KEGG   PATHWAY: vum00270
Entry
vum00270                    Pathway                                
Name
Cysteine and methionine metabolism - Vigna umbellata (ricebean)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
vum00270  Cysteine and methionine metabolism
vum00270

Module
vum_M00021  Cysteine biosynthesis, serine => cysteine [PATH:vum00270]
vum_M00034  Methionine salvage pathway [PATH:vum00270]
vum_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:vum00270]
Other DBs
GO: 0006534 0006555
Organism
Vigna umbellata (ricebean) [GN:vum]
Gene
124821425  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
124835207  serine acetyltransferase 1, chloroplastic-like isoform X1 [KO:K00640] [EC:2.3.1.30]
124835310  serine acetyltransferase 2-like [KO:K00640] [EC:2.3.1.30]
124839781  serine acetyltransferase 5-like [KO:K00640] [EC:2.3.1.30]
124831789  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
124831791  serine acetyltransferase 1, chloroplastic-like [KO:K00640] [EC:2.3.1.30]
124820421  putative inactive cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
124844490  cysteine synthase 2 [KO:K01738] [EC:2.5.1.47]
124821101  cysteine synthase-like isoform X1 [KO:K01738] [EC:2.5.1.47]
124824772  cysteine synthase [KO:K01738] [EC:2.5.1.47]
124838353  bifunctional L-3-cyanoalanine synthase/cysteine synthase D1-like isoform X1 [KO:K01738] [EC:2.5.1.47]
124841708  cysteine synthase [KO:K01738] [EC:2.5.1.47]
124827367  bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial [KO:K13034] [EC:2.5.1.47 4.4.1.9]
124825118  cystathionine beta-lyase, chloroplastic [KO:K01760] [EC:4.4.1.13]
124823901  selenocysteine methyltransferase-like [KO:K00547] [EC:2.1.1.10]
124836411  homocysteine S-methyltransferase 3-like isoform X1 [KO:K00547] [EC:2.1.1.10]
124834855  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]
124847730  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase-like [KO:K00549] [EC:2.1.1.14]
124824315  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1-like [KO:K00549] [EC:2.1.1.14]
124821483  S-adenosylmethionine synthase 1-like [KO:K00789] [EC:2.5.1.6]
124836604  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
124825062  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
124838241  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
124838244  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
124838269  S-adenosylmethionine synthase-like [KO:K00789] [EC:2.5.1.6]
124827355  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
124846192  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
124847566  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
124826487  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
124827173  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
124839474  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
124840340  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
124829660  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
124841734  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
124842260  LOW QUALITY PROTEIN: spermine synthase-like [KO:K00797] [EC:2.5.1.16]
124846082  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
124838978  nicotianamine synthase [KO:K05953] [EC:2.5.1.43]
124829350  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
124837300  5'-methylthioadenosine nucleosidase-like isoform X1 [KO:K01244] [EC:3.2.2.16]
124837308  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase-like [KO:K01244] [EC:3.2.2.16]
124832151  methylthioribose kinase [KO:K00899] [EC:2.7.1.100]
124843432  methylthioribose kinase-like [KO:K00899] [EC:2.7.1.100]
124829342  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
124832956  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
124836238  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2-like [KO:K08967] [EC:1.13.11.53 1.13.11.54]
124836291  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
124832121  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
124822974  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
124832073  nicotianamine aminotransferase 1-like isoform X1 [KO:K00815] [EC:2.6.1.5]
124828574  aromatic aminotransferase ISS1 [KO:K00837] [EC:2.6.1.-]
124832290  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
124842672  methionine gamma-lyase-like [KO:K01761] [EC:4.4.1.11]
124844377  DNA (cytosine-5)-methyltransferase CMT2 isoform X1 [KO:K00558] [EC:2.1.1.37]
124835311  putative DNA (cytosine-5)-methyltransferase CMT1 [KO:K00558] [EC:2.1.1.37]
124836060  DNA (cytosine-5)-methyltransferase CMT3 [KO:K00558] [EC:2.1.1.37]
124836718  DNA (cytosine-5)-methyltransferase 1-like [KO:K00558] [EC:2.1.1.37]
124826211  PWWP domain-containing protein 1-like isoform X1 [KO:K17398] [EC:2.1.1.37]
124820582  LOW QUALITY PROTEIN: adenosylhomocysteinase-like [KO:K01251] [EC:3.13.2.1]
124845029  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
124833932  1-aminocyclopropane-1-carboxylate synthase-like [KO:K20772] [EC:4.4.1.14]
124827298  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
124846096  1-aminocyclopropane-1-carboxylate synthase CMA101-like [KO:K01762] [EC:4.4.1.14]
124821753  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
124823211  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
124848487  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
