KEGG   PATHWAY: vna00260
Entry
vna00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Vibrio natriegens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
vna00260  Glycine, serine and threonine metabolism
vna00260

Module
vna_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:vna00260]
vna_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:vna00260]
vna_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:vna00260]
vna_M00555  Betaine biosynthesis, choline => betaine [PATH:vna00260]
vna_M00621  Glycine cleavage system [PATH:vna00260]
vna_M00919  Ectoine degradation, ectoine => aspartate [PATH:vna00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Vibrio natriegens [GN:vna]
Gene
PN96_05230  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PN96_00270  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PN96_01145  aspartate kinase [KO:K00928] [EC:2.7.2.4]
PN96_11055  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
PN96_14770  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
PN96_02900  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PN96_03170  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PN96_11050  serine kinase [KO:K00872] [EC:2.7.1.39]
PN96_11045  threonine synthase [KO:K01733] [EC:4.2.3.1]
PN96_20210  threonine aldolase [KO:K01620] [EC:4.1.2.48]
PN96_20950  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PN96_22185  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PN96_09955  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PN96_00275  alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PN96_00450  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
PN96_16645  glycerate kinase [KO:K00865] [EC:2.7.1.165]
PN96_01435  glycerate kinase [KO:K00865] [EC:2.7.1.165]
PN96_14435  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
PN96_00930  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PN96_07345  MFS transporter [KO:K00831] [EC:2.6.1.52]
PN96_01765  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PN96_15385  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
PN96_15380  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
PN96_20960  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
PN96_20940  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
PN96_21795  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PN96_01345  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
PN96_20955  glycine cleavage system protein H [KO:K02437]
PN96_00040  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
PN96_19095  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
PN96_19090  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
PN96_22195  Rieske (2Fe-2S) protein [KO:K00479] [EC:1.14.13.251]
PN96_22190  ferredoxin [KO:K21832] [EC:1.14.13.251]
PN96_22360  N-methylproline demethylase [KO:K21833] [EC:1.5.7.3]
PN96_22350  electron transfer flavoprotein subunit alpha [KO:K25960]
PN96_22345  electron transfer flavoprotein subunit beta [KO:K25961]
PN96_22885  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
PN96_22170  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
PN96_22180  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
PN96_22165  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
PN96_22175  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
PN96_04230  serine dehydratase [KO:K01752] [EC:4.3.1.17]
PN96_17145  serine dehydratase [KO:K01752] [EC:4.3.1.17]
PN96_22155  serine dehydratase [KO:K01752] [EC:4.3.1.17]
PN96_13455  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PN96_07340  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
PN96_03905  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
PN96_03910  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PN96_22445  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
PN96_04015  aminotransferase class III [KO:K00836] [EC:2.6.1.76]
PN96_05220  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
PN96_05215  2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
PN96_15825  ectoine synthase [KO:K06720] [EC:4.2.1.108]
PN96_05225  ectoine synthase [KO:K06720] [EC:4.2.1.108]
PN96_17665  X-Pro dipeptidase [KO:K15783] [EC:3.5.4.44]
PN96_17660  deacylase [KO:K15784] [EC:3.5.1.125]
PN96_17645  hypothetical protein [KO:K15785] [EC:2.6.1.76]
PN96_17650  succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
vna00010  Glycolysis / Gluconeogenesis
vna00020  Citrate cycle (TCA cycle)
vna00230  Purine metabolism
vna00250  Alanine, aspartate and glutamate metabolism
vna00270  Cysteine and methionine metabolism
vna00290  Valine, leucine and isoleucine biosynthesis
vna00300  Lysine biosynthesis
vna00330  Arginine and proline metabolism
vna00460  Cyanoamino acid metabolism
vna00470  D-Amino acid metabolism
vna00564  Glycerophospholipid metabolism
vna00600  Sphingolipid metabolism
vna00620  Pyruvate metabolism
vna00630  Glyoxylate and dicarboxylate metabolism
vna00640  Propanoate metabolism
vna00680  Methane metabolism
vna00860  Porphyrin metabolism
vna00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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