KEGG   PATHWAY: vri00270
Entry
vri00270                    Pathway                                
Name
Cysteine and methionine metabolism - Vitis riparia (riverbank grape)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
vri00270  Cysteine and methionine metabolism
vri00270

Module
vri_M00021  Cysteine biosynthesis, serine => cysteine [PATH:vri00270]
vri_M00034  Methionine salvage pathway [PATH:vri00270]
vri_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:vri00270]
Other DBs
GO: 0006534 0006555
Organism
Vitis riparia (riverbank grape) [GN:vri]
Gene
117909369  serine acetyltransferase 1, chloroplastic [KO:K00640] [EC:2.3.1.30]
117912035  probable serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
117924064  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
117925118  serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
117914618  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
117929678  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
117929679  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
117929680  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
117929881  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
117929882  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
117930842  cysteine synthase [KO:K01738] [EC:2.5.1.47]
117908387  cysteine synthase 2-like isoform X1 [KO:K01738] [EC:2.5.1.47]
117908464  cysteine synthase 2-like isoform X1 [KO:K01738] [EC:2.5.1.47]
117912144  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial-like [KO:K13034] [EC:2.5.1.47 4.4.1.9]
117931555  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
117921337  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
117913941  homocysteine S-methyltransferase 3-like [KO:K00547] [EC:2.1.1.10]
117904462  homocysteine S-methyltransferase 2-like [KO:K00547] [EC:2.1.1.10]
117919210  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
117916496  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2 [KO:K00549] [EC:2.1.1.14]
117920343  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
117914379  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
117916851  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
117918531  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
117930128  S-adenosylmethionine synthase 4 [KO:K00789] [EC:2.5.1.6]
117920305  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
117910102  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
117914168  S-adenosylmethionine decarboxylase proenzyme 4 [KO:K01611] [EC:4.1.1.50]
117917657  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
117921792  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
117933978  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
117905087  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
117924928  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
117929515  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
117911481  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2-like isoform X1 [KO:K01244] [EC:3.2.2.16]
117908484  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
117908492  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
117925663  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
117904773  methylthioribose-1-phosphate isomerase-like [KO:K08963] [EC:5.3.1.23]
117910663  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 2 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
117927369  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 2 isoform X1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
117908754  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
117913816  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
117914781  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
117915069  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
117907608  LOW QUALITY PROTEIN: probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
117909455  probable aminotransferase TAT2 isoform X1 [KO:K00815] [EC:2.6.1.5]
117927179  nicotianamine aminotransferase 1-like [KO:K00815] [EC:2.6.1.5]
117927375  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
117927376  tyrosine aminotransferase-like [KO:K00815] [EC:2.6.1.5]
117927377  tyrosine aminotransferase-like isoform X1 [KO:K00815] [EC:2.6.1.5]
117922184  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
117912807  aromatic aminotransferase ISS1-like [KO:K00837] [EC:2.6.1.-]
117933763  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
117934131  DNA (cytosine-5)-methyltransferase CMT2-like isoform X1 [KO:K00558] [EC:2.1.1.37]
117926622  DNA (cytosine-5)-methyltransferase 1B-like [KO:K00558] [EC:2.1.1.37]
117916232  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
117928736  DNA (cytosine-5)-methyltransferase CMT2-like [KO:K00558] [EC:2.1.1.37]
117917548  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
117918489  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
117919713  putative DNA (cytosine-5)-methyltransferase CMT1 [KO:K00558] [EC:2.1.1.37]
117930130  uncharacterized protein LOC117930130 [KO:K17398] [EC:2.1.1.37]
117914521  adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
117904674  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
117904691  adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
117931832  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
117932327  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
117925499  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
117915440  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
117907340  1-aminocyclopropane-1-carboxylate synthase 3 [KO:K01762] [EC:4.4.1.14]
117919034  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
117923450  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
117925646  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
117927303  1-aminocyclopropane-1-carboxylate oxidase 3 [KO:K05933] [EC:1.14.17.4]
117906345  1-aminocyclopropane-1-carboxylate oxidase 5 [KO:K05933] [EC:1.14.17.4]
117930862  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
117919964  aspartokinase 1, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
117906853  LOW QUALITY PROTEIN: bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
117907174  LOW QUALITY PROTEIN: bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
117924137  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
117931395  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
117931396  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
117907405  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
117918734  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
117907781  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
117916925  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
117919030  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
117919662  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
117904044  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
117931014  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
117913190  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
117925418  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
117905881  aspartate aminotransferase, cytoplasmic-like [KO:K14454] [EC:2.6.1.1]
117925803  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
117919691  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
117913594  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
117909424  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial [KO:K01011] [EC:2.8.1.1 2.8.1.2]
117926640  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
117932737  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
117924011  D-cysteine desulfhydrase 2, mitochondrial isoform X1 [KO:K05396] [EC:4.4.1.15]
117904156  bifunctional D-cysteine desulfhydrase/1-aminocyclopropane-1-carboxylate deaminase, mitochondrial-like [KO:K05396] [EC:4.4.1.15]
117904746  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
117930146  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
117919398  L-cysteine desulfhydrase [KO:K22207] [EC:4.4.1.28]
117917722  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
117917723  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
117931734  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
117931745  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
117909644  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
117911303  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
117923908  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
117904394  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
117918935  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
117930858  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
117919679  cysteine synthase [KO:K22846] [EC:2.5.1.144]
117911364  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
117922268  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
117906119  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
117913155  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
vri00010  Glycolysis / Gluconeogenesis
vri00250  Alanine, aspartate and glutamate metabolism
vri00260  Glycine, serine and threonine metabolism
vri00290  Valine, leucine and isoleucine biosynthesis
vri00430  Taurine and hypotaurine metabolism
vri00480  Glutathione metabolism
vri00620  Pyruvate metabolism
vri00640  Propanoate metabolism
vri00770  Pantothenate and CoA biosynthesis
vri00900  Terpenoid backbone biosynthesis
vri00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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