KEGG   PATHWAY: tss00270
Entry
tss00270                    Pathway                                
Name
Cysteine and methionine metabolism - Telopea speciosissima (New South Wales waratah)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
tss00270  Cysteine and methionine metabolism
tss00270

Module
tss_M00021  Cysteine biosynthesis, serine => cysteine [PATH:tss00270]
tss_M00034  Methionine salvage pathway [PATH:tss00270]
tss_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:tss00270]
Other DBs
GO: 0006534 0006555
Organism
Telopea speciosissima (New South Wales waratah) [GN:tss]
Gene
122643668  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122643669  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122657907  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
122640223  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122653539  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
122641069  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
122643960  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
122648569  cysteine synthase [KO:K01738] [EC:2.5.1.47]
122648570  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122648572  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
122648573  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
122639993  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
122655758  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
122662430  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like isoform X1 [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122662748  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like isoform X1 [KO:K13034] [EC:2.5.1.47 4.4.1.9]
122644725  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
122643757  selenocysteine methyltransferase-like [KO:K00547] [EC:2.1.1.10]
122639546  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
122664019  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
122671348  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2-like [KO:K00549] [EC:2.1.1.14]
122659855  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
122649760  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like isoform X1 [KO:K00549] [EC:2.1.1.14]
122645767  S-adenosylmethionine synthase 5-like [KO:K00789] [EC:2.5.1.6]
122670963  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
122651408  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
122654282  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
122669121  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
122658377  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122660302  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
122640177  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122665634  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
122659444  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
122672727  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
122664908  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
122654452  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122669296  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122646631  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122660360  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
122660292  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like isoform X1 [KO:K01244] [EC:3.2.2.16]
122661914  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like isoform X1 [KO:K01244] [EC:3.2.2.16]
122660058  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
122657460  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
122648366  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
122652271  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122639939  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
122644126  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122646613  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122642675  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
122655950  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
122651932  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122651933  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122651934  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122651936  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
122640844  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
122671551  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
122651562  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
122639165  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122640215  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122640216  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122640217  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122664562  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
122643858  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
122646492  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
122646680  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
122662817  DNA (cytosine-5)-methyltransferase 1A-like [KO:K00558] [EC:2.1.1.37]
122642230  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
122667714  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
122667910  uncharacterized protein LOC122667910 [KO:K17398] [EC:2.1.1.37]
122657863  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
122667155  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
122646222  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122646404  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122666060  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
122669755  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122659875  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122662309  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
122655644  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
122669381  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
122640436  1-aminocyclopropane-1-carboxylate oxidase isoform X1 [KO:K05933] [EC:1.14.17.4]
122653769  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122642019  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
122668204  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
122672862  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
122656359  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
122661324  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
122652490  aspartate-semialdehyde dehydrogenase-like isoform X1 [KO:K00133] [EC:1.2.1.11]
122671282  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122654147  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
122657101  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122660579  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122661033  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
122667626  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
122672710  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122648973  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122667629  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
122640056  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
122659480  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
122667184  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122670872  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
122671942  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
122649478  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
122639403  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
122651837  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
122652066  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122640850  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
122671287  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
122652694  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
122646432  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
122671528  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
122647796  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122647799  L-cysteine desulfhydrase-like [KO:K22207] [EC:4.4.1.28]
122647800  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
122672570  L-cysteine desulfhydrase-like [KO:K22207] [EC:4.4.1.28]
122659290  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
122663721  malate dehydrogenase-like isoform X1 [KO:K00025] [EC:1.1.1.37]
122642032  malate dehydrogenase 2, cytoplasmic [KO:K00025] [EC:1.1.1.37]
122657580  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
122662027  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
122651838  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
122640805  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
122667545  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
122652568  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic-like [KO:K22846] [EC:2.5.1.144]
122658597  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122660587  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122662181  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
122641767  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
tss00010  Glycolysis / Gluconeogenesis
tss00250  Alanine, aspartate and glutamate metabolism
tss00260  Glycine, serine and threonine metabolism
tss00290  Valine, leucine and isoleucine biosynthesis
tss00430  Taurine and hypotaurine metabolism
tss00480  Glutathione metabolism
tss00620  Pyruvate metabolism
tss00640  Propanoate metabolism
tss00770  Pantothenate and CoA biosynthesis
tss00900  Terpenoid backbone biosynthesis
tss00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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