PATHWAY: sft02020 Help
Entry Name Two-component system - Shigella flexneri NCTC1 (serotype 2a)
Description Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Shigella flexneri NCTC1 (serotype 2a) [GN:
sft ]
Gene NCTC1_00156 degP; serine endoprotease,Periplasmic serine endoprotease DegP precursor,serine endoprotease,Predicted secreted protein containing a PDZ domain,peptidase Do,PDZ domain (Also known as DHR or GLGF) [KO:K04771 ] [EC:3.4.21.107 ]
NCTC1_00161 glnD; PII uridylyl-transferase,PII uridylyl-transferase,UTP:GlnB (protein PII) uridylyltransferase,protein-P-II uridylyltransferase,GlnD PII-uridylyltransferase [KO:K00990 ] [EC:2.7.7.59 ]
NCTC1_00193 rcsF; outer membrane lipoprotein,hypothetical protein,outer membrane lipoprotein [KO:K06080 ]
NCTC1_00241 phoA; alkaline phosphatase,Alkaline phosphatase precursor,alkaline phosphatase,Alkaline phosphatase [KO:K01077 ] [EC:3.1.3.1 ]
NCTC1_00346 phoB; transcriptional regulator PhoB,Phosphate regulon transcriptional regulatory protein phoB,transcriptional regulator PhoB,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07657 ]
NCTC1_00347 phoR; phosphate regulon sensor protein,Phosphate regulon sensor protein phoR,phosphate regulon sensor protein,Predicted periplasmic ligand-binding sensor domain,phosphate regulon sensor kinase PhoR,Domain of unknown function (DUF3329) [KO:K07636 ] [EC:2.7.13.3 ]
NCTC1_00479 cheB2; LuxR family two component transcriptional regulator,Chemotaxis response regulator protein-glutamate methylesterase of group 2 operon,transcriptional regulator FimZ,Response regulator of citrate/malate metabolism,Response regulator receiver domain [KO:K07688 ]
NCTC1_00487 cusS; sensor kinase CusS,Sensor kinase CusS,sensor kinase CusS,Predicted periplasmic ligand-binding sensor domain,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07644 ] [EC:2.7.13.3 ]
NCTC1_00488 cusR; putative 2-component transcriptional regulator,Transcriptional regulatory protein CusR,DNA-binding transcriptional activator CusR,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain [KO:K07665 ]
NCTC1_00489 cusC; putative resistance protein,Cation efflux system protein CusC precursor,copper/silver efflux system outer membrane protein CusC,efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family,Outer membrane efflux protein [KO:K07796 ]
NCTC1_00490 cusF; Cation efflux system protein cusF precursor,Cation efflux system protein CusF precursor,periplasmic copper-binding protein,Uncharacterized conserved protein,Copper binding periplasmic protein CusF [KO:K07810 ]
NCTC1_00491 cusB-1; putative membrane-fusion protein,Cation efflux system protein CusB precursor,copper/silver efflux system membrane fusion protein CusB [KO:K07798 ]
NCTC1_00500 ybdE; inner membrane component for iron transport,Cation efflux system protein CusA,multidrug efflux system subunit MdtC,heavy metal efflux pump, CzcA family,AcrB/AcrD/AcrF family [KO:K07787 ]
NCTC1_00516 fepA; outer membrane receptor FepA,Enterobactin outer-membrane receptor,outer membrane receptor FepA,Outer membrane receptor for ferrienterochelin and colicins,TonB-dependent siderophore receptor,TonB dependent receptor [KO:K19611 ]
NCTC1_00557 ybdS_2; membrane protein,Citrate/succinate antiporter,transporter, divalent anion:Na+ symporter (DASS) family,Sodium:sulfate symporter transmembrane region [KO:K09477 ]
NCTC1_00558 citG; triphosphoribosyl-dephospho-CoA synthase,triphosphoribosyl-dephospho-CoA synthase,Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase),triphosphoribosyl-dephospho-CoA synthase CitG,ATP:dephospho-CoA triphosphoribosyl transferase [KO:K05966 ] [EC:2.4.2.52 ]
