KEGG   PATHWAY: twl00270
Entry
twl00270                    Pathway                                
Name
Cysteine and methionine metabolism - Tripterygium wilfordii (thunder duke vine)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
twl00270  Cysteine and methionine metabolism
twl00270

Module
twl_M00021  Cysteine biosynthesis, serine => cysteine [PATH:twl00270]
twl_M00034  Methionine salvage pathway [PATH:twl00270]
twl_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:twl00270]
Other DBs
GO: 0006534 0006555
Organism
Tripterygium wilfordii (thunder duke vine) [GN:twl]
Gene
119988624  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
120012315  serine acetyltransferase 2-like isoform X1 [KO:K00640] [EC:2.3.1.30]
120013856  serine acetyltransferase 2 isoform X1 [KO:K00640] [EC:2.3.1.30]
120004769  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
120006327  serine acetyltransferase 3, mitochondrial-like [KO:K00640] [EC:2.3.1.30]
119996004  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
119985714  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
120012069  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
119989633  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
120014609  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
120014610  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
119981288  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
120009776  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
120009897  cysteine synthase [KO:K01738] [EC:2.5.1.47]
120003285  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
120012452  cystathionine beta-lyase, chloroplastic-like [KO:K01760] [EC:4.4.1.13]
119998353  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
120001644  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
119991353  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
120011028  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
120012878  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
120001794  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like isoform X1 [KO:K00549] [EC:2.1.1.14]
120001795  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
119991325  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
119991340  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
120012711  S-adenosylmethionine synthase 3-like [KO:K00789] [EC:2.5.1.6]
120004060  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
119982403  S-adenosylmethionine synthase 1-like isoform X1 [KO:K00789] [EC:2.5.1.6]
119995455  S-adenosylmethionine synthase 3 isoform X1 [KO:K00789] [EC:2.5.1.6]
119984030  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
119987323  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
120001357  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
120015511  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
119993147  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
119996569  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
119997161  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
119999707  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
119983368  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
120007721  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
119985900  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
119999310  spermidine synthase [KO:K00797] [EC:2.5.1.16]
120013803  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
120006679  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
119996994  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
120008560  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
120010986  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
120002419  5'-methylthioadenosine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
119991715  5'-methylthioadenosine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
120001362  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
119991762  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
119997403  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
119983749  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
119986222  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
120014466  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
119983867  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
119997194  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
120011385  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
120009329  probable N-succinyldiaminopimelate aminotransferase DapC isoform X1 [KO:K23977] [EC:2.6.1.117]
119990119  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
120004586  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
119981760  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
119982006  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
120007904  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
119980500  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
119980296  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
120016172  DNA (cytosine-5)-methyltransferase CMT3-like [KO:K00558] [EC:2.1.1.37]
120006517  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
119984965  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
120000945  uncharacterized protein LOC120000945 [KO:K17398] [EC:2.1.1.37]
120000862  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
119982483  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
119984562  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
119997069  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
119987564  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
119980802  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
120004434  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
119983292  1-aminocyclopropane-1-carboxylate synthase 1-like [KO:K20772] [EC:4.4.1.14]
120013436  1-aminocyclopropane-1-carboxylate synthase-like [KO:K01762] [EC:4.4.1.14]
119995304  1-aminocyclopropane-1-carboxylate synthase-like [KO:K01762] [EC:4.4.1.14]
119997386  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
120009500  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
119988290  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
120016629  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
120005171  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
120005791  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
120008095  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
119999321  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
119980041  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
119997638  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
119992294  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
120010977  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
119994216  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
120016145  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
120011535  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
120011537  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
120011724  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
120008930  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
120009023  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
119998666  branched-chain amino acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
119987172  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
120013516  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119990079  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119986541  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
119981379  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
119986864  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
120009293  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
119992582  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
119992813  aspartate aminotransferase 3, chloroplastic-like [KO:K14454] [EC:2.6.1.1]
120005743  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
119996230  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
120012778  aspartate aminotransferase, mitochondrial-like isoform X1 [KO:K14455] [EC:2.6.1.1]
119981724  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
119993178  aspartate aminotransferase, chloroplastic isoform X1 [KO:K00811] [EC:2.6.1.1]
119997355  aspartate aminotransferase, chloroplastic-like [KO:K00811] [EC:2.6.1.1]
119989224  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
119985730  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
119980522  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
119980605  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
119990784  D-cysteine desulfhydrase 2, mitochondrial [KO:K05396] [EC:4.4.1.15]
119987115  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
119987116  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like isoform X1 [KO:K05396] [EC:4.4.1.15]
119982925  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
120009424  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
120012362  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
120014536  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
119984746  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
120011834  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
119989032  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
119980912  malate dehydrogenase, chloroplastic-like isoform X1 [KO:K00026] [EC:1.1.1.37]
120016968  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
119982237  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
119986259  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
119996290  S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent), chloroplastic isoform X1 [KO:K22846] [EC:2.5.1.144]
120002630  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120014935  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120007329  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120009578  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
120013336  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
120014445  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
twl00010  Glycolysis / Gluconeogenesis
twl00250  Alanine, aspartate and glutamate metabolism
twl00260  Glycine, serine and threonine metabolism
twl00290  Valine, leucine and isoleucine biosynthesis
twl00430  Taurine and hypotaurine metabolism
twl00480  Glutathione metabolism
twl00620  Pyruvate metabolism
twl00640  Propanoate metabolism
twl00770  Pantothenate and CoA biosynthesis
twl00900  Terpenoid backbone biosynthesis
twl00920  Sulfur metabolism
KO pathway
ko00270   
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