101147102(MMP2)
PON: 100451667(MMP2)
NLE: 100597186(MMP2)
MCC: 698478(MMP2)
MCF: 101865544(MMP2)
CSAB: 103233007(MMP2)
CATY: 105588567(MMP2)
PANU: 101014166(MMP2)
TGE: 112613724(MMP2)
RRO: 104671481(MMP2)
RBB: 108531264(MMP2)
TFN: 117087797(MMP2)
PTEH: 111541252(MMP2)
CJC: 100387448(MMP2)
SBQ: 101042210(MMP2)
CSYR: 103272469(MMP2)
MMUR: 105866549(MMP2)
OGA: 100965003(MMP2)
MMU: 17390(Mmp2)
MCAL: 110299708(Mmp2)
MPAH: 110337240(Mmp2)
RNO: 81686(Mmp2)
MCOC: 116069868(Mmp2)
MUN: 110545189(Mmp2)
CGE: 100774744(Mmp2)
PLEU: 114694533(Mmp2)
NGI: 103731682(Mmp2)
HGL: 101696977(Mmp2)
CPOC: 100719361(Mmp2)
CCAN: 109690723(Mmp2)
DORD: 105994417(Mmp2)
DSP: 122116321(Mmp2)
OCU: 100009000(MMP2)
OPI: 101522382(MMP2)
TUP: 102483061(MMP2)
CFA: 403733(MMP2)
VVP: 112929621(MMP2)
VLG: 121498055(MMP2)
AML: 100476183(MMP2)
UMR: 103673901(MMP2)
UAH: 113252249(MMP2)
UAR: 123798414(MMP2)
ELK: 111157340
MPUF: 101675156(MMP2)
ORO: 101378425(MMP2)
EJU: 114204089(MMP2)
ZCA: 113936159(MMP2)
MLX: 118023778(MMP2)
FCA: 101098838(MMP2)
PYU: 121045318(MMP2)
PBG: 122494216(MMP2)
PTG: 102956398(MMP2)
PPAD: 109270907(MMP2)
AJU: 106973291(MMP2)
HHV: 120238088(MMP2)
BTA: 282872(MMP2)
BOM: 102269336(MMP2)
BIU: 109572595(MMP2)
BBUB: 102401701(MMP2)
CHX: 102184364(MMP2)
OAS: 443115(MMP2)
ODA: 120873204(MMP2)
CCAD: 122420084(MMP2)
SSC: 397391(MMP2)
CFR: 102521167(MMP2)
CBAI: 105075731(MMP2)
CDK: 105097506(MMP2)
BACU: 103016736(MMP2)
LVE: 103071760(MMP2)
OOR: 101275485(MMP2)
DLE: 111164984(MMP2)
PCAD: 102973920(MMP2)
PSIU: 116743436(MMP2)
ECB: 100033948(MMP2)
EPZ: 103553197(MMP2)
EAI: 106822484(MMP2)
MYB: 102260608(MMP2)
MYD: 102767174(MMP2)
MMYO: 118674505(MMP2)
MLF: 102418715(MMP2)
MNA: 107543503(MMP2)
PKL: 118720617(MMP2)
HAI: 109383663(MMP2)
DRO: 112296673(MMP2)
SHON: 119001111(MMP2)
AJM: 119046441(MMP2)
PDIC: 114488295(MMP2)
PHAS: 123806069(MMP2)
MMF: 118639416(MMP2)
RFQ: 117035241(MMP2)
PALE: 102883808(MMP2)
PGIG: 120617290(MMP2)
PVP: 105292047(MMP2)
RAY: 107499669(MMP2)
MJV: 108387896(MMP2)
TOD: 119248904(MMP2)
SARA: 101540694(MMP2)
LAV: 100659450(MMP2)
TMU: 101358817
DNM: 101442293(MMP2)
MDO: 100020585(MMP2)
GAS: 123235296(MMP2)
SHR: 100935012(MMP2)
PCW: 110207503(MMP2)
OAA: 100077120(MMP2) 103166153
GGA: 386583(MMP2)
PCOC: 116243917(MMP2)
MGP: 100125331(MMP2)
CJO: 107319190(MMP2)
NMEL: 110404299(MMP2)
APLA: 101802059(MMP2)
ACYG: 106043076(MMP2)
AFUL: 116493904(MMP2)
TGU: 100228546(MMP2)
LSR: 110484414(MMP2)
SCAN: 103816631(MMP2)
PMOA: 120508123(MMP2)
OTC: 121333988(MMP2)
PRUF: 121348910(MMP2)
GFR: 102040497(MMP2)
FAB: 101815345(MMP2)
PHI: 102107059(MMP2)
PMAJ: 107209744(MMP2)
CCAE: 111934584(MMP2)