NCTC1_00559 citX; putative apo-citrate lyase phosphoribosyl-dephospho-CoA transferase, 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase,Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase),holo-ACP synthase CitX,Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase [KO:K05964 ] [EC:2.7.7.61 ]
NCTC1_00560 citF; Citrate lyase alpha chain,Citrate lyase alpha chain,citrate lyase, alpha subunit,Citrate lyase, alpha subunit (CitF) [KO:K01643 ] [EC:2.8.3.10 ]
NCTC1_00561 citE; citrate lyase subunit beta,Citrate lyase subunit beta,Citrate lyase beta subunit,citrate (pro-3S)-lyase, beta subunit,HpcH/HpaI aldolase/citrate lyase family [KO:K01644 ] [EC:4.1.3.34 ]
NCTC1_00562 citD; citrate lyase subunit gamma,Citrate lyase gamma chain,citrate lyase subunit gamma,Citrate lyase, gamma subunit,citrate lyase acyl carrier protein,Malonate decarboxylase delta subunit (MdcD) [KO:K01646 ]
NCTC1_00563 citC; citrate lyase synthetase,[Citrate [pro-3S]-lyase] ligase,[citrate (pro-3S)-lyase] ligase,Citrate lyase ligase C-terminal domain [KO:K01910 ] [EC:6.2.1.22 ]
NCTC1_00597 ybgT; cyd operon protein YbgT,hypothetical protein,Predicted outer membrane lipoprotein,cyd operon protein YbgT,Membrane bound YbgT-like protein [KO:K00424 ] [EC:7.1.1.7 ]
NCTC1_00598 cydB1; cytochrome d ubiquinol oxidase subunit II,Cytochrome d ubiquinol oxidase subunit 2,cytochrome d ubiquinol oxidase subunit 2,cytochrome d ubiquinol oxidase, subunit II,Cytochrome oxidase subunit II [KO:K00426 ] [EC:7.1.1.7 ]
NCTC1_00599 cydA; cytochrome d terminal oxidase, polypeptide subunit I,Cytochrome d ubiquinol oxidase subunit 1,cytochrome d terminal oxidase subunit 1,Bacterial Cytochrome Ubiquinol Oxidase [KO:K00425 ] [EC:7.1.1.7 ]
NCTC1_00633 kdpA; potassium-transporting ATPase subunit A,potassium-transporting ATPase subunit A,K+-transporting ATPase, A chain,K+-transporting ATPase, A subunit,Potassium-transporting ATPase A subunit [KO:K01546 ]
NCTC1_00634 kdpB_1; potassium-transporting ATPase subunit B,Potassium-transporting ATPase B chain,potassium-transporting ATPase subunit B,Uncharacterized protein conserved in bacteria,K+-transporting ATPase, B subunit,E1-E2 ATPase [KO:K01547 ] [EC:7.2.2.6 ]
NCTC1_00636 kdpC; potassium-transporting ATPase subunit C,potassium-transporting ATPase subunit C,K+-transporting ATPase, C subunit,K+-transporting ATPase, c chain [KO:K01548 ]
NCTC1_00637 kdpD_1; sensor protein KdpD,Sensor protein KdpD,sensor protein KdpD,Osmosensitive K+ channel His kinase sensor domain [KO:K07646 ] [EC:2.7.13.3 ]
NCTC1_00638 kdpD_2; sensor protein KdpD,Sensor protein KdpD,sensor protein KdpD,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07646 ] [EC:2.7.13.3 ]
NCTC1_00639 kdpE_1; DNA-binding transcriptional activator KdpE,KDP operon transcriptional regulatory protein KdpE,DNA-binding transcriptional activator KdpE,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07667 ]
NCTC1_00675 gltJ; glutamate/aspartate ABC transporter permease GltJ,Inner membrane amino-acid ABC transporter permease protein yecS,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10003 ]
NCTC1_00676 gltK_1; glutamate/aspartate ABC transporter permease GltK,Glutamate/aspartate transport system permease protein gltK,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10002 ]
NCTC1_00677 gltL; glutamate/aspartate ABC transporter ATP-binding protein,Arginine transport ATP-binding protein ArtM,glutamine ABC transporter ATP-binding protein,ABC-type histidine transport system, ATPase component,ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA,ABC transporter [KO:K10004 ] [EC:7.4.2.1 ]
