KEGG   PATHWAY: pfor03320
Entry
pfor03320                   Pathway                                
Name
PPAR signaling pathway - Poecilia formosa (Amazon molly)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
pfor03320  PPAR signaling pathway
pfor03320

Organism
Poecilia formosa (Amazon molly) [GN:pfor]
Gene
103130063  gk; glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
103130229  [KO:K00864] [EC:2.7.1.30]
103132391  pltp; phospholipid transfer protein isoform X1 [KO:K08761]
103133117  [KO:K08762]
103133485  scd; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103133741  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
103134484  [KO:K07294]
103134814  [KO:K00488] [EC:1.14.15.15]
103135058  fabp3; fatty acid-binding protein, heart [KO:K08752]
103135151  [KO:K08752]
103135318  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
103135563  fabp6; gastrotropin [KO:K08755]
103135748  [KO:K07431] [EC:1.14.14.139]
103136305  pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103137262  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
103137816  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X2 [KO:K01897] [EC:6.2.1.3]
103137823  fabp2; fatty acid-binding protein, intestinal [KO:K08751]
103137842  [KO:K17284]
103138135  [KO:K00488] [EC:1.14.15.15]
103138440  [KO:K08755]
103139182  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00255] [EC:1.3.8.8]
103139575  [KO:K08771]
103139826  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
103139938  acsl4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
103140016  [KO:K08764] [EC:2.3.1.176]
103140224  cd36; platelet glycoprotein 4 [KO:K06259]
103140321  [KO:K00029] [EC:1.1.1.40]
103140564  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
103141189  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
103141299  [KO:K10226] [EC:1.14.19.3]
103141300  [KO:K10226] [EC:1.14.19.3]
103141301  [KO:K10226] [EC:1.14.19.3]
103141428  [KO:K08762]
103141782  [KO:K08750]
103141786  [KO:K08750]
103141998  [KO:K15013] [EC:6.2.1.3]
103142291  [KO:K00507] [EC:1.14.19.1]
103142585  [KO:K08526]
103143393  plin2; perilipin-2 [KO:K17284]
103143583  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103143584  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103143842  [KO:K08767]
103144236  [KO:K08753]
103144435  [KO:K08765] [EC:2.3.1.21]
103144574  rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103145193  [KO:K08751]
103145233  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
103145801  [KO:K01897] [EC:6.2.1.3]
103146397  [KO:K08525]
103146742  fabp7; fatty acid-binding protein, brain [KO:K08756]
103146882  [KO:K08761]
103147838  slc27a4; long-chain fatty acid transport protein 4 isoform X1 [KO:K08745] [EC:6.2.1.-]
103148069  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
103148272  [KO:K06086]
103148510  [KO:K06272] [EC:2.7.11.1]
103148586  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
103148850  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
103148966  [KO:K01897] [EC:6.2.1.3]
103149216  [KO:K08765] [EC:2.3.1.21]
103149704  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
103150406  [KO:K08524]
103150606  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
103150791  [KO:K08758]
103151705  [KO:K01897] [EC:6.2.1.3]
103151771  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
103152010  slc27a1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
103152202  [KO:K01897] [EC:6.2.1.3]
103152276  [KO:K08753]
103153035  angptl4; angiopoietin-related protein 4 [KO:K08767]
103153199  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X2 [KO:K00232] [EC:1.3.3.6]
103153230  hmgcs1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:2.3.3.10]
103154100  dbi; acyl-CoA-binding protein [KO:K08762]
103154130  [KO:K00488] [EC:1.14.15.15]
103154146  [KO:K08745] [EC:6.2.1.-]
103155067  [KO:K08756]
103155076  [KO:K08756]
103155087  [KO:K06276] [EC:2.7.11.1]
103155091  [KO:K06276] [EC:2.7.11.1]
103155279  [KO:K17284]
103155706  [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103155729  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103156231  ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
103156348  [KO:K00489] [EC:1.14.14.23]
103156444  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
103156827  [KO:K08765] [EC:2.3.1.21]
103156884  lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103156885  [KO:K01059] [EC:3.1.1.34]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
pfor00071  Fatty acid degradation
pfor00120  Primary bile acid biosynthesis
pfor00564  Glycerophospholipid metabolism
pfor04920  Adipocytokine signaling pathway
KO pathway
ko03320   

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