KEGG   PATHWAY: pcoq04137
Entry
pcoq04137                   Pathway                                
Name
Mitophagy - animal - Propithecus coquereli (Coquerel's sifaka)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
pcoq04137  Mitophagy - animal
pcoq04137

Other DBs
GO: 0000422
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804919  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105804948  E2F1; transcription factor E2F1 [KO:K17454]
105804954  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105805035  PHB2; prohibitin-2 [KO:K17081]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105806029  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
105806036  CCZ1; vacuolar fusion protein CCZ1 homolog [KO:K27045]
105806239  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105806450  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
105807075  RABGEF1; rab5 GDP/GTP exchange factor isoform X1 [KO:K20131]
105807290  ARIH1; E3 ubiquitin-protein ligase ARIH1 [KO:K11968] [EC:2.3.2.31]
105807350  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
105807436  TFEB; transcription factor EB [KO:K15590]
105807545  KRAS; GTPase KRas [KO:K07827]
105807995  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
105808016  MON1B; vacuolar fusion protein MON1 homolog B isoform X1 [KO:K20195]
105808382  TBC1D15; TBC1 domain family member 15 [KO:K20168]
105808416  OPA1; dynamin-like 120 kDa protein, mitochondrial [KO:K17079] [EC:3.6.5.5]
105808786  ATG9A; autophagy-related protein 9A [KO:K17907]
105809045  FUNDC1; FUN14 domain-containing protein 1 [KO:K17986]
105809366  TBC1D17; TBC1 domain family member 17 [KO:K19945]
105809401  RRAS; ras-related protein R-Ras [KO:K07829]
105810299  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105810391  [KO:K10435]
105810591  NRAS; GTPase NRas [KO:K07828]
105811088  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105812371  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105813220  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
105813583  RHOT1; mitochondrial Rho GTPase 1 isoform X1 [KO:K07870] [EC:3.6.5.-]
105814259  USP8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
105814728  [KO:K04570]
105814769  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105815092  USP30; ubiquitin carboxyl-terminal hydrolase 30 [KO:K11851] [EC:3.4.19.12]
105815340  CITED2; cbp/p300-interacting transactivator 2 [KO:K21361]
105815466  [KO:K20168]
105815521  MTX2; metaxin-2 [KO:K17776]
105815789  BCL2L13; bcl-2-like protein 13 [KO:K15485]
105815896  [KO:K03237]
105815931  FOXO3; forkhead box protein O3 [KO:K09408]
105815999  [KO:K04440] [EC:2.7.11.24]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816656  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105816779  TFE3; transcription factor E3 [KO:K09105]
105817175  TOMM70A; mitochondrial import receptor subunit TOM70 [KO:K17768]
105817645  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
105817842  RAB5B; ras-related protein Rab-5B [KO:K07888]
105817894  CSNK2B; casein kinase II subunit beta [KO:K03115]
105818043  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
105818097  [KO:K02927]
105818138  FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8 [KO:K09574] [EC:5.2.1.8]
105818146  [KO:K02927]
105818410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105818878  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
105819239  NLRX1; NLR family member X1 [KO:K12653]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105819431  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105819508  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
105819700  RAB7A; ras-related protein Rab-7a [KO:K07897]
105819837  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
105819858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105819976  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
105820204  NBR1; next to BRCA1 gene 1 protein [KO:K17987]
105820245  BECN1; beclin-1 isoform X1 [KO:K08334]
105820246  RAB5C; ras-related protein Rab-5C [KO:K07889]
105820722  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
105820727  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105820873  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
105821039  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105821193  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
105821407  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
105821901  MTX1; metaxin-1 isoform X1 [KO:K17776]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105822308  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
105822310  MUL1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
105822532  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
105822597  RHOT2; mitochondrial Rho GTPase 2 isoform X1 [KO:K07871] [EC:3.6.5.-]
105822701  MARCH5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
105822961  MON1A; vacuolar fusion protein MON1 homolog A [KO:K20195]
105823202  TOMM20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
105823270  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105823436  HUWE1; E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823688  OPTN; optineurin isoform X1 [KO:K19946]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105824198  USP15; ubiquitin carboxyl-terminal hydrolase 15 isoform X1 [KO:K21343] [EC:3.4.19.12]
105824575  ATG9B; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907]
105824927  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
105824956  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
105825257  BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
105825561  UBC; polyubiquitin-C [KO:K02927]
105825908  TOMM20L; TOMM20-like protein 1 [KO:K17770]
105826041  FIS1; mitochondrial fission 1 protein [KO:K17969]
105826282  SAMM50; sorting and assembly machinery component 50 homolog isoform X1 [KO:K07277]
105826386  RAB5A; ras-related protein Rab-5A [KO:K07887]
105826493  MTX3; metaxin-3 [KO:K17776]
105826598  MRAS; ras-related protein M-Ras [KO:K07831]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
pcoq04140  Autophagy - animal
pcoq04210  Apoptosis
KO pathway
ko04137   

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