KEGG   PATHWAY: pdic04514
Entry
pdic04514                   Pathway                                
Name
Cell adhesion molecules - Phyllostomus discolor (pale spear-nosed bat)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pdic04514  Cell adhesion molecules
pdic04514

Other DBs
GO: 0050839
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114488726  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
114489147  CD2; T-cell surface antigen CD2 [KO:K06449]
114496083  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
114490597  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
114488801  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
114505992  CD274; programmed cell death 1 ligand 1 [KO:K06745]
114494613  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
114490803  CD86; T-lymphocyte activation antigen CD86 isoform X6 [KO:K05413]
114495171  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
114490718  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
114495511  ICOS; inducible T-cell costimulator [KO:K06713]
114495405  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
114495557  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
114494922  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
114495689  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
114493969  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
114493970  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
114494279  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X2 [KO:K06752]
114494593  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
114494745  SLA class II histocompatibility antigen, DQ haplotype D beta chain-like isoform X1 [KO:K06752]
114494923  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
114513512  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
114509744  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
114510724  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
114510729  HLA class I histocompatibility antigen, alpha chain F-like isoform X2 [KO:K06751]
114510746  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114510749  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510755  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510758  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510764  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510832  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114510833  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510835  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
114510837  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
114510840  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114510842  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510968  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114490215  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114489982  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
114493833  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114493857  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
114493871  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114493931  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114493932  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
114494996  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
114510838  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
114510766  HLA class I histocompatibility antigen, alpha chain F-like [KO:K06751]
114510722  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
114510923  patr class I histocompatibility antigen, alpha chain E-like isoform X1 [KO:K06751]
114510788  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510850  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
114510843  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
114510738  popy class I histocompatibility antigen, alpha chain E-like [KO:K06751]
114510761  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
114510844  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510739  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
114510783  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
114500596  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
114498476  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
114505024  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
114492030  CD276; CD276 antigen isoform X1 [KO:K06746]
114489144  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
114495573  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
114506775  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
114505126  CD40LG; CD40 ligand [KO:K03161]
114489361  ALCAM; CD166 antigen isoform X1 [KO:K06547]
114499120  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
114511446  poliovirus receptor [KO:K06539]
114506622  CD226; CD226 antigen isoform X1 [KO:K06567]
114511315  NECTIN2; nectin-2 isoform X1 [KO:K06531]
114491145  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
114508204  ITGAL; integrin alpha-L isoform X3 [KO:K05718]
114490519  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
114503655  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
114503515  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
114502301  ICAM3; intercellular adhesion molecule 3 isoform X1 [KO:K06486]
114510565  CD22; B-cell receptor CD22 isoform X4 [KO:K06467]
114512483  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
114507026  SIGLEC1; sialoadhesin isoform X2 [KO:K06548]
114506886  SPN; leukosialin [KO:K06477]
114490221  NECTIN3; nectin-3 isoform X1 [KO:K06592]
114507862  CLDN12; claudin-12 [KO:K06087]
114495559  CLDN6; claudin-6 [KO:K06087]
