KEGG   PATHWAY: zca03083
Entry
zca03083                    Pathway                                
Name
Polycomb repressive complex - Zalophus californianus (California sea lion)
Class
Genetic Information Processing; Chromosome
Pathway map
zca03083  Polycomb repressive complex
zca03083

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113939411  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
113911424  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
113914502  EED; polycomb protein EED isoform X1 [KO:K11462]
113907918  SUZ12; polycomb protein SUZ12 isoform X1 [KO:K11463]
113929150  histone-binding protein RBBP4 [KO:K10752]
113907842  RBBP4; histone-binding protein RBBP4 isoform X1 [KO:K10752]
118357364  histone-binding protein RBBP4-like [KO:K10752]
113921965  LOW QUALITY PROTEIN: histone-binding protein RBBP4-like [KO:K10752]
113930411  LOW QUALITY PROTEIN: histone-binding protein RBBP4-like [KO:K10752]
113930328  RBBP7; histone-binding protein RBBP7 isoform X1 [KO:K11659]
113932997  LOW QUALITY PROTEIN: histone-binding protein RBBP7-like [KO:K11659]
113926348  PHF1; PHD finger protein 1 isoform X1 [KO:K11467]
113933540  MTF2; metal-response element-binding transcription factor 2 isoform X1 [KO:K11485]
113934170  PHF19; PHD finger protein 19 isoform X1 [KO:K11486]
113939202  elongin BC and Polycomb repressive complex 2-associated protein [KO:K26259]
113918751  LCOR; ligand-dependent corepressor isoform X1 [KO:K26260]
113921872  AEBP2; zinc finger protein AEBP2 [KO:K17452]
113926594  JARID2; protein Jumonji isoform X3 [KO:K11478]
113921958  LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase BAP1-like [KO:K08588] [EC:3.4.19.12]
113918460  BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [KO:K08588] [EC:3.4.19.12]
113936926  ASXL1; polycomb group protein ASXL1 isoform X1 [KO:K11471]
113912269  ASXL3; putative Polycomb group protein ASXL3 isoform X1 [KO:K11471]
113937536  ASXL2; putative Polycomb group protein ASXL2 isoform X1 [KO:K11471]
113930291  OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667] [EC:2.4.1.255]
113930667  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
113910410  YY1; transcriptional repressor protein YY1 [KO:K09201]
113919392  MBD5; methyl-CpG-binding domain protein 5 [KO:K23219]
113922872  MBD6; methyl-CpG-binding domain protein 6 isoform X1 [KO:K26585]
113931764  FOXK1; forkhead box protein K1 [KO:K09404]
118355934  forkhead box protein K2-like [KO:K09404]
113939208  FOXK2; forkhead box protein K2 [KO:K09404]
113932405  RNF2; E3 ubiquitin-protein ligase RING2 isoform X1 [KO:K10695] [EC:2.3.2.27]
113926432  RING1; E3 ubiquitin-protein ligase RING1 [KO:K10695] [EC:2.3.2.27]
113939514  PCGF2; polycomb group RING finger protein 2 isoform X3 [KO:K11460]
113921888  BMI1; polycomb complex protein BMI-1 [KO:K11459]
113914322  polycomb complex protein BMI-1-like [KO:K11459]
113938952  CBX2; chromobox protein homolog 2 [KO:K11451]
113908070  CBX4; E3 SUMO-protein ligase CBX4 [KO:K11452] [EC:2.3.2.-]
113921676  CBX6; chromobox protein homolog 6 isoform X1 [KO:K11453]
113921549  CBX7; chromobox protein homolog 7 isoform X1 [KO:K11454]
113908071  CBX8; chromobox protein homolog 8 [KO:K11455]
113921818  PHC1; polyhomeotic-like protein 1 isoform X1 [KO:K11456]
113928054  PHC2; polyhomeotic-like protein 2 isoform X1 [KO:K11457]
113916663  PHC3; polyhomeotic-like protein 3 isoform X1 [KO:K11458]
113930973  SCML1; sex comb on midleg-like protein 1 isoform X1 [KO:K11464]
113931309  SCML2; sex comb on midleg-like protein 2 isoform X1 [KO:K11465]
113925006  SCMH1; LOW QUALITY PROTEIN: polycomb protein SCMH1 [KO:K11461]
113922757  SFMBT2; scm-like with four MBT domains protein 2 isoform X1 [KO:K26269]
113917031  SFMBT1; LOW QUALITY PROTEIN: scm-like with four MBT domains protein 1 [KO:K26269]
113939703  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
113924587  UBE2D3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
113928935  UBE2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
113922229  UBE2D1; ubiquitin-conjugating enzyme E2 D1 isoform X1 [KO:K06689] [EC:2.3.2.23]
113927191  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113917437  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113922522  ubiquitin-conjugating enzyme E2 D3-like [KO:K06689] [EC:2.3.2.23]
113927338  USP45; ubiquitin carboxyl-terminal hydrolase 45 isoform X1 [KO:K11844] [EC:3.4.19.12]
113917126  USP16; ubiquitin carboxyl-terminal hydrolase 16 isoform X1 [KO:K11844] [EC:3.4.19.12]
113917920  RING1 and YY1-binding protein [KO:K11469]
113922524  YAF2; YY1-associated factor 2 isoform X1 [KO:K11468]
