KEGG   PATHWAY: pcoq04140
Entry
pcoq04140                   Pathway                                
Name
Autophagy - animal - Propithecus coquereli (Coquerel's sifaka)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
pcoq04140  Autophagy - animal
pcoq04140

Other DBs
GO: 0006914
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804930  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
105804931  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105804954  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105805133  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
105805315  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105805318  RRAGD; ras-related GTP-binding protein D [KO:K16186]
105805400  STX17; syntaxin-17 [KO:K08491]
105805862  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
105806007  [KO:K17445]
105806035  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105806139  RAB1A; ras-related protein Rab-1A [KO:K07874]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806302  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105806394  ATG4C; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
105806636  TSC1; hamartin [KO:K07206]
105807350  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
105807545  KRAS; GTPase KRas [KO:K07827]
105807778  KIAA0226; run domain Beclin-1 interacting and cysteine-rich containing protein isoform X1 [KO:K19330]
105807827  ATG4D; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105807995  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
105808786  ATG9A; autophagy-related protein 9A [KO:K17907]
105808835  IRS1; insulin receptor substrate 1 [KO:K16172]
105808872  EPG5; LOW QUALITY PROTEIN: ectopic P granules protein 5 homolog [KO:K23883]
105809369  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
105809401  RRAS; ras-related protein R-Ras [KO:K07829]
105809864  IGBP1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810128  SUPT20H; transcription factor SPT20 homolog [KO:K21245]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810215  MTMR3; myotubularin-related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
105810278  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
105810299  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105810391  [KO:K10435]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810591  NRAS; GTPase NRas [KO:K07828]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810971  IRS4; insulin receptor substrate 4 [KO:K17446]
105810994  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
105811079  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
105811088  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105811149  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105811307  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105811376  ATG4A; cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
105811511  UVRAG; UV radiation resistance-associated gene protein [KO:K21249]
105811521  ATG16L2; autophagy-related protein 16-2 isoform X1 [KO:K20868]
105811637  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
105811938  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105811986  [KO:K23609]
105812178  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
105812331  RRAGC; ras-related GTP-binding protein C [KO:K16186]
105812498  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
105812594  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812701  WDFY3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105813061  TSC2; tuberin isoform X1 [KO:K07207]
105813066  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105813132  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105813657  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105813662  VMP1; vacuole membrane protein 1 [KO:K21248]
105813676  MTMR4; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
105813802  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814237  VPS39; vam6/Vps39-like protein [KO:K20183]
105814498  EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 isoform X1 [KO:K16196] [EC:2.7.11.1]
105814524  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
105814571  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105814728  [KO:K04570]
105814769  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105814830  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105814986  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105815579  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
105815896  [KO:K03237]
105815928  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
105815999  [KO:K04440] [EC:2.7.11.24]
105816012  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
105816116  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105816430  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
105816531  INS; insulin [KO:K04526]
105816553  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816656  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
105816763  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
105816807  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
105816882  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
105817917  ATG101; autophagy-related protein 101 [KO:K19730]
105818097  [KO:K02927]
105818146  [KO:K02927]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105818692  RAB33B; ras-related protein Rab-33B [KO:K07920]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819008  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
105819240  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
105819401  CFLAR; CASP8 and FADD-like apoptosis regulator [KO:K04724]
105819431  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
105819572  TANK; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
105819700  RAB7A; ras-related protein Rab-7a [KO:K07897]
105819837  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
105819858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105819915  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
105820050  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
105820057  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
105820204  NBR1; next to BRCA1 gene 1 protein [KO:K17987]
105820245  BECN1; beclin-1 isoform X1 [KO:K08334]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820727  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105821039  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105821070  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105821193  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
105821407  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
105822349  ATG16L1; autophagy-related protein 16-1 [KO:K17890]
105822388  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
105822404  CTSL; cathepsin L1 [KO:K01365] [EC:3.4.22.15]
105822406  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
105822546  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
105822702  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823270  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105823477  PRAP1; proline-rich acidic protein 1 [KO:K21250]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823688  OPTN; optineurin isoform X1 [KO:K19946]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105823877  SH3GLB1; endophilin-B1 [KO:K11248]
105823889  [KO:K10802]
105824092  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105824210  RAB39B; ras-related protein Rab-39B [KO:K07925]
105824495  ATG4B; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
105824575  ATG9B; LOW QUALITY PROTEIN: autophagy-related protein 9B [KO:K17907]
105824616  RHEB; GTP-binding protein Rheb [KO:K07208]
105824798  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
105824813  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105824927  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825063  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105825142  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
105825169  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
105825484  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105825561  UBC; polyubiquitin-C [KO:K02927]
105825571  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
105825619  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
105825706  RAB8A; ras-related protein Rab-8A [KO:K07901]
105825918  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105826235  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826559  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105826590  ATG10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
105826598  MRAS; ras-related protein M-Ras [KO:K07831]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826626  WDR41; LOW QUALITY PROTEIN: WD repeat-containing protein 41 [KO:K23610]
105826931  PRKCQ; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
105826962  SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
105827015  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105827041  GORASP1; Golgi reassembly-stacking protein 1 [KO:K26797]
105827070  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105827151  STX7; syntaxin-7 [KO:K08488]
105827252  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827360  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105827410  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
pcoq04010  MAPK signaling pathway
pcoq04141  Protein processing in endoplasmic reticulum
pcoq04142  Lysosome
pcoq04150  mTOR signaling pathway
pcoq04152  AMPK signaling pathway
pcoq04910  Insulin signaling pathway
KO pathway
ko04140   

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