KEGG   PATHWAY: tvc00260
Entry
tvc00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Tachysurus vachellii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
tvc00260  Glycine, serine and threonine metabolism
tvc00260

Module
tvc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:tvc00260]
tvc_M00047  Creatine pathway [PATH:tvc00260]
tvc_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:tvc00260]
tvc_M00555  Betaine biosynthesis, choline => betaine [PATH:tvc00260]
tvc_M00621  Glycine cleavage system [PATH:tvc00260]
tvc_M00974  Betaine metabolism, animals, betaine => glycine [PATH:tvc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Tachysurus vachellii [GN:tvc]
Gene
132837646  tha1; threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
132844579  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
132864111  serine hydroxymethyltransferase, cytosolic-like isoform X1 [KO:K00600] [EC:2.1.2.1]
132864248  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
132844381  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
132857997  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
132841911  grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
132855600  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
132844670  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
132839092  pgam1b; LOW QUALITY PROTEIN: phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]
132847302  pgam1a; phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
132859785  pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
132856232  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
132850317  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
132854653  psat1; phosphoserine aminotransferase isoform X1 [KO:K00831] [EC:2.6.1.52]
132841489  psph; phosphoserine phosphatase isoform X1 [KO:K01079] [EC:3.1.3.3]
132861419  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
132843343  tdh; L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
132852412  tdh2; L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
132852536  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
132854106  alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
132837900  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
132850152  mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
132863410  si:ch211-127i16.2; probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
132860621  aoc2; LOW QUALITY PROTEIN: retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
132854552  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
132853996  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
132857066  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
132847655  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
132851570  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
132855341  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
132860296  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
132851523  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
132852155  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
132853212  chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
132863281  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
132860088  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
132859925  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
132857856  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132863207  sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
132852183  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
132849738  cystathionine beta-synthase-like isoform X1 [KO:K01697] [EC:4.2.1.22]
132850454  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
132839581  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
132844191  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
132846724  L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]
132854757  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
132852984  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
132850081  zgc:162816; D-serine dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
tvc00010  Glycolysis / Gluconeogenesis
tvc00020  Citrate cycle (TCA cycle)
tvc00230  Purine metabolism
tvc00250  Alanine, aspartate and glutamate metabolism
tvc00270  Cysteine and methionine metabolism
tvc00290  Valine, leucine and isoleucine biosynthesis
tvc00330  Arginine and proline metabolism
tvc00470  D-Amino acid metabolism
tvc00564  Glycerophospholipid metabolism
tvc00600  Sphingolipid metabolism
tvc00620  Pyruvate metabolism
tvc00630  Glyoxylate and dicarboxylate metabolism
tvc00640  Propanoate metabolism
tvc00860  Porphyrin metabolism
tvc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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