KEGG   PATHWAY: rro04512
Entry
rro04512                    Pathway                                
Name
ECM-receptor interaction - Rhinopithecus roxellana (golden snub-nosed monkey)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
rro04512  ECM-receptor interaction
rro04512

Other DBs
GO: 0005201
Organism
Rhinopithecus roxellana (golden snub-nosed monkey) [GN:rro]
Gene
104653746  SV2C; synaptic vesicle glycoprotein 2C isoform X2 [KO:K06258]
104653775  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
104654307  SDC1; syndecan-1 [KO:K06257]
104654717  ITGA2B; integrin alpha-IIb [KO:K06476]
104654840  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
104654892  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
104655275  GP9; platelet glycoprotein IX isoform X1 [KO:K06263]
104655298  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104655400  ITGB5; integrin beta-5 [KO:K06588]
104656442  [KO:K06238]
104656682  GP1BB; platelet glycoprotein Ib beta chain isoform X2 [KO:K06262]
104658033  COL6A3; collagen alpha-3(VI) chain isoform X4 [KO:K06238]
104658356  CD44; CD44 antigen isoform X1 [KO:K06256]
104658643  ITGB8; integrin beta-8 [KO:K06591]
104658850  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
104659600  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
104659681  THBS1; thrombospondin-1 [KO:K16857]
104659760  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
104660445  FREM2; FRAS1-related extracellular matrix protein 2 [KO:K23380]
104660568  LAMC3; laminin subunit gamma-3 [KO:K06247]
104662513  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
104662593  ITGA11; integrin alpha-11 [KO:K06587]
104663082  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
104663240  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
104663301  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104663822  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
104663835  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104664159  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
104664167  LAMB3; laminin subunit beta-3 [KO:K06244]
104664613  SPP1; osteopontin [KO:K06250]
104665145  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
104665497  HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267]
104665530  TNN; tenascin-N isoform X1 [KO:K06252]
104665533  TNR; tenascin-R isoform X1 [KO:K06252]
104665911  MEPE; LOW QUALITY PROTEIN: matrix extracellular phosphoglycoprotein [KO:K26442]
104665913  IBSP; bone sialoprotein 2 [KO:K06253]
104666588  ITGA4; integrin alpha-4 [KO:K06483]
104666795  LAMC1; laminin subunit gamma-1 [KO:K05635]
104666798  LAMC2; laminin subunit gamma-2 [KO:K06246]
104667323  DAG1; dystroglycan [KO:K06265]
104667404  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
104667469  LAMB2; laminin subunit beta-2 [KO:K06243]
104667602  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
104667603  COL6A1; collagen alpha-1(VI) chain isoform X1 [KO:K06238]
104667754  ITGAV; integrin alpha-V isoform X2 [KO:K06487]
104668775  NPNT; nephronectin isoform X4 [KO:K06824]
104668793  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104669238  FN1; fibronectin isoform X1 [KO:K05717]
104669368  VTN; vitronectin [KO:K06251]
104669878  GP5; platelet glycoprotein V isoform X1 [KO:K06260]
104670221  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
104670562  ITGA5; integrin alpha-5 [KO:K06484]
104670606  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
104671046  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
104671965  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104671966  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104672365  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
104672477  ITGA2; integrin alpha-2 [KO:K06481]
104672775  ITGA9; integrin alpha-9 [KO:K06585]
104673225  AGRN; agrin isoform X1 [KO:K06254]
104673514  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
104673554  RELN; reelin [KO:K06249] [EC:3.4.21.-]
104673715  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
104674099  [KO:K06252]
104674711  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
104674752  GP6; platelet glycoprotein VI [KO:K06264]
104675733  [KO:K06238]
104677415  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
104677955  DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328]
104677956  DSPP; dentin sialophosphoprotein [KO:K23573]
104678039  [KO:K06240]
104678848  SDC4; syndecan-4 isoform X1 [KO:K16338]
104679090  FRAS1; LOW QUALITY PROTEIN: extracellular matrix protein FRAS1 [KO:K23379]
104679242  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
104679243  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104679259  TNC; tenascin isoform X1 [KO:K06252]
104680130  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
104680172  THBS4; thrombospondin-4 [KO:K04659]
104680202  CD36; platelet glycoprotein 4 [KO:K06259]
104680210  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
104680261  ITGA3; integrin alpha-3 [KO:K06482]
104680270  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
104680276  CHAD; chondroadherin [KO:K06248]
104680588  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
104680632  COMP; cartilage oligomeric matrix protein [KO:K04659]
104681095  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
104681299  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
104681915  THBS2; thrombospondin-2 [KO:K04659]
104682643  FREM1; FRAS1-related extracellular matrix protein 1 isoform X2 [KO:K23380]
104682783  COL1A2; collagen alpha-2(I) chain [KO:K06236]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
rro04510  Focal adhesion
KO pathway
ko04512   

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