NCTC1_00909 ybhC; putative pectinesterase,Putative acyl-CoA thioester hydrolase ybhC precursor,acyl-CoA thioesterase,Pectinesterase [KO:K01051 ] [EC:3.1.1.11 ]
NCTC1_00963 ompF; outer membrane protein F,Porin OmpF,outer membrane protein F,Outer membrane protein (porin),Gram-negative porin [KO:K09476 ]
NCTC1_00977 fimD_1; outer membrane usher FimD-like protein,Outer membrane usher protein fimD precursor,outer membrane usher protein,Fimbrial Usher protein [KO:K07347 ]
NCTC1_01011 hyaA; nickel-dependent hydrogenase, small subunit,Hydrogenase-1 small chain precursor,hydrogenase 2 small subunit,Coenzyme F420-reducing hydrogenase, gamma subunit,hydrogenase (NiFe) small subunit (hydA),NADH ubiquinone oxidoreductase, 20 Kd subunit [KO:K06282 ] [EC:1.12.99.6 ]
NCTC1_01012 hyaB; hydrogenase 1 large subunit,Hydrogenase-1 large chain,hydrogenase 1 large subunit,Coenzyme F420-reducing hydrogenase, alpha subunit,coenzyme F420 hydrogenase, subunit alpha,Nickel-dependent hydrogenase [KO:K06281 ] [EC:1.12.99.6 ]
NCTC1_01013 hyaC; hydrogenase 1 b-type cytochrome subunit,Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit,hydrogenase 1 b-type cytochrome subunit,Cytochrome b,Ni/Fe-hydrogenase, b-type cytochrome subunit,Cytochrome b(N-terminal)/b6/petB [KO:K03620 ]
NCTC1_01017 appC; cytochrome bd-II oxidase subunit I,Cytochrome bd-II oxidase subunit 1,cytochrome bd-II oxidase subunit 1,Bacterial Cytochrome Ubiquinol Oxidase [KO:K00425 ] [EC:7.1.1.7 ]
NCTC1_01018 appB; cytochrome bd-II oxidase subunit II,Cytochrome bd-II oxidase subunit 2,cytochrome bd-II oxidase subunit 2,cytochrome d ubiquinol oxidase, subunit II,Cytochrome oxidase subunit II [KO:K00426 ] [EC:7.1.1.7 ]
NCTC1_01019 yccB; membrane protein,hypothetical protein,hypothetical protein,Membrane bound YbgT-like protein [KO:K22501 ] [EC:7.1.1.7 ]
NCTC1_01021 etk1; cryptic autophosphorylating protein tyrosine kinase Etk,Tyrosine-protein kinase etk,cryptic autophosphorylating protein tyrosine kinase Etk,Capsular polysaccharide biosynthesis protein,exopolysaccharide transport protein family,Chain length determinant protein [KO:K16692 ] [EC:2.7.10.3 ]
NCTC1_01022 etp; Low molecular weight protein-tyrosine-phosphatase etp,Low molecular weight protein-tyrosine-phosphatase etp,phosphotyrosine-protein phosphatase,Protein-tyrosine-phosphatase,arsenate reductase (thioredoxin),Low molecular weight phosphotyrosine protein phosphatase [KO:K25307 ]
NCTC1_01023 yccZ; outer membrane lipoprotein, group 4 capsule (G4C) polysaccharide,Polysialic acid transport protein kpsD precursor,polysaccharide export protein Wza,polysaccharide export protein EpsE,Polysaccharide biosynthesis/export protein [KO:K01991 ]
NCTC1_01031 torS_1; hybrid sensory histidine kinase TorS,Sensor protein torS,hybrid sensory histidine kinase TorS,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07647 ] [EC:2.7.13.3 ]
NCTC1_01034 torR; DNA-binding transcriptional regulator TorR,TorCAD operon transcriptional regulatory protein torR,DNA-binding transcriptional regulator TorR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07772 ]
NCTC1_01035 torC; trimethylamine N-oxide reductase, cytochrome c-type subunit,Cytochrome c-type protein TorC,trimethylamine N-oxide reductase cytochrome c-type subunit,trimethylamine-N-oxide reductase c-type cytochrome TorC,NapC/NirT cytochrome c family, N-terminal region [KO:K03532 ]
NCTC1_01036 torA_1; trimethylamine N-oxide reductase subunit,Trimethylamine-N-oxide reductase 1 precursor,trimethylamine N-oxide reductase I catalytic subunit,Uncharacterized anaerobic dehydrogenase,trimethylamine-N-oxide reductase TorA,Molybdopterin oxidoreductase [KO:K07811 ] [EC:1.7.2.3 ]
