Entry Name Lysosome - Pan troglodytes (chimpanzee)
Description Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class Cellular Processes; Transport and catabolismBRITE hierarchy
Pathway map Other DBs Organism Pan troglodytes (chimpanzee) [GN:
ptr ]
Gene 100610064 ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X2 [KO:K03661 ]
100611553 ABCA2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642 ]
101058287 GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404 ]
450192 NPC2; NPC intracellular cholesterol transporter 2 isoform X1 [KO:K13443 ]
451897 SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398 ]
452176 GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239 ] [EC:2.7.8.17 ]
452335 ABCB9; ABC-type oligopeptide transporter ABCB9 isoform X1 [KO:K05656 ]
452354 ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154 ]
452607 CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X2 [KO:K12390 ]
453432 AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400 ]
453837 ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c isoform X1 [KO:K02155 ]
453894 NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X2 [KO:K01125 ] [EC:3.1.4.45 ]
453923 LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363 ]
454228 AP1G1; AP-1 complex subunit gamma-1 isoform X2 [KO:K12391 ]
454285 MEAK7; MTOR-associated protein MEAK7 isoform X2 [KO:K27947 ]
454685 ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X2 [KO:K02154 ]
454844 ARSG; arylsulfatase G isoform X3 [KO:K12381 ] [EC:3.1.6.-]
454877 GGA3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404 ]
455338 NPC1; NPC intracellular cholesterol transporter 1 isoform X2 [KO:K12385 ]
455565 AP3D1; AP-3 complex subunit delta-1 isoform X2 [KO:K12396 ]
455710 AP1M2; AP-1 complex subunit mu-2 isoform X6 [KO:K12393 ]
456693 LAPTM5; lysosomal-associated transmembrane protein 5 isoform X1 [KO:K12387 ]
457138 AP4B1; AP-4 complex subunit beta-1 isoform X2 [KO:K12401 ]
458648 CLTCL1; clathrin heavy chain 2 isoform X11 [KO:K04646 ]
458967 AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392 ]
459051 LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387 ]
459979 AP1S3; AP-1 complex subunit sigma-3 isoform X1 [KO:K12395 ]
461789 AP3B1; AP-3 complex subunit beta-1 isoform X4 [KO:K12397 ]
462926 CD164; sialomucin core protein 24 isoform X1 [KO:K06546 ]
462982 NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442 ]
463112 IGF2R; cation-independent mannose-6-phosphate receptor isoform X1 [KO:K06564 ]
463765 ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154 ]
464056 ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305 ] [EC:3.6.1.6 ]
466895 TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X2 [KO:K02154 ]
467407 AP1G2; AP-1 complex subunit gamma-like 2 isoform X9 [KO:K12391 ]
467417 AP4S1; AP-4 complex subunit sigma-1 isoform X3 [KO:K12403 ]
468545 WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738 ]
471303 MFSD8; major facilitator superfamily domain-containing protein 8 isoform X6 [KO:K12307 ]
471606 AP3S1; AP-3 complex subunit sigma-1 isoform X3 [KO:K12399 ]
472747 AP3M2; AP-3 complex subunit mu-2 isoform X1 [KO:K12398 ]
472809 ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146 ]
736013 M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089 ]
737597 LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
737954 LAMP1; lysosome-associated membrane glycoprotein 1 precursor [KO:K06528 ]
738038 AP4M1; AP-4 complex subunit mu-1 isoform X2 [KO:K12402 ]
740229 ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144 ]
740230 LAPTM4B; LOW QUALITY PROTEIN: lysosomal-associated transmembrane protein 4B [KO:K12387 ]
740281 ATP6AP1; V-type proton ATPase subunit S1 precursor [KO:K03662 ]
741434 SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347 ]
741872 ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146 ]
742189 AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397 ]
744307 GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404 ]
746034 GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087 ]
746899 LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562 ]
Compound Reference Authors Eskelinen EL, Tanaka Y, Saftig P
Title At the acidic edge: emerging functions for lysosomal membrane proteins.
Journal Reference Authors Neufeld EF
Title Lysosomal storage diseases.
Journal Reference Authors von Figura K, Hasilik A
Title Lysosomal enzymes and their receptors.
Journal Reference Authors Janvier K, Bonifacino JS
Title Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
Journal Reference Authors Vergarajauregui S, Puertollano R
Title Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
Journal Reference Authors Jaskolka MC, Winkley SR, Kane PM
Title RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
Journal Reference Authors Majdoul S, Compton AA
Title Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
Journal Related ptr04130 SNARE interactions in vesicular transport
KO pathway
