KEGG   PATHWAY: xgl03083
Entry
xgl03083                    Pathway                                
Name
Polycomb repressive complex - Xiphias gladius (swordfish)
Class
Genetic Information Processing; Chromosome
Pathway map
xgl03083  Polycomb repressive complex
xgl03083

Organism
Xiphias gladius (swordfish) [GN:xgl]
Gene
120785995  ezh1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
120789563  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
120798334  eed; polycomb protein eed [KO:K11462]
120785910  polycomb protein suz12-B-like [KO:K11463]
120799733  suz12b; polycomb protein suz12-B [KO:K11463]
120786522  rbbp4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
120788386  histone-binding protein RBBP7 [KO:K10752]
120795035  histone-binding protein RBBP4 [KO:K10752]
120784638  phf1; PHD finger protein 1 isoform X1 [KO:K11467]
120799295  mtf2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
120787515  phf19; PHD finger protein 19 [KO:K11486]
120800733  lcor; ligand-dependent corepressor [KO:K26260]
120803023  aebp2; zinc finger protein AEBP2 [KO:K17452]
120793298  zinc finger protein aebp2-like isoform X1 [KO:K17452]
120786929  jarid2b; protein Jumonji isoform X1 [KO:K11478]
120807151  bap1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
120803760  asxl1; putative Polycomb group protein ASXL1 [KO:K11471]
120795234  asxl2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
120785102  ogt.1; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
120804067  hcfc1b; host cell factor 1b isoform X1 [KO:K14966]
120783327  hcfc1a; host cell factor 1a isoform X1 [KO:K14966]
120789400  yy1b; transcriptional repressor protein YY1b isoform X1 [KO:K09201]
120795312  yy1a; transcriptional repressor protein YY1a [KO:K09201]
120798286  methyl-CpG-binding domain protein 5-like [KO:K23219]
120803827  proline-rich protein 36-like [KO:K26585]
120794576  forkhead box protein K2-like [KO:K09404]
120800887  foxk1; forkhead box protein K1 isoform X1 [KO:K09404]
120806729  foxk2b; forkhead box protein K2 [KO:K09404]
120798703  rnf2; E3 ubiquitin-protein ligase RING2 isoform X1 [KO:K10695] [EC:2.3.2.27]
120786474  E3 ubiquitin-protein ligase RING2-A-like [KO:K10695] [EC:2.3.2.27]
120800417  polycomb group RING finger protein 2-like [KO:K11460]
120789836  bmi1a; polycomb complex protein BMI-1-A [KO:K11459]
120788487  cbx2; chromobox protein homolog 2 [KO:K11451]
120794587  LOW QUALITY PROTEIN: chromobox protein homolog 2-like [KO:K11451]
120784604  cbx4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
120800275  E3 SUMO-protein ligase CBX4-like [KO:K11452] [EC:2.3.2.-]
120788257  cbx7a; chromobox homolog 7a isoform X1 [KO:K11454]
120794831  cbx7b; chromobox protein homolog 7 [KO:K11454]
120784609  cbx8a; chromobox protein homolog 8a [KO:K11455]
120799608  cbx8b; chromobox protein homolog 8b [KO:K11455]
120786677  LOW QUALITY PROTEIN: polyhomeotic-like protein 1 [KO:K11456]
120784063  phc1; polyhomeotic-like protein 1 [KO:K11456]
120783305  phc2b; polyhomeotic-like protein 2b [KO:K11457]
120804341  phc2a; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
120799126  phc3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
120790029  si:ch211-230g15.5; LOW QUALITY PROTEIN: polyhomeotic-like protein 3 [KO:K11458]
120791379  sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
120788079  scml2; polycomb protein SCMH1 [KO:K11465]
120783981  polycomb protein SCMH1 isoform X1 [KO:K11461]
120801403  sfmbt2; scm-like with four MBT domains protein 2 [KO:K26269]
120783299  sfmbt1; scm-like with four MBT domains protein 1 isoform X1 [KO:K26269]
120785344  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
120796793  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
120785197  ubiquitin-conjugating enzyme E2 2-like [KO:K06689] [EC:2.3.2.23]
120785240  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
120805302  ube2d4; ubiquitin-conjugating enzyme E2 D4 isoform X1 [KO:K06689] [EC:2.3.2.23]
120794409  ube2d1b; ubiquitin-conjugating enzyme E2 D1b isoform X1 [KO:K06689] [EC:2.3.2.23]
120795366  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
120784828  usp45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
120791669  usp16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
120807527  rybpb; RING1 and YY1-binding protein B [KO:K11469]
120793004  YY1-associated factor 2-like isoform X1 [KO:K11468]
120801451  yaf2; YY1-associated factor 2 [KO:K11468]
120784958  pcgf1; polycomb group RING finger protein 1 isoform X1 [KO:K11487]
120785238  kdm2ab; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
120805096  kdm2ba; lysine (K)-specific demethylase 2Ba isoform X1 [KO:K10276] [EC:1.14.11.27]
120799999  kdm2aa; lysine (K)-specific demethylase 2Aa isoform X1 [KO:K10276] [EC:1.14.11.27]
120805980  lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
120798355  BCL-6 corepressor-like [KO:K23215]
120801328  bcor; BCL-6 corepressor isoform X1 [KO:K23215]
120785296  bcorl1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
120803142  skp1; S-phase kinase-associated protein 1 [KO:K03094]
120783228  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
120785461  polycomb group RING finger protein 3 isoform X1 [KO:K11488]
120796660  pcgf5b; polycomb group RING finger protein 5-B [KO:K11489]
120786761  csnk2b; casein kinase II subunit beta [KO:K03115]
120783906  casein kinase II subunit beta [KO:K03115]
120802719  auts2a; autism susceptibility gene 2 protein [KO:K23214]
120794203  fbrs; autism susceptibility gene 2 protein homolog isoform X1 [KO:K26253]
120805118  fbrsl1; autism susceptibility gene 2 protein isoform X1 [KO:K26254]
120785463  dcaf7; DDB1- and CUL4-associated factor 7 [KO:K11805]
120784314  tex10; testis-expressed protein 10 homolog [KO:K14827]
120799899  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
120788269  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
120794208  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
120783384  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
120796103  pcgf6; polycomb group RING finger protein 6 [KO:K11470]
120788570  transcription factor E2F3-like [KO:K09390]
120789298  e2f6; transcription factor E2F6 isoform X1 [KO:K09390]
120801765  transcription factor Dp-1-like [KO:K04683]
120789036  max; protein max isoform X1 [KO:K04453]
120795423  protein max-like isoform X1 [KO:K04453]
120788760  magl; MAX gene-associated protein isoform X1 [KO:K23399]
120795064  mgaa; MAX dimerization protein MGA a isoform X1 [KO:K23399]
120784427  l3mbtl1b; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
120804353  l3mbtl1; lethal(3)malignant brain tumor-like protein 1 [KO:K24387]
120794209  l3mbtl2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
120789935  lethal(3)malignant brain tumor-like protein 4 [KO:K24387]
120785915  cbx3a; chromobox protein homolog 3a isoform X1 [KO:K11586]
120783560  cbx3b; chromobox protein homolog 3b [KO:K11586]
120787495  WD repeat-containing protein 5-like [KO:K14963]
120806871  wdr5; WD repeat-containing protein 5 [KO:K14963]
120786688  hdac1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
120789162  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120795513  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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