NCTC1_01040 torD_2; chaperone protein TorD,Chaperone protein TorD,chaperone protein TorD,Uncharacterized component of anaerobic dehydrogenases,DMSO reductase family type II enzyme chaperone,Nitrate reductase delta subunit [KO:K03533 ]
NCTC1_01125 flgM; anti-sigma-28 factor FlgM,Anti-sigma-28 factor,anti-sigma28 factor FlgM,flagellar biosynthesis anti-sigma factor FlgM,Anti-sigma-28 factor, FlgM [KO:K02398 ]
NCTC1_01206 phoQ; sensor protein PhoQ,Sensor protein PhoQ,sensor protein PhoQ,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,PhoQ Sensor [KO:K07637 ] [EC:2.7.13.3 ]
NCTC1_01207 phoP; DNA-binding transcriptional regulator PhoP,Transcriptional regulatory protein phoP,DNA-binding transcriptional regulator PhoP,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07660 ]
NCTC1_01292 narL; transcriptional regulator NarL,Nitrate/nitrite response regulator protein narL,transcriptional regulator NarL,Signal transduction histidine kinase, nitrate/nitrite-specific,sporulation transcription factor Spo0A,Response regulator receiver domain [KO:K07684 ]
NCTC1_01293 narX; nitrate/nitrite sensor protein NarX,Nitrate/nitrite sensor protein narX,nitrate/nitrite sensor protein NarX,Signal transduction histidine kinase, nitrate/nitrite-specific,Histidine kinase [KO:K07673 ] [EC:2.7.13.3 ]
NCTC1_01296 narG; nitrate reductase 1 subunit alpha,Respiratory nitrate reductase 1 alpha chain,anaerobic dimethyl sulfoxide reductase subunit A,Uncharacterized anaerobic dehydrogenase,nitrate reductase, alpha subunit,Molybdopterin oxidoreductase [KO:K00370 ] [EC:1.7.5.1 1.7.99.-]
NCTC1_01297 narH; nitrate reductase 1 subunit beta,Respiratory nitrate reductase 1 beta chain,tetrathionate reductase subunit B,Uncharacterized Fe-S center protein,nitrate reductase, beta subunit,4Fe-4S dicluster domain [KO:K00371 ] [EC:1.7.5.1 1.7.99.-]
NCTC1_01298 narJ; nitrate reductase molybdenum cofactor assembly chaperone 1,Redox enzyme maturation protein NarJ,nitrate reductase 2 subunit delta,nitrate reductase molybdenum cofactor assembly chaperone,Nitrate reductase delta subunit [KO:K00373 ]
NCTC1_01299 narI; respiratory nitrate reductase 1, gamma subunit,Respiratory nitrate reductase 1 gamma chain,Nitrate reductase gamma subunit,respiratory nitrate reductase, gamma subunit,Nitrate reductase gamma subunit [KO:K00374 ] [EC:1.7.5.1 1.7.99.-]
NCTC1_01659 safA; two-protein-system connector protein SafA,Sensor associating factor A [KO:K23236 ]
NCTC1_01767 rstA; Response transcriptional regulatory protein,Transcriptional regulatory protein RstA,DNA-binding transcriptional regulator RstA,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Transcriptional regulatory protein, C terminal [KO:K07661 ]
NCTC1_01769 rstB; sensor protein RstB,Sensor protein RstB,sensor protein RstB,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07639 ] [EC:2.7.13.3 ]
NCTC1_01885 ddpX; Peptidase M15D, vanX D-ala-D-ala dipeptidase,D-alanyl-D-alanine dipeptidase,D-alanyl-D-alanine dipeptidase,D-ala-D-ala dipeptidase [KO:K08641 ] [EC:3.4.13.22 ]
NCTC1_01891 sfcA; malate dehydrogenase,NAD-dependent malic enzyme,malate dehydrogenase,Malic enzyme, NAD binding domain [KO:K00027 ] [EC:1.1.1.38 ]
NCTC1_01894 fdnI; formate dehydrogenase-N subunit gamma,Formate dehydrogenase-N subunit gamma,formate dehydrogenase-N subunit gamma,formate dehydrogenase, gamma subunit,Cytochrome b(N-terminal)/b6/petB [KO:K08350 ]
NCTC1_01895 fdnH; formate dehydrogenase, nitrate-inducible, iron-sulfur subunit,Formate dehydrogenase-N subunit beta,hydrogenase 2 protein HybA,Uncharacterized Fe-S center protein,formate dehydrogenase, beta subunit,Formate dehydrogenase N, transmembrane [KO:K08349 ]
