KEGG   PATHWAY: ptao04350
Entry
ptao04350                   Pathway                                
Name
TGF-beta signaling pathway - Phyllopteryx taeniolatus (common seadragon)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
ptao04350  TGF-beta signaling pathway
ptao04350

Other DBs
GO: 0007179
Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133464954  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
133465084  [KO:K04666]
133465736  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
133465743  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
133465777  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
133465816  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
133465909  nog1; noggin-1 [KO:K04658]
133466092  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133466127  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
133466859  smad9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
133467102  fbn1; fibrillin-1 [KO:K06825]
133467157  lrrc32; transforming growth factor beta activator LRRC32 isoform X1 [KO:K26316]
133467194  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
133467195  skp1; S-phase kinase-associated protein 1 [KO:K03094]
133467544  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
133467607  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
133468262  bmp2b; bone morphogenetic protein 2b [KO:K21283]
133468306  grem1a; gremlin-1a [KO:K23318]
133468353  lft1; lefty1 [KO:K04668]
133468541  thbs1b; thrombospondin-1 [KO:K16857]
133468619  [KO:K13377]
133469118  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
133469337  [KO:K21283]
133469444  [KO:K04666]
133469616  nog2; noggin-2 [KO:K04658]
133469959  myca; transcriptional regulator Myc-A [KO:K04377]
133470021  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
133470115  tfr1b; transferrin receptor 1b [KO:K06503]
133470130  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
133470204  bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
133470271  [KO:K03347]
133470276  inhbaa; inhibin subunit beta Aa [KO:K04667]
133470334  tgif1; homeobox protein TGIF1 [KO:K19383]
133470398  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a isoform X1 [KO:K10162]
133470729  gdf6b; growth/differentiation factor 6-B [KO:K20012]
133470860  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
133470890  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
133470953  [KO:K04677]
133470963  [KO:K23605]
133471023  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
133471064  bmp8a; bone morphogenetic protein 8A [KO:K16622]
133471264  [KO:K06067] [EC:3.5.1.98]
133471532  neo1a; neogenin 1a isoform X1 [KO:K06766]
133471642  [KO:K11644]
133471739  dcn; decorin [KO:K04660]
133471872  [KO:K28359]
133471989  lemd3; inner nuclear membrane protein Man1 [KO:K19410]
133474132  [KO:K23377]
133474713  [KO:K04500]
133474857  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133474940  [KO:K13578] [EC:2.7.11.30]
133475107  fsta; follistatin-A isoform X1 [KO:K04661]
133475289  [KO:K04501]
133475359  rgmb; RGM domain family member B [KO:K06847]
133475500  spaw; southpaw [KO:K04666]
133475816  [KO:K04382] [EC:3.1.3.16]
133476285  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
133476828  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
133476908  smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
133477410  [KO:K04688] [EC:2.7.11.1]
133477524  [KO:K04678] [EC:2.3.2.26]
133477926  rgma; repulsive guidance molecule A [KO:K23096]
133477967  [KO:K11644]
133478102  [KO:K04513]
133478136  si:dkey-5i3.5; uncharacterized protein si:dkey-5i3.5 isoform X1 [KO:K28359]
133478459  smad6b; mothers against decapentaplegic homolog 6b isoform X1 [KO:K04677]
133478470  smad3b; mothers against decapentaplegic homolog 3b isoform X1 [KO:K23605]
133478473  acvr1ba; activin A receptor type 1Ba isoform X1 [KO:K13567] [EC:2.7.11.30]
133478665  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
133479201  [KO:K04670] [EC:2.7.11.30]
133479528  gdf6a; growth/differentiation factor 6-A [KO:K20012]
133479548  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
133479627  [KO:K23106]
133479953  hamp; hepcidin-1 [KO:K23106]
133480076  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
133480087  [KO:K23106]
133480088  [KO:K23106]
133480089  [KO:K23106]
133480799  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
133480966  [KO:K22687]
133481102  rgmd; RGM domain family, member D isoform X1 [KO:K23096]
133481178  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
133481344  amh; muellerian-inhibiting factor [KO:K04665]
133481991  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
133482095  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
133482292  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
133482506  chrd; chordin isoform X1 [KO:K04657]
133482637  bmp16; bone morphogenetic protein 16 [KO:K21283]
133482716  [KO:K26257]
133483050  emp3a; epithelial membrane protein 3 [KO:K26257]
133483220  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
133483239  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
133483373  [KO:K04513]
133483555  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
133483626  [KO:K04671] [EC:2.7.11.30]
133483762  [KO:K13567] [EC:2.7.11.30]
133483979  nbl1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
133483995  [KO:K16621]
133484015  [KO:K19553]
133484025  [KO:K22687]
133484073  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
133484088  fmoda; fibromodulin a [KO:K08121]
133484190  [KO:K04513]
133484564  [KO:K04382] [EC:3.1.3.16]
133484883  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
133485051  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
133485103  [KO:K26316]
133485166  smad5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
133485381  ltbp1; LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 1 [KO:K19559]
133485546  [KO:K04673] [EC:2.7.11.30]
133486047  bmp5; bone morphogenetic protein 5 [KO:K04663]
133486238  grem2a; gremlin-2 [KO:K23318]
133486353  [KO:K04388] [EC:2.7.11.30]
133486653  [KO:K04675] [EC:2.7.11.30]
133486725  [KO:K04683]
133486779  [KO:K04513]
133486882  skia; v-ski avian sarcoma viral oncogene homolog a isoform X1 [KO:K26503]
133486922  [KO:K13568] [EC:2.7.11.30]
133486986  inhbb; inhibin beta B chain [KO:K22687]
133487402  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
133487497  [KO:K06067] [EC:3.5.1.98]
133487669  bmp7b; bone morphogenetic protein 7b [KO:K16621]
133487708  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
133487730  [KO:K23318]
133487979  [KO:K16857]
133488091  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
133488099  bmp4; bone morphogenetic protein 4 [KO:K04662]
133488128  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
133488509  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
133488684  [KO:K14736]
133488685  [KO:K14736]
133488686  [KO:K14736]
133488687  [KO:K14736]
133488724  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
133488869  inhbab; inhibin subunit beta Ab [KO:K04667]
133489200  [KO:K14736]
133489311  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
133489317  admp; anti-dorsalizing morphogenic protein [KO:K21283]
133489354  tmem53; transmembrane protein 53 [KO:K28359]
133489395  skila; ski-like protein isoform X1 [KO:K18499]
133489464  e2f5; transcription factor E2F5 [KO:K04682]
133489535  tfr1a; transferrin receptor 1a isoform X1 [KO:K06503]
133489798  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
133489984  smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
133490062  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
133490273  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
ptao04010  MAPK signaling pathway
ptao04110  Cell cycle
ptao04120  Ubiquitin mediated proteolysis
ptao04210  Apoptosis
KO pathway
ko04350   

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