KEGG   PATHWAY: rno04144
Entry
rno04144                    Pathway                                
Name
Endocytosis - Rattus norvegicus (rat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
rno04144  Endocytosis
rno04144

Other DBs
GO: 0006897
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100359642  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
100361891  Rab5al1; ras-related protein Rab-5A [KO:K07887]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
102549158  [KO:K17917]
108348108  Hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
108348178  Vps37c; vacuolar protein sorting-associated protein 37C isoform 1 [KO:K12185]
116561  Cltb; clathrin light chain B [KO:K04645]
116563  Ap2m1; AP-2 complex subunit mu [KO:K11826]
116691  Cyth1; cytohesin-1 [KO:K18441]
116692  Cyth2; cytohesin-2 isoform 1 [KO:K18441]
116693  Cyth3; cytohesin-3 [KO:K18441]
116743  Sh3gl2; endophilin-A1 [KO:K11247]
117028  Bin1; myc box-dependent-interacting protein 1 [KO:K12562]
117029  Ccr5; C-C chemokine receptor type 5 [KO:K04180]
117103  Rab8a; ras-related protein Rab-8A [KO:K07901]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117277  Epn1; epsin-1 [KO:K12471]
117538  Wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
117550  Kif5b; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
140670  Ap2b1; AP-2 complex subunit beta [KO:K11825]
140694  Dnm1; dynamin-1 [KO:K01528] [EC:3.6.5.5]
140924  Il2rg; cytokine receptor common subunit gamma precursor [KO:K05070]
140940  Arf3; ADP-ribosylation factor 3 [KO:K07938]
171049  Folr1; folate receptor alpha precursor [KO:K13649]
171136  Cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
171381  Psd; PH and SEC7 domain-containing protein 1 [KO:K12494]
171565  Stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
171574  Dnm3; dynamin-3 [KO:K01528] [EC:3.6.5.5]
192204  Ehd4; EH domain-containing protein 4 [KO:K12477]
192249  Ehd3; EH domain-containing protein 3 [KO:K12476]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24468  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
24472  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
246310  Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 [KO:K12492]
246324  Rab31; ras-related protein Rab-31 [KO:K07891]
246772  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24963  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
25096  Pld1; phospholipase D1 isoform 2 [KO:K01115] [EC:3.1.4.4]
25097  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
25151  Igf2r; cation-independent mannose-6-phosphate receptor precursor [KO:K06564]
25238  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
25372  Grk3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
25387  Arrb1; beta-arrestin-1 [KO:K04439]
25388  Arrb2; beta-arrestin-2 [KO:K04439]
25404  Cav1; caveolin-1 isoform alpha [KO:K06278]
25479  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
25489  Nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
25522  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
25532  Rab4a; ras-related protein Rab-4A [KO:K07879]
25631  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
25704  Il2ra; interleukin-2 receptor subunit alpha precursor [KO:K05068]
25718  Igf1r; insulin-like growth factor 1 receptor isoform 2 precursor [KO:K05087] [EC:2.7.10.1]
25746  Il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069]
25751  Dnm2; dynamin-2 [KO:K23484]
259242  Wipf3; WAS/WASL-interacting protein family member 3 isoform 2 [KO:K19475]
282834  Chmp3; charged multivesicular body protein 3 [KO:K12193]
287443  Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
287645  Snf8; vacuolar-sorting protein SNF8 [KO:K12188]
287709  Rab5c; ras-related protein Rab-5C [KO:K07889]
287873  Chmp6; charged multivesicular body protein 6 [KO:K12195]
288659  Vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
288666  Vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
288669  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
288700  Rab35; ras-related protein Rab-35 [KO:K07876]
288779  Rab5b; ras-related protein Rab-5B [KO:K07888]
289820  Actr2; actin-related protein 2 [KO:K17260]
290635  Mvb12a; multivesicular body subunit 12A [KO:K12186]
290775  Vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
290851  Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
291464  Snx2; sorting nexin-2 [KO:K17917]
291553  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
29161  Cav3; caveolin-3 [KO:K12959]
292156  Sh3glb1; endophilin-B1 [KO:K11248]
292640  Vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform 2 [KO:K12199]
292699  Cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
292925  Tsg101; tumor susceptibility gene 101 protein [KO:K12183]
293154  Folr2; folate receptor beta precursor [KO:K13649]
29324  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
29357  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
293621  Hras; GTPase HRas [KO:K02833]