114509671  CLDN5; claudin-5 [KO:K06087]
114505167  CLDN2; claudin-2 [KO:K06087]
114489859  claudin-34-like [KO:K06087]
114495568  CLDN9; claudin-9 [KO:K06087]
114490019  CLDN17; claudin-17 [KO:K06087]
114490063  CLDN8; claudin-8 [KO:K06087]
114497575  CLDN19; claudin-19 [KO:K06087]
114490518  CLDN11; claudin-11 [KO:K06087]
114490538  CLDN1; claudin-1 [KO:K06087]
114497964  CLDN3; claudin-3 [KO:K06087]
114491070  CLDN14; claudin-14 [KO:K06087]
114491100  CLDN16; claudin-16 isoform X1 [KO:K06087]
114498880  CLDN4; claudin-4 [KO:K06087]
114505147  CLDN15; claudin-15 [KO:K06087]
114505563  CLDN34; claudin-34 [KO:K06087]
114515005  CLDN7; claudin-7 [KO:K06087]
114500982  CLDN25; putative claudin-25 [KO:K06087]
114508381  claudin-22-like [KO:K06087]
114508676  CLDN10; claudin-10 isoform X2 [KO:K06087]
114494683  CLDN20; claudin-20 [KO:K06087]
114502013  CLDN18; claudin-18 isoform X1 [KO:K06087]
114508774  CLDN23; claudin-23 [KO:K06087]
114508848  putative claudin-24 [KO:K06087]
114504333  OCLN; occludin [KO:K06088]
114489498  F11R; junctional adhesion molecule A [KO:K06089]
114490601  JAM2; junctional adhesion molecule B [KO:K06735]
114510036  JAM3; junctional adhesion molecule C [KO:K06785]
114509729  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
114488160  CDH5; cadherin-5 isoform X1 [KO:K06533]
114504010  PECAM1; platelet endothelial cell adhesion molecule isoform X4 [KO:K06471]
114489856  CD99 antigen isoform X1 [KO:K06520]
114504838  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
114498140  ITGAM; integrin alpha-M [KO:K06461]
114510080  SELPLG; P-selectin glycoprotein ligand 1 isoform X1 [KO:K06544]
114512149  P-selectin [KO:K06496]
114494684  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
114493428  ITGB1; integrin beta-1 [KO:K05719]
114501968  ITGA9; integrin alpha-9 [KO:K06585]
114488990  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
114513024  ITGB7; integrin beta-7 [KO:K06590]
114503600  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
114512028  SELL; L-selectin isoform X1 [KO:K06495]
114512061  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
114515483  GLG1; Golgi apparatus protein 1 [KO:K06816]
114512038  SELE; E-selectin [KO:K06494]
114498758  NECTIN1; nectin-1 [KO:K06081]
114506242  CDH2; cadherin-2 isoform X1 [KO:K06736]
114498443  NCAM1; neural cell adhesion molecule 1 isoform X8 [KO:K06491]
114491012  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
114505017  L1CAM; neural cell adhesion molecule L1 isoform X4 [KO:K06550]
114498588  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
114497905  NEGR1; neuronal growth regulator 1 [KO:K06775]
114488920  NTNG1; netrin-G1 isoform X4 [KO:K07522]
114499665  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
114501862  NTNG2; netrin-G2 isoform X1 [KO:K16359]
114507541  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
114496525  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X7 [KO:K05695] [EC:3.1.3.48]
114510973  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
114499788  SDC1; syndecan-1 isoform X2 [KO:K06257]
114514497  SDC2; syndecan-2 [KO:K16336]
114497503  SDC3; syndecan-3 [KO:K16337]
114506483  SDC4; syndecan-4 [KO:K16338]
114493963  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
114507565  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
114493248  ITGA8; integrin alpha-8 [KO:K06584]
114492720  NRXN3; LOW QUALITY PROTEIN: neurexin 3 [KO:K07377]
114498500  NRXN1; neurexin-1 isoform X1 [KO:K07377]
114499359  NRXN2; neurexin-2-beta isoform X13 [KO:K07377]
114489861  NLGN4X; neuroligin-4, X-linked [KO:K07378]
114490750  NLGN1; neuroligin-1 isoform X2 [KO:K07378]
114505205  NLGN3; neuroligin-3 isoform X3 [KO:K07378]
114514985  NLGN2; LOW QUALITY PROTEIN: neuroligin-2 [KO:K07378]
114503215  PTPRS; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
114508642  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
114505376  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
114505006  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
114508701  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
114508509  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
114500340  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X35 [KO:K06777] [EC:3.1.3.48]
114491130  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
114511855  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
114507557  NRCAM; neuronal cell adhesion molecule isoform X4 [KO:K06756]
114512818  CNTN1; contactin-1 isoform X1 [KO:K06759]
114506318  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X3 [KO:K05693] [EC:3.1.3.48]
114512063  CNTN2; contactin-2 [KO:K06760]
114512054  NFASC; neurofascin isoform X3 [KO:K06757]
114504272  CNTNAP1; contactin-associated protein 1 [KO:K07379]
114507674  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
114489410  MPZ; myelin protein P0 isoform X1 [KO:K06770]
114511070  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
114488249  CDH1; cadherin-1 [KO:K05689]
114511911  VCAN; versican core protein isoform X1 [KO:K06793]
114494031  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114488091  CDH3; cadherin-3 isoform X1 [KO:K06796]
114506149  CDH4; cadherin-4 [KO:K06797]
114488215  CDH15; cadherin-15 [KO:K06809]
114491806  NEO1; LOW QUALITY PROTEIN: neogenin [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
pdic04520  Adherens junction
pdic04530  Tight junction
pdic04610  Complement and coagulation cascades
pdic04660  T cell receptor signaling pathway
pdic04670  Leukocyte transendothelial migration
KO pathway
ko04514   
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