KEGG   PATHWAY: pvt04350
Entry
pvt04350                    Pathway                                
Name
TGF-beta signaling pathway - Pogona vitticeps (central bearded dragon)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvt04350  TGF-beta signaling pathway
pvt04350

Other DBs
GO: 0007179
Organism
Pogona vitticeps (central bearded dragon) [GN:pvt]
Gene
110089826  CHRD; chordin [KO:K04657]
110086928  noggin-2-like [KO:K04658]
110075090  NOG; noggin [KO:K04658]
110075926  noggin-like [KO:K04658]
110073208  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
110071823  gremlin-1-like isoform X1 [KO:K23318]
110075791  GREM2; gremlin-2 [KO:K23318]
110085755  GREM1; gremlin-1 [KO:K23318]
110080127  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
110069841  DCN; decorin [KO:K04660]
110080742  FMOD; fibromodulin [KO:K08121]
110075398  LEFTY1; left-right determination factor 1 [KO:K04668]
110073924  FST; follistatin isoform X1 [KO:K04661]
110078983  BMP2; bone morphogenetic protein 2 [KO:K21283]
110088535  bone morphogenetic protein 2-like [KO:K21283]
110072653  bone morphogenetic protein 2-like [KO:K21283]
110089746  BMP4; bone morphogenetic protein 4 [KO:K04662]
110080862  BMP6; bone morphogenetic protein 6 [KO:K16620]
110085665  INHBB; inhibin beta B chain [KO:K22687]
110075272  ovotransferrin-like [KO:K14736]
110073014  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
110081072  BMP7; bone morphogenetic protein 7 [KO:K16621]
110082757  bone morphogenetic protein 8A-like [KO:K16622]
110073324  GDF5; growth/differentiation factor 5 [KO:K04664]
110074753  GDF6; growth/differentiation factor 6 [KO:K20012]
110074239  GDF7; growth/differentiation factor 7 [KO:K20013]
110070405  muellerian-inhibiting factor-like [KO:K04665]
110072647  AMH; muellerian-inhibiting factor [KO:K04665]
110075093  interferon gamma-like [KO:K04687]
110069889  TNF; tumor necrosis factor [KO:K03156]
110074557  THSD4; thrombospondin type-1 domain-containing protein 4 [KO:K23377]
110077221  FBN1; fibrillin-1 isoform X1 [KO:K06825]
110089038  latent-transforming growth factor beta-binding protein 1-like [KO:K19559]
110083923  latent-transforming growth factor beta-binding protein 1-like [KO:K19559]
110088538  TGFB1; transforming growth factor beta-1 [KO:K13375]
110087066  TGFB2; transforming growth factor beta-2 [KO:K13376]
110083352  transforming growth factor beta-2-like [KO:K13376]
110079121  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
110086671  INHBA; inhibin beta A chain [KO:K04667]
110070913  inhibin beta C chain-like [KO:K22688]
110070903  INHBE; inhibin beta E chain [KO:K22689]
110073664  NODAL; nodal homolog isoform X1 [KO:K04666]
110075194  nodal homolog 2-A-like [KO:K04666]
110085621  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
110070404  bone morphogenetic protein receptor type-1A-like [KO:K04673] [EC:2.7.11.30]
110081721  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
110083054  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
110088189  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
110074952  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
110071098  hemojuvelin-like [KO:K23100]
110081445  HFE2; hemojuvelin [KO:K23100]
110084378  NEO1; neogenin [KO:K06766]
110082354  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
110091399  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
110088606  RGMA; repulsive guidance molecule A [KO:K23096]
110078775  RGMB; RGM domain family member B [KO:K06847]
110074443  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
110070403  anti-Muellerian hormone type-2 receptor-like [KO:K04672] [EC:2.7.11.30]
110086076  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110090113  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
110086832  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
110081864  EMP3; epithelial membrane protein 3 [KO:K26257]
110088540  LRRC32; leucine-rich repeat-containing protein 32 isoform X1 [KO:K26316]
110075261  NRROS; negative regulator of reactive oxygen species [KO:K26317]
110074424  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
110071927  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
110083042  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
110082950  BAMBI; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
110073630  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
110073456  SMAD5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
110074026  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
110085053  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110088492  mothers against decapentaplegic homolog 4-like [KO:K04501]
110088634  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
110081056  mothers against decapentaplegic homolog 6-like [KO:K04677]
110087992  SMAD6; mothers against decapentaplegic homolog 6 [KO:K04677]
110085055  SMAD7; mothers against decapentaplegic homolog 7 [KO:K19631]
110073327  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
110087204  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
110076159  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
110077328  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
110076073  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
110088676  CUL1; cullin-1 isoform X1 [KO:K03347]
110079401  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
110081803  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110088651  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110076866  RHOA; transforming protein RhoA [KO:K04513]
110081153  transforming protein RhoA-like [KO:K04513]
110079445  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110086512  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110079404  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110087364  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110075522  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
110085635  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110070230  HAMP; hepcidin [KO:K23106]
110086163  ID3; DNA-binding protein inhibitor ID-3 isoform X1 [KO:K17694]
110072922  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
110073353  RBL1; retinoblastoma-like protein 1 [KO:K04681]
110088596  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
110086867  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
110074146  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
110089145  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110076024  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
110074383  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
110079044  SKIL; ski-like protein isoform X1 [KO:K18499]
110091004  SKI; ski oncogene isoform X1 [KO:K26503]
110074533  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
110088770  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
110082788  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110087388  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
110079442  TGIF1; homeobox protein TGIF1 [KO:K19383]
110083032  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
110085305  MYC; myc proto-oncogene protein [KO:K04377]
110077364  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
110077365  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
110072240  pituitary homeobox 2-like [KO:K04686]
110083594  PITX2; pituitary homeobox 2 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
pvt04010  MAPK signaling pathway
pvt04110  Cell cycle
pvt04120  Ubiquitin mediated proteolysis
pvt04210  Apoptosis
KO pathway
ko04350   
LinkDB

DBGET integrated database retrieval system