CCW: 104687474(MMP2)
ETL: 114060386(MMP2)
ZAB: 102062240(MMP2)
FPG: 101924896(MMP2)
FCH: 102056005(MMP2)
CLV: 102092170(MMP2)
EGZ: 104125198(MMP2)
NNI: 104016354(MMP2)
ACUN: 113484433(MMP2)
TALA: 104366500(MMP2)
PADL: 103914183(MMP2)
ACHC: 115346374(MMP2)
AAM: 106483196(MMP2)
AROW: 112967552(MMP2)
NPD: 112947679(MMP2)
DNE: 112984295(MMP2)
ASN: 102372370(MMP2)
AMJ: 102562302(MMP2)
CPOO: 109310506(MMP2)
GGN: 109289618(MMP2)
PSS: 102463152(MMP2)
CMY: 102946066(MMP2)
CPIC: 101941088(MMP2)
TST: 117886578(MMP2)
CABI: 116820815(MMP2)
MRV: 120384744(MMP2)
ACS: 100557569(mmp2)
PVT: 110082478(MMP2)
SUND: 121914771(MMP2)
PBI: 103055844(MMP2)
PMUR: 107295718(MMP2)
PGUT: 117670956(MMP2)
VKO: 123022290(MMP2)
PMUA: 114602200(MMP2)
ZVI: 118087109(MMP2)
GJA: 107108344(MMP2)
XLA: 380389(mmp2.S)
XTR: 548506(mmp2)
NPR: 108797889(MMP2)
RTEM: 120917452(MMP2)
BBUF: 120980275(MMP2)
BGAR: 122920492(MMP2)
DRE: 337179(mmp2)
SANH: 107657110(mmp2) 107696695
IPU: 108259638(mmp2)
PHYP: 113540866(mmp2)
SMEO: 124379903(mmp2)
EEE: 113590945(mmp2)
TRU: 653022(mmp2)
LCO: 104926945(mmp2)
NCC: 104964801(mmp2)
CGOB: 115028668(mmp2)
ELY: 117258541(mmp2)
PLEP: 121966899(mmp2)
SLUC: 116037572(mmp2)
ECRA: 117941776(mmp2)
PFLV: 114549991(mmp2)
GAT: 120833716(mmp2)
PPUG: 119197235(mmp2)
MSAM: 119890137(mmp2)
CUD: 121512707(mmp2)
MZE: 101472680(mmp2)
ONL: 100700606(mmp2)
OAU: 116325529(mmp2)
OLA: 100125419(mmp2)
OML: 112160915(mmp2)
XMA: 102226344(mmp2)
XCO: 114142975(mmp2)
XHE: 116718543(mmp2)
PRET: 103462668(mmp2)
PFOR: 103138100(mmp2)
PLAI: 106948460(mmp2)
PMEI: 106910952(mmp2)
GAF: 122840701(mmp2)
CVG: 107095465(mmp2)
CTUL: 119795137(mmp2)
NFU: 107381256(mmp2)
KMR: 108240277(mmp2)
ALIM: 106517245(mmp2)
NWH: 119430131(mmp2)
AOCE: 111577723(mmp2)
CSEM: 103378988(mmp2)
POV: 109625153(mmp2)
SSEN: 122772468(mmp2)
HHIP: 117757506(mmp2)
LCF: 108876984(mmp2)
SDU: 111218486(mmp2)
SLAL: 111649502(mmp2)
XGL: 120801953(mmp2)
HCQ: 109513920(mmp2)
BPEC: 110175240(mmp2)
MALB: 109955873(mmp2)
SASA: 100194903(mmp2) 106562416(MMP2)
OTW: 112263861(mmp2)
ONE: 115121729(mmp2) 115125488
ELS: 105023458(mmp2)
PKI: 111832721(mmp2) 111858175
LOC: 102688130(mmp2)
PSPA: 121296334 121325662(mmp2)
LCM: 102350008(MMP2)
CMK: 103176101(mmp2)
RTP: 109921647(mmp2)
CIN: 100181993
SCLV: 120333349
 » show all
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
J Biol Chem 263:6579-87 (1988)
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
Biochim Biophys Acta 1803:3-19 (2010)
Amalinei C, Caruntu ID, Balan RA
Biology of metalloproteinases.
Rom J Morphol Embryol 48:323-34 (2007)

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