KEGG   PATHWAY: pdic04530
Entry
pdic04530                   Pathway                                
Name
Tight junction - Phyllostomus discolor (pale spear-nosed bat)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pdic04530  Tight junction
pdic04530

Other DBs
GO: 0005923
Organism
Phyllostomus discolor (pale spear-nosed bat) [GN:pdic]
Gene
114488206  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
114488284  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
114488548  TJP1; tight junction protein ZO-1 isoform X6 [KO:K05701]
114488684  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
114488777  CGN; cingulin [KO:K06102]
114488780  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X2 [KO:K12791]
114488792  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
114488816  RAB13; ras-related protein Rab-13 [KO:K06109]
114488957  RAP1A; ras-related protein Rap-1A [KO:K04353]
114489498  F11R; junctional adhesion molecule A [KO:K06089]
114489859  [KO:K06087]
114489996  CTTN; src substrate cortactin isoform X1 [KO:K06106]
114490019  CLDN17; claudin-17 [KO:K06087]
114490037  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
114490063  CLDN8; claudin-8 [KO:K06087]
114490064  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
114490093  AFDN; afadin isoform X14 [KO:K05702]
114490418  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
114490518  CLDN11; claudin-11 [KO:K06087]
114490538  CLDN1; claudin-1 [KO:K06087]
114490543  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
114490601  JAM2; junctional adhesion molecule B [KO:K06735]
114490980  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
114491046  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
114491070  CLDN14; claudin-14 [KO:K06087]
114491100  CLDN16; claudin-16 isoform X1 [KO:K06087]
114491565  CGNL1; cingulin-like protein 1 isoform X2 [KO:K21110]
114491633  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
114491723  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
114491818  RAB8B; ras-related protein Rab-8B [KO:K07902]
114492318  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
114492422  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114492503  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
114492546  PARD3; partitioning defective 3 homolog isoform X6 [KO:K04237]
114492681  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114492852  [KO:K04354]
114493428  ITGB1; integrin beta-1 [KO:K05719]
114493907  ACTR3; actin-related protein 3 [KO:K18584]
114493998  [KO:K06448]
114494013  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
114494139  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
114494148  MPDZ; multiple PDZ domain protein isoform X2 [KO:K06095]
114494211  [KO:K07374]
114494386  TJP2; tight junction protein ZO-2 isoform X5 [KO:K06098]
114494421  BVES; blood vessel epicardial substance [KO:K21108]
114494438  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114494683  CLDN20; claudin-20 [KO:K06087]
114494728  EZR; ezrin [KO:K08007]
114494782  [KO:K06448]
114494783  [KO:K06448]
114494917  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
114495136  PRKAG3; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
114495174  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
114495258  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
114495310  [KO:K06448]
114495559  CLDN6; claudin-6 [KO:K06087]
114495568  CLDN9; claudin-9 [KO:K06087]
114495658  [KO:K07374]
114496029  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
114496144  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114496184  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114496428  JUN; transcription factor AP-1 [KO:K04448]
114496467  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
114496519  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
114496579  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114497366  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
114497575  CLDN19; claudin-19 [KO:K06087]
114497964  CLDN3; claudin-3 [KO:K06087]
114498131  PATJ; inaD-like protein isoform X1 [KO:K06092]
114498452  DLG2; disks large homolog 2 isoform X2 [KO:K12075]
114498574  RDX; LOW QUALITY PROTEIN: radixin [KO:K05762]
114498743  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
114498880  CLDN4; claudin-4 [KO:K06087]
114499229  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
114499237  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
114499279  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
114499532  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
114499767  EPB41L4B; band 4.1-like protein 4B isoform X3 [KO:K21111]
114500636  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
114500683  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114500982  CLDN25; putative claudin-25 [KO:K06087]
114501349  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19 [KO:K05631]
114501467  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
114501473  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
114501483  RHOA; transforming protein RhoA [KO:K04513]
114501579  AMOTL2; angiomotin-like protein 2 isoform X2 [KO:K06104]
114502013  CLDN18; claudin-18 isoform X1 [KO:K06087]
114502123  [KO:K05758]
114502259  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114502379  TJP3; tight junction protein ZO-3 isoform X1 [KO:K06097]
114502442  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114502459  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
114502660  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
114502909  CRB3; protein crumbs homolog 3 [KO:K06090]
114502923  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
114502952  [KO:K04513]
114502996  MYH11; myosin-11 isoform X1 [KO:K10352]
114503415  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
114503502  RAB8A; ras-related protein Rab-8A [KO:K07901]
114503947  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X6 [KO:K08018]
114504029  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114504099  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
114504186  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
114504333  OCLN; occludin [KO:K06088]
114504505  MSN; moesin [KO:K05763]
114504614  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
114504927  [KO:K06099]
114504948  [KO:K06099]
114505031  AMOT; angiomotin [KO:K16819]
114505147  CLDN15; claudin-15 [KO:K06087]
114505167  CLDN2; claudin-2 [KO:K06087]
114505476  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
114505495  RAP2C; ras-related protein Rap-2c [KO:K07839]
114505563  CLDN34; claudin-34 [KO:K06087]
114506304  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X14 [KO:K13305] [EC:2.3.2.26]
114506335  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114506469  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
114506489  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114506571  [KO:K12757]
114506695  [KO:K12757]
114506701  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
114506714  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
114506817  PCNA; proliferating cell nuclear antigen [KO:K04802]
114507316  [KO:K04393]
114507622  PRKAG2; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
114507755  CFTR; cystic fibrosis transmembrane conductance regulator isoform X4 [KO:K05031] [EC:5.6.1.6]
114507778  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
114507862  CLDN12; claudin-12 [KO:K06087]
114508381  [KO:K06087]
114508573  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
114508676  CLDN10; claudin-10 isoform X2 [KO:K06087]
114508774  CLDN23; claudin-23 [KO:K06087]
114508848  [KO:K06087]
114508871  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114509151  ACTB; actin, cytoplasmic 1 [KO:K05692]
114509174  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114509246  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
114509250  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
114509254  NF2; merlin isoform X3 [KO:K16684]
114509275  [KO:K07374]
114509286  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
114509377  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
114509417  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114509515  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114509586  SYNPO; synaptopodin isoform X1 [KO:K21112]
114509631  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
114509671  CLDN5; claudin-5 [KO:K06087]
114509831  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114510036  JAM3; junctional adhesion molecule C [KO:K06785]
114510062  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
114510140  [KO:K07374]
114510264  MICALL2; MICAL-like protein 2 [KO:K21068]
114510926  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
114511113  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
114511212  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
114511297  SYMPK; symplekin isoform X1 [KO:K06100]
114511328  [KO:K06274]
114511667  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
114512029  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
114512076  [KO:K06448]
114512078  [KO:K06448]
114512339  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
114512626  [KO:K07374]
114512697  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114512770  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X2 [KO:K07200]
114512797  MYL6B; myosin light chain 6B [KO:K12751]
114512798  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
114513013  [KO:K07374]
114513014  [KO:K07374]
114513015  TUBA1C; tubulin alpha-1C chain isoform X2 [KO:K07374]
114513341  [KO:K10352]
114513385  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
114513927  [KO:K10352]
114513932  [KO:K10352]
114514456  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
114514478  [KO:K04802]
114515005  CLDN7; claudin-7 [KO:K06087]
114515014  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
114515070  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114515268  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X3 [KO:K06094]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
pdic04520  Adherens junction
pdic04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

DBGET integrated database retrieval system