NCTC1_01905 narZ_2; cryptic nitrate reductase 2 subunit alpha,Respiratory nitrate reductase 2 alpha chain,thiosulfate reductase PhsA,Uncharacterized anaerobic dehydrogenase,nitrate reductase, alpha subunit,Molybdopterin oxidoreductase [KO:K00370 ] [EC:1.7.5.1 1.7.99.-]
NCTC1_01906 narY; Nitrate reductase 1, beta subunit,Respiratory nitrate reductase 2 beta chain,tetrathionate reductase subunit B,Uncharacterized Fe-S center protein,nitrate reductase, beta subunit,4Fe-4S dicluster domain [KO:K00371 ] [EC:1.7.5.1 1.7.99.-]
NCTC1_01920 trg; Methyl-accepting chemotaxis protein III, ribose sensor receptor,Ribose and galactose chemoreceptor protein,methyl-accepting chemotaxis protein II,Predicted periplasmic ligand-binding sensor domain,Methyl-accepting chemotaxis protein (MCP) signaling domain [KO:K05876 ]
NCTC1_02097 cheY; chemotaxis regulatory protein CheY,Chemotaxis protein CheY,chemotaxis regulatory protein CheY,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K03413 ]
NCTC1_02098 cheB; chemotaxis-specific methylesterase,Chemotaxis response regulator protein-glutamate methylesterase,chemotaxis-specific methylesterase,Response regulator of citrate/malate metabolism,sporulation transcription factor Spo0A,CheB methylesterase [KO:K03412 ] [EC:3.1.1.61 3.5.1.44 ]
NCTC1_02099 cheR; chemotaxis methyltransferase CheR,Chemotaxis protein methyltransferase,chemotaxis methyltransferase CheR,Response regulator,CheR methyltransferase, SAM binding domain [KO:K00575 ] [EC:2.1.1.80 ]
NCTC1_02100 tap; methyl-accepting protein IV,Dipeptide chemoreceptor protein,methyl-accepting protein IV,Predicted periplasmic ligand-binding sensor domain,Methyl-accepting chemotaxis protein (MCP) signaling domain [KO:K05877 ]
NCTC1_02101 tar; Methyl-accepting chemotaxis protein II, aspartate sensor receptor,Aspartate chemoreceptor protein,methyl-accepting chemotaxis protein II,Predicted periplasmic ligand-binding sensor domain,Methyl-accepting chemotaxis protein (MCP) signaling domain [KO:K05875 ]
NCTC1_02103 cheW; purine-binding chemotaxis protein,Chemotaxis protein CheW,purine-binding chemotaxis protein,CheW-like domain [KO:K03408 ]
NCTC1_02104 cheA; chemotaxis protein CheA,Chemotaxis protein CheA,chemotaxis protein CheA,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,TMAO reductase sytem sensor TorS,CheW-like domain [KO:K03407 ] [EC:2.7.13.3 ]
NCTC1_02106 motA; flagellar motor protein MotA,Chemotaxis protein MotA,flagellar motor protein MotA,flagellar motor stator protein MotA [KO:K02556 ]
NCTC1_02107 flhC; Flagellar transcriptional activator flhC,Flagellar transcriptional regulator FlhC,transcriptional activator FlhC,Flagellar transcriptional activator (FlhC) [KO:K02402 ]
NCTC1_02108 flhD; Transcriptional activator flhD,Flagellar transcriptional regulator FlhD,transcriptional activator FlhD,Flagellar transcriptional activator (FlhD) [KO:K02403 ]
NCTC1_02128 uvrY; response regulator,Response regulator uvrY,response regulator,Response regulator,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07689 ]
NCTC1_02130 sdiA; DNA-binding transcriptional activator SdiA,Regulatory protein SdiA,DNA-binding transcriptional activator SdiA,transcriptional regulator EpsA,Autoinducer binding domain [KO:K07782 ]
NCTC1_02136 fliA_1; flagellar biosynthesis sigma factor,Sigma-F factor,flagellar biosynthesis sigma factor,RNA polymerase sigma factor, FliA/WhiG family,Sigma-70 region 3 [KO:K02405 ]
NCTC1_02138 fliC; Flagellin,Flagellin,flagellin,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,flagellar hook-associated protein 3,Bacterial flagellin N-terminal helical region [KO:K02406 ]