124827856  1-aminocyclopropane-1-carboxylate synthase 3-like [KO:K01762] [EC:4.4.1.14]
124832977  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
124833703  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
124845908  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
124823267  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
124841262  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
124841263  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
124830862  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
124830864  1-aminocyclopropane-1-carboxylate oxidase 5-like [KO:K05933] [EC:1.14.17.4]
124832008  1-aminocyclopropane-1-carboxylate oxidase-like [KO:K05933] [EC:1.14.17.4]
124841104  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
124823890  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
124839709  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
124832055  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
124822302  LOW QUALITY PROTEIN: aspartate-semialdehyde dehydrogenase-like [KO:K00133] [EC:1.2.1.11]
124828362  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
124822167  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
124822178  branched-chain amino acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
124830352  putative branched-chain-amino-acid aminotransferase 7 [KO:K00826] [EC:2.6.1.42]
124830353  branched-chain-amino-acid aminotransferase 2, chloroplastic-like isoform X1 [KO:K00826] [EC:2.6.1.42]
124830355  putative branched-chain-amino-acid aminotransferase 7 [KO:K00826] [EC:2.6.1.42]
124830357  branched-chain amino acid aminotransferase 1, mitochondrial-like isoform X1 [KO:K00826] [EC:2.6.1.42]
124843468  branched-chain-amino-acid aminotransferase 2, chloroplastic-like [KO:K00826] [EC:2.6.1.42]
124841619  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
124831983  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
124835154  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
124835161  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
124824130  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
124824151  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
124824152  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
124820643  aspartate aminotransferase 1 [KO:K14454] [EC:2.6.1.1]
124844149  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
124831969  aspartate aminotransferase, mitochondrial-like [KO:K14455] [EC:2.6.1.1]
124825265  aspartate aminotransferase P2, mitochondrial [KO:K00811] [EC:2.6.1.1]
124841110  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial-like [KO:K01011] [EC:2.8.1.1 2.8.1.2]
124822124  L-lactate dehydrogenase A-like [KO:K00016] [EC:1.1.1.27]
124847659  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
124819515  L-lactate dehydrogenase B-like [KO:K00016] [EC:1.1.1.27]
124843980  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
124847625  D-cysteine desulfhydrase 2, mitochondrial [KO:K05396] [EC:4.4.1.15]
124845597  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
124824959  probable L-cysteine desulfhydrase, chloroplastic [KO:K22207] [EC:4.4.1.28]
124840448  L-cysteine desulfhydrase-like [KO:K22207] [EC:4.4.1.28]
124840450  L-cysteine desulfhydrase-like [KO:K22207] [EC:4.4.1.28]
124843944  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
124842792  malate dehydrogenase, cytoplasmic-like isoform X1 [KO:K00025] [EC:1.1.1.37]
124824694  LOW QUALITY PROTEIN: malate dehydrogenase 2, peroxisomal-like [KO:K00026] [EC:1.1.1.37]
124826986  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
124830779  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
124825743  uncharacterized protein LOC124825743 [KO:K22846] [EC:2.5.1.144]
124832150  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
124831684  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
124821422  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
124843593  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
124843596  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
PMID:15102328
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
PMID:14551435
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
PMID:12022921
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
PMID:12670965
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
PMID:17169919
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
PMID:17030798
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
PMID:18625006
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
PMID:18391471
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
PMID:10613873
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
PMID:12644499
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
PMID:18520135
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19270684
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
vum00010  Glycolysis / Gluconeogenesis
vum00250  Alanine, aspartate and glutamate metabolism
vum00260  Glycine, serine and threonine metabolism
vum00290  Valine, leucine and isoleucine biosynthesis
vum00430  Taurine and hypotaurine metabolism
vum00480  Glutathione metabolism
vum00620  Pyruvate metabolism
vum00640  Propanoate metabolism
vum00770  Pantothenate and CoA biosynthesis
vum00900  Terpenoid backbone biosynthesis
vum00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

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