293692  Ehd1; EH domain-containing protein 1 [KO:K12483]
29385  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
29448  Rab7a; ras-related protein Rab-7a [KO:K07897]
295053  Spart; spartin [KO:K19366]
29591  Tgfbr1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
296121  Usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
296199  Snx5; sorting nexin-5 [KO:K17920]
296380  Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
296710  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
297518  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
297530  Washc2c; WASH complex subunit 2 [KO:K18462]
297930  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
297995  Chmp5; charged multivesicular body protein 5 [KO:K12198]
298500  Smap2; stromal membrane-associated protein 2 [KO:K12486]
298584  Capzb; F-actin-capping protein subunit beta [KO:K10365]
299707  Washc3; WASH complex subunit 3 [KO:K18463]
300052  Vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
300438  Ldlr; low-density lipoprotein receptor precursor [KO:K12473]
300472  Vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
300791  Spg21; maspardin isoform 3 [KO:K19367]
301511  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
303002  Rab11fip3; rab11 family-interacting protein 3 [KO:K12485]
303337  Rab11fip4; rab11 family-interacting protein 4 [KO:K12485]
303614  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
304546  Git2; ARF GTPase-activating protein GIT2 [KO:K12487]
305367  Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
306380  Psd3; PH and SEC7 domain-containing protein 3 [KO:K12494]
307237  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
307500  Psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
307799  Pard6a; partitioning defective 6 homolog alpha isoform 1 [KO:K06093]
307833  Ist1; IST1 homolog [KO:K19476]
308003  Rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
308578  Ap2a1; AP-2 complex subunit alpha-1 isoform 1 [KO:K11824]
309376  Zfyve27; protrudin [KO:K19368]
309419  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
309451  Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
311024  Kif5c; kinesin heavy chain isoform 5C [KO:K10396] [EC:5.6.1.3]
311030  Stam2; signal transducing adapter molecule 2 [KO:K04705]
311245  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
311567  Itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
311785  Psd4; PH and SEC7 domain-containing protein 4 [KO:K12494]
311848  Sh3glb2; endophilin-B2 isoform 2 [KO:K21269]
312502  Rab11fip5; rab11 family-interacting protein 5 [KO:K12484]
312562  Rbsn; rabenosyn-5 [KO:K12481]
312915  Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
313409  Dnajc6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
313474  Eps15; epidermal growth factor receptor substrate 15 [KO:K12472]
313477  Zfyve9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
313772  Acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
314641  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c [KO:K00889] [EC:2.7.1.68]
314690  Washc4; WASH complex subunit 4 [KO:K18465]
314764  Eea1; early endosome antigen 1 isoform X1 [KO:K12478]
314856  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
314906  Kif5a; kinesin heavy chain isoform 5A [KO:K10396] [EC:5.6.1.3]
314961  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
315713  Pml; PML nuclear body scaffold [KO:K10054] [EC:2.3.2.-]
316611  Agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1 [KO:K12491]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360521  Rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
360605  Epn3; epsin-3 [KO:K12471]
360620  Wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
360725  Snx4; sorting nexin-4 [KO:K17919]
360834  Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
360854  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
361120  Eps15l1; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
361314  Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
361512  Ehd2; EH domain-containing protein 2 [KO:K12469]
361617  Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
361708  Snx32; sorting nexin-32 isoform X1 [KO:K17920]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
361846  Vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
361916  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
362118  Mvb12b; multivesicular body subunit 12B [KO:K12186]
362162  Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
362279  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
362298  Actr3b; actin-related protein 3B [KO:K18584]
362300  Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
362719  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
362738  Snx6; sorting nexin-6 [KO:K17920]
362814  Rnf41; E3 ubiquitin-protein ligase NRDP1 isoform 1 [KO:K11981] [EC:2.3.2.27]
362919  Washc5; WASH complex subunit 5 [KO:K18464]
363425  Cav2; caveolin-2 [KO:K12958]
363478  Snx12; sorting nexin-12 [KO:K17918]
