KEGG PATHWAY: pst00260

PATHWAY: pst00260

Entry

pst00260                    Pathway

Name

Glycine, serine and threonine metabolism - Pseudomonas syringae pv. tomato DC3000

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

pst00260

Glycine, serine and threonine metabolism

Module

pst_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pst00260]

pst_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:pst00260]

pst_M00555

Betaine biosynthesis, choline => betaine [PATH:pst00260]

pst_M00621

Glycine cleavage system [PATH:pst00260]

pst_M00975

Betaine degradation, bacteria, betaine => pyruvate [PATH:pst00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Pseudomonas syringae pv. tomato DC3000 [GN:pst]

Gene

PSPTO_0158

trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

PSPTO_0159

trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

PSPTO_0258

[KO:K12972] [EC:1.1.1.79 1.1.1.81]

PSPTO_0316

gcvT-1; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

PSPTO_0317

gcvH-1; glycine cleavage system H protein [KO:K02437]

PSPTO_0346

thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]

PSPTO_0396

[KO:K21833] [EC:1.5.7.3]

PSPTO_0397

[KO:K21834]

PSPTO_0398

etfA-1; electron transfer flavoprotein, alpha subunit [KO:K25960]

PSPTO_0399

etfB-1; electron transfer flavoprotein, beta subunit [KO:K25961]

PSPTO_0401

[KO:K00479] [EC:1.14.13.251]

PSPTO_0402

[KO:K21832] [EC:1.14.13.251]

PSPTO_0410

[KO:K01620] [EC:4.1.2.48]

PSPTO_0441

betB; betaine aldehyde dehydrogenase BADH [KO:K00130] [EC:1.2.1.8]

PSPTO_0443

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

PSPTO_0457

soxG-1; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]

PSPTO_0458

soxA-1; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

PSPTO_0459

soxD-1; sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

PSPTO_0460

soxB-1; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]

PSPTO_0461

glyA-1; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

PSPTO_0873

[KO:K00613] [EC:2.1.4.1]

PSPTO_0984

pssA-1; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

PSPTO_1215

[KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]

PSPTO_1275

gcvT-2; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]

PSPTO_1276

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

PSPTO_1277

gcvH-2; glycine cleavage system H protein [KO:K02437]

PSPTO_1480

hom; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

PSPTO_1481

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

PSPTO_1746

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

PSPTO_1841

[KO:K01620] [EC:4.1.2.48]

PSPTO_1843

[KO:K00928] [EC:2.7.2.4]

PSPTO_1886

sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]

PSPTO_2136

daT; 2,4-diaminobutyrate 4-transaminase [KO:K00836] [EC:2.6.1.76]

PSPTO_2176

asd-1; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

PSPTO_2201

lpdA; 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

PSPTO_2281

[KO:K02203] [EC:3.1.3.3 2.7.1.39]

PSPTO_2427

[KO:K00600] [EC:2.1.2.1]

PSPTO_2430

[KO:K01697] [EC:4.2.1.22]

PSPTO_2449

soxG-2; sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]

PSPTO_2450

soxA-2; sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]

PSPTO_2451

soxD-2; sarcosine oxidase, delta subunit [KO:K00304] [EC:1.5.3.24 1.5.3.1]

PSPTO_2452

soxB-2; sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]

PSPTO_3007

[KO:K00274] [EC:1.4.3.4]

PSPTO_3062

[KO:K00479] [EC:1.14.13.251]

PSPTO_3280

glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]

PSPTO_3327

[KO:K00301] [EC:1.5.3.1]

PSPTO_3463

pssA-2; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]

PSPTO_3806

ilvA-1; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]

PSPTO_4632

glyA-2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

PSPTO_4914

[KO:K16066] [EC:1.1.1.381 1.1.1.-]

PSPTO_4957

[KO:K01079] [EC:3.1.3.3]

PSPTO_5074

[KO:K00274] [EC:1.4.3.4]

PSPTO_5288

ilvA-2; threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]

PSPTO_5294

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

PSPTO_5327

gpmA; phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721