113938263  PCGF1; polycomb group RING finger protein 1 isoform X1 [KO:K11487]
113913959  KDM2A; lysine-specific demethylase 2A isoform X1 [KO:K10276] [EC:1.14.11.27]
113912625  KDM2B; lysine-specific demethylase 2B isoform X1 [KO:K10276] [EC:1.14.11.27]
113930741  BCOR; BCL-6 corepressor isoform X1 [KO:K23215]
118356653  LOW QUALITY PROTEIN: BCL-6 corepressor-like [KO:K23215]
113931445  BCORL1; BCL-6 corepressor-like protein 1 isoform X1 [KO:K26199]
113928408  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
113917386  S-phase kinase-associated protein 1 [KO:K03094]
113925388  S-phase kinase-associated protein 1-like [KO:K03094]
113937446  S-phase kinase-associated protein 1-like [KO:K03094]
113938072  S-phase kinase-associated protein 1-like [KO:K03094]
113932039  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
113924377  PCGF3; polycomb group RING finger protein 3 [KO:K11488]
113923628  PCGF5; polycomb group RING finger protein 5 isoform X1 [KO:K11489]
113927749  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
113925460  casein kinase II subunit beta-like [KO:K03115]
113927342  casein kinase II subunit beta-like [KO:K03115]
113932824  casein kinase II subunit beta-like [KO:K03115]
113931844  AUTS2; autism susceptibility gene 2 protein isoform X1 [KO:K23214]
113932100  LOW QUALITY PROTEIN: autism susceptibility gene 2 protein-like [KO:K23214]
113933061  FBRS; probable fibrosin-1 isoform X1 [KO:K26253]
113912680  FBRSL1; fibrosin-1-like protein isoform X1 [KO:K26254]
113939462  DCAF7; DDB1- and CUL4-associated factor 7 [KO:K11805]
113934350  TEX10; testis-expressed protein 10 isoform X1 [KO:K14827]
113913624  testis-expressed protein 10-like [KO:K14827]
113921697  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113931903  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
113923804  PCGF6; polycomb group RING finger protein 6 isoform X1 [KO:K11470]
113938122  E2F6; transcription factor E2F6 isoform X1 [KO:K09390]
113920682  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
113909959  MAX; protein max isoform X1 [KO:K04453]
113928522  LOW QUALITY PROTEIN: protein max-like [KO:K04453]
113908819  MGA; MAX gene-associated protein isoform X1 [KO:K23399]
113913134  L3MBTL4; lethal(3)malignant brain tumor-like protein 4 isoform X1 [KO:K24387]
113927617  L3MBTL3; lethal(3)malignant brain tumor-like protein 3 isoform X1 [KO:K24387]
113922495  L3MBTL2; lethal(3)malignant brain tumor-like protein 2 isoform X1 [KO:K24387]
113938057  L3MBTL1; lethal(3)malignant brain tumor-like protein 1 isoform X1 [KO:K24387]
113916891  chromobox protein homolog 3-like [KO:K11586]
113911266  CBX3; chromobox protein homolog 3 [KO:K11586]
113930668  chromobox protein homolog 3-like [KO:K11586]
118357346  chromobox protein homolog 3 [KO:K11586]
113915691  chromobox protein homolog 3-like [KO:K11586]
113934054  chromobox protein homolog 3-like [KO:K11586]
113934938  chromobox protein homolog 3-like [KO:K11586]
113912868  chromobox protein homolog 3-like [KO:K11586]
113934945  WDR5; WD repeat-containing protein 5 [KO:K14963]
113918957  WDR5B; WD repeat-containing protein 5B [KO:K14963]
113932692  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
113927248  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
113930489  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
Reference
PMID:21881606
  Authors
Richly H, Aloia L, Di Croce L
  Title
Roles of the Polycomb group proteins in stem cells and cancer.
  Journal
Cell Death Dis 2:e204 (2011)
DOI:10.1038/cddis.2011.84
Reference
PMID:28202673
  Authors
Chittock EC, Latwiel S, Miller TC, Muller CW
  Title
Molecular architecture of polycomb repressive complexes.
  Journal
Biochem Soc Trans 45:193-205 (2017)
DOI:10.1042/BST20160173
Reference
PMID:33202645
  Authors
Geng Z, Gao Z
  Title
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms.
  Journal
Int J Mol Sci 21:ijms21228594 (2020)
DOI:10.3390/ijms21228594
Reference
PMID:35681061
  Authors
Kim JJ, Kingston RE
  Title
Context-specific Polycomb mechanisms in development.
  Journal
Nat Rev Genet 23:680-695 (2022)
DOI:10.1038/s41576-022-00499-0
Reference
PMID:36076977
  Authors
Dong GJ, Xu JL, Qi YR, Yuan ZQ, Zhao W
  Title
Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer.
  Journal
Int J Mol Sci 23:ijms23179574 (2022)
DOI:10.3390/ijms23179574
Reference
PMID:37086328
  Authors
Ryan CW, Peirent ER, Regan SL, Guxholli A, Bielas SL
  Title
H2A monoubiquitination: insights from human genetics and animal models.
  Journal
Hum Genet 10.1007/s00439-023-02557-x (2023)
DOI:10.1007/s00439-023-02557-x
KO pathway
ko03083   
LinkDB

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