363487  Chmp1b2; charged multivesicular body protein 1B2 [KO:K12197]
363720  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
364419  Chmp7; charged multivesicular body protein 7 [KO:K15053]
365024  Chmp1a; charged multivesicular body protein 1a [KO:K12197]
365191  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365865  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
366265  Rab22a; ras-related protein Rab-22A [KO:K07891]
367328  Washc1; WASH complex subunit 1 [KO:K18461]
367858  Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
404781  Iqsec3; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
493810  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
498650  Rab11fip1; rab11 family-interacting protein 1 isoform 2 [KO:K12484]
498798  Stam; signal transducing adapter molecule 1 [KO:K04705]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
499508  Zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
500564  Ldlrap1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
500906  Cyth4; cytohesin-4 isoform 2 [KO:K18441]
500985  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
501083  Pdcd6ip; programmed cell death 6-interacting protein [KO:K12200]
503165  Arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
50993  Rab10; ras-related protein Rab-10 [KO:K07903]
54190  Rabep1; rab GTPase-binding effector protein 1 [KO:K12480]
54227  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
54241  Cltc; clathrin heavy chain 1 [KO:K04646]
54258  Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175]
56084  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1 [KO:K12182]
59075  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
59076  Grk6; G protein-coupled receptor kinase 6 isoform c [KO:K08291] [EC:2.7.11.16]
59077  Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
60443  Epn2; epsin-2 isoform b [KO:K12471]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
60668  Amph; amphiphysin [KO:K12562]
619382  Acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
64310  Arf1; ADP-ribosylation factor 1 [KO:K07937]
64465  Cdc42; cell division control protein 42 homolog [KO:K04393]
64516  Vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
64633  Rab5a; ras-related protein Rab-5A [KO:K07887]
64678  Tfrc; transferrin receptor protein 1 [KO:K06503]
65046  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
65218  Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
679886  Chmp4bl1; chromatin modifying protein 4B-like 1 [KO:K12194]
680121  Haus8l2; heat shock cognate 71 kDa protein-like [KO:K03283]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
681059  Vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
682507  Wasl; actin nucleation-promoting factor WASL [KO:K23612]
684097  Snx3; sorting nexin-3 [KO:K17918]
684122  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
684800  Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
685244  Iqsec2; IQ motif and SEC7 domain-containing protein 2 isoform 2 [KO:K12495]
686590  Iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform 1 [KO:K12495]
687208  Vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
687758  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
689364  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
690516  Smurf1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
690777  Rufy2; RUN and FYVE domain-containing protein 2 [KO:K12482]
691149  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
79117  Arf5; ADP-ribosylation factor 5 [KO:K07940]
79119  Arf2; ADP-ribosylation factor 2 [KO:K07937]
79120  Arf4; ADP-ribosylation factor 4 [KO:K07939]
79121  Arf6; ADP-ribosylation factor 6 [KO:K07941]
79128  Dab2; disabled homolog 2 [KO:K12475]
79434  Rab11b; ras-related protein Rab-11B [KO:K07905]
81637  Ap2a2; AP-2 complex subunit alpha-2 [KO:K11824]
81732  Actr3; actin-related protein 3 [KO:K18584]
81760  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
81810  Tgfbr2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
81824  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
81830  Rab11a; ras-related protein Rab-11A [KO:K07904]
81918  Pard3; partitioning defective 3 homolog [KO:K04237]
81921  Sh3gl3; endophilin-A3 isoform 1 [KO:K11247]
81922  Sh3gl1; endophilin-A2 [KO:K11247]
83709  Git1; ARF GTPase-activating protein GIT1 [KO:K05737]
83800  Clta; clathrin light chain A [KO:K04644]
83805  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
84006  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
84357  Sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
84471  Snx1; sorting nexin-1 [KO:K17917]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
rno04060  Cytokine-cytokine receptor interaction
rno04070  Phosphatidylinositol signaling system
rno04130  SNARE interactions in vesicular transport
rno04142  Lysosome
rno04350  TGF-beta signaling pathway
KO pathway
ko04144   

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