NCTC1_02170 rcsA; positive regulator for ctr capsule biosynthesis, positive transcription factor,Colanic acid capsular biosynthesis activation protein A,colanic acid capsular biosynthesis activation protein A,Bacterial regulatory proteins, luxR family [KO:K07781 ]
NCTC1_02186 ompD_3; outer membrane pore protein,Outer membrane porin protein OmpD precursor,outer membrane phosphoporin protein E,Outer membrane protein (porin),Gram-negative porin [KO:K09476 ]
NCTC1_02333 wzc; tyrosine kinase,Tyrosine-protein kinase wzc,tyrosine kinase,Capsular polysaccharide biosynthesis protein,exopolysaccharide transport protein family,Chain length determinant protein [KO:K16692 ] [EC:2.7.10.3 ]
NCTC1_02334 wzb; tyrosine phosphatase,Low molecular weight protein-tyrosine-phosphatase wzb,tyrosine phosphatase,Protein-tyrosine-phosphatase,arsenate reductase (thioredoxin),Low molecular weight phosphotyrosine protein phosphatase [KO:K25307 ]
NCTC1_02354 mdtA; multidrug efflux system subunit MdtA,Efflux pump periplasmic linker BepD precursor,multidrug efflux system subunit MdtA,efflux transporter, RND family, MFP subunit,HlyD family secretion protein [KO:K07799 ]
NCTC1_02355 mdtB_1; multidrug efflux system subunit MdtB,Multidrug transporter MdtC,multidrug efflux system subunit MdtB,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family [KO:K07788 ]
NCTC1_02357 mdtC; multidrug efflux system subunit MdtC,Multidrug transporter MdtC,multidrug efflux system subunit MdtC,Predicted exporter,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family [KO:K07789 ]
NCTC1_02358 mdtD; multidrug efflux system protein MdtE,Putative multidrug resistance protein MdtD,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily [KO:K18326 ]
NCTC1_02359 baeS; signal transduction histidine-protein kinase BaeS,Signal transduction histidine-protein kinase BaeS,signal transduction histidine-protein kinase BaeS,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07642 ] [EC:2.7.13.3 ]
NCTC1_02360 baeR; DNA-binding transcriptional regulator BaeR,Transcriptional regulatory protein BaeR,DNA-binding transcriptional regulator BaeR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07664 ]
NCTC1_02388 yehB; outer membrane protein,Heat shock protein E,fimbrial outer membrane usher protein,Fimbrial Usher protein [KO:K07347 ]
NCTC1_02415 yehT; two-component response-regulatory protein YehT,Probable transcriptional regulatory protein YehT,putative two-component response-regulatory protein YehT,Response regulator of the LytR/AlgR family,sporulation transcription factor Spo0A,Response regulator receiver domain [KO:K27883 ]
NCTC1_02416 yehU; sensor histidine kinase,Probable sensor-like histidine kinase YehU,Predicted signal transduction protein with a C-terminal ATPase domain,5TMR of 5TMR-LYT [KO:K27882 ]
NCTC1_02502 narP; transcriptional regulator NarP,Nitrate/nitrite response regulator protein narL,transcriptional regulator NarP,Response regulator,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07685 ]
NCTC1_02527 ompC; outer membrane porin protein C,Porin OmpC,outer membrane porin protein C,Outer membrane protein (porin),Gram-negative porin [KO:K09475 ]
NCTC1_02529 yojN_1; phosphotransfer intermediate protein in two-component regulatory system with RcsBC,Sensor-like histidine kinase RcsD,phosphotransfer intermediate protein in two-component regulatory system with RcsBC,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07676 ] [EC:2.7.13.3 ]
NCTC1_02531 rcsB; transcriptional regulator RcsB,Capsular synthesis regulator component B,transcriptional regulator RcsB,Response regulator,nitrogen regulation protein NR(I),Response regulator receiver domain [KO:K07687 ]
NCTC1_02532 rcsC; hybrid sensory kinase in two