KEGG   PATHWAY: tru03013
Entry
tru03013                    Pathway                                
Name
Nucleocytoplasmic transport - Takifugu rubripes (torafugu)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tru03013  Nucleocytoplasmic transport
tru03013

Other DBs
GO: 0050658
Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
101078454  aaas; aladin [KO:K14320]
101065821  nup42; nucleoporin-like protein 2 [KO:K14321]
101077810  gle1; nucleoporin GLE1 [KO:K18723]
101063764  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
101075257  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
101076600  rae1; mRNA export factor isoform X1 [KO:K14298]
101067065  nup98; nuclear pore complex protein Nup98-Nup96 isoform X2 [KO:K14297]
101071502  nup214; nuclear pore complex protein Nup214 [KO:K14317]
101069527  nup88; nuclear pore complex protein Nup88 [KO:K14318]
101077614  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
101069421  rangap1; ran GTPase-activating protein 1 [KO:K14319]
101061032  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
115248449  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
101077155  ube2i; SUMO-conjugating enzyme UBC9 isoform X2 [KO:K10577]
101072687  SUMO-conjugating enzyme UBC9-like [KO:K10577]
101063780  small ubiquitin-related modifier 3 [KO:K12160]
101072990  sumo2; small ubiquitin-related modifier 2 [KO:K12160]
101073277  small ubiquitin-related modifier 3-like [KO:K12160]
101062618  sumo1; small ubiquitin-related modifier 1 isoform X2 [KO:K12160]
101062320  nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
101072769  nup85; nuclear pore complex protein Nup85 [KO:K14304]
101062656  sec13; protein SEC13 homolog [KO:K14004]
101067952  nup107; nuclear pore complex protein Nup107 [KO:K14301]
101072661  nup133; nuclear pore complex protein Nup133 [KO:K14300]
101064092  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
101079082  nup43; nucleoporin Nup43 isoform X2 [KO:K14305]
101080219  nup37; nucleoporin Nup37 [KO:K14302]
101070297  ahctf1; protein ELYS isoform X2 [KO:K25129]
101067221  nup62; nuclear pore glycoprotein p62 [KO:K14306]
101074861  nup58; nucleoporin p58/p45 isoform X2 [KO:K14307]
101068231  nup54; nucleoporin p54 isoform X1 [KO:K14308]
101076276  nup205; nuclear pore complex protein Nup205 [KO:K14310]
101072772  nup188; nucleoporin NUP188 homolog [KO:K14311]
445935  nup155; nuclear pore complex protein Nup155 [KO:K14312]
101074268  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
101064384  nup35; nucleoporin NUP35 isoform X1 [KO:K14313]
101076535  ndc1; nucleoporin NDC1 [KO:K14315]
101062459  LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
101070139  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
101065683  tmem33; transmembrane protein 33 [KO:K20724]
101065714  tpr; nucleoprotein TPR isoform X1 [KO:K09291]
101077672  nucleoprotein TPR-like [KO:K09291]
101069243  nup50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
101078617  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
101061172  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
101079599  kpna1; importin subunit alpha-5 [KO:K23940]
101070885  kpna2; importin subunit alpha-1 isoform X1 [KO:K15043]
101070461  importin subunit alpha-5-like [KO:K15043]
101065639  kpna3; importin subunit alpha-4 [KO:K23583]
101070362  kpna4; importin subunit alpha-3 isoform X1 [KO:K23583]
101071593  kpna6; importin subunit alpha-7 isoform X1 [KO:K15042]
101061756  kpnb1; importin subunit beta-1 isoform X3 [KO:K14293]
101077251  transportin-1 isoform X1 [KO:K18752]
101073588  transportin-2 [KO:K18727]
101071525  transportin-2 [KO:K18727]
101080098  tnpo3; transportin-3 [KO:K15436]
101067107  ipo4; importin-4 [KO:K20221]
101065423  ipo5; importin-5 [KO:K20222]
101075090  ipo7; importin-7 [KO:K20223]
101067183  ipo8; importin-8 isoform X2 [KO:K18755]
101065604  ipo9; importin-9 isoform X1 [KO:K20224]
101071163  ipo11; importin-11 [KO:K25201]
101076374  importin-13-like [KO:K25202]
101077369  importin-13-like [KO:K25202]
101077787  snupn; snurportin-1 [KO:K13151]
101079764  xpo1; exportin-1 [KO:K14290]
101073809  exportin-1 [KO:K14290]
115249566  exportin-1 [KO:K14290]
101073474  cse1l; exportin-2 [KO:K18423]
101072228  xpo4; exportin-4 [KO:K25203]
101062901  xpo5; exportin-5 [KO:K14289]
101076186  xpo6; exportin-6 [KO:K25204]
101079639  xpo7; exportin-7 isoform X1 [KO:K18460]
101070070  ran; GTP-binding nuclear protein Ran [KO:K07936]
101063194  elongation factor 1-alpha 1 [KO:K03231]
101067847  elongation factor 1-alpha-like [KO:K03231]
101068074  elongation factor 1-alpha [KO:K03231]
101061645  elongation factor 1-alpha-like [KO:K03231]
653026  ef-1a; elongation factor 1 alpha [KO:K03231]
101066465  phax; phosphorylated adapter RNA export protein [KO:K14291]
101077823  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
101062497  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
101070133  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
101065351  rbm8a; RNA-binding protein 8A [KO:K12876]
101074452  protein mago nashi homolog [KO:K12877]
101070509  casc3; protein CASC3 [KO:K14323]
101075694  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
101061384  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
101074005  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
101070895  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
101074911  RNA-binding protein with serine-rich domain 1-B-like isoform X1 [KO:K14325]
101061178  rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
101067411  pnn; pinin [KO:K13114]
101068593  THO complex subunit 4-like isoform X1 [KO:K12881]
101078406  aly/REF export factor 2 [KO:K12881]
101064659  regulator of nonsense transcripts 1-like isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101074742  putative regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101067492  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
101066409  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
101071745  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
101078622  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
101076590  nxt2; NTF2-related export protein 2 [KO:K14285]
101066556  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
101071182  pym1; partner of Y14 and mago [KO:K14294]
101070705  thoc1; THO complex subunit 1 [KO:K12878]
101063594  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
101061978  thoc5; THO complex subunit 5 homolog [KO:K13174]
101067999  thoc6; THO complex subunit 6 homolog [KO:K13175]
101074815  thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
101077375  thoc3; THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tru03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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