Entry Name Folate transport and metabolism - Rattus norvegicus (rat)
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map rno04981 Folate transport and metabolism
Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 116721 Abcc5; ATP-binding cassette sub-family C member 5 [KO:K05668 ]
140668 Abcc3; ATP-binding cassette sub-family C member 3 [KO:K05667 ]
140860 Slco2b1; solute carrier organic anion transporter family member 2B1 [KO:K14352 ]
170924 Abcc4; ATP-binding cassette subfamily C member 4 [KO:K05673 ]
25303 Abcc2; ATP-binding cassette sub-family C member 2 [KO:K05666 ]
29509 Slc22a6; solute carrier family 22 member 6 [KO:K08203 ]
299857 Shmt2; serine hydroxymethyltransferase, mitochondrial isoform 1 [KO:K00600 ] [EC:2.1.2.1 ]
303333 Slc46a1; proton-coupled folate transporter [KO:K14613 ]
312382 Abcg2; broad substrate specificity ATP-binding cassette transporter ABCG2 [KO:K05681 ]
362657 Mthfr; methylenetetrahydrofolate reductase [KO:K25004 ]
58978 Slco1b2; solute carrier organic anion transporter family member 1B2 isoform 1 [KO:K05043 ]
Compound C00019 S-Adenosyl-L-methionine
C00021 S-Adenosyl-L-homocysteine
C00143 5,10-Methylenetetrahydrofolate
C00440 5-Methyltetrahydrofolate
C00445 5,10-Methenyltetrahydrofolate
Reference Authors Alam C, Kondo M, O'Connor DL, Bendayan R
Title Clinical Implications of Folate Transport in the Central Nervous System.
Journal Reference Authors Akiyama T, Kuki I, Kim K, Yamamoto N, Yamada Y, Igarashi K, Ishihara T, Hatano Y, Kobayashi K
Title Folic acid inhibits 5-methyltetrahydrofolate transport across the blood-cerebrospinal fluid barrier: Clinical biochemical data from two cases.
Journal Reference Authors Visentin M, Diop-Bove N, Zhao R, Goldman ID
Title The intestinal absorption of folates.
Journal Reference Authors Ledowsky C, Mahimbo A, Scarf V, Steel A
Title Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review.
Journal Reference Authors Zarou MM, Vazquez A, Vignir Helgason G
Title Folate metabolism: a re-emerging therapeutic target in haematological cancers.
Journal Reference Authors Bekdash RA
Title Methyl Donors, Epigenetic Alterations, and Brain Health: Understanding the Connection.
Journal Reference Authors Steinfeld R, Grapp M, Kraetzner R, Dreha-Kulaczewski S, Helms G, Dechent P, Wevers R, Grosso S, Gartner J
Title Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism.
Journal Reference Authors Sternbach S, West N, Singhal NK, Clements R, Basu S, Tripathi A, Dutta R, Freeman EJ, McDonough J
Title The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation.
Journal Reference Authors Shulpekova Y, Nechaev V, Kardasheva S, Sedova A, Kurbatova A, Bueverova E, Kopylov A, Malsagova K, Dlamini JC, Ivashkin V
Title The Concept of Folic Acid in Health and Disease.
Journal Reference Authors Mafi S, Laroche-Raynaud C, Chazelas P, Lia AS, Derouault P, Sturtz F, Baaj Y, Froget R, Rio M, Benoist JF, Poumeaud F, Favreau F, Faye PA
Title Pharmacoresistant Epilepsy in Childhood: Think of the Cerebral Folate Deficiency, a Treatable Disease.
Journal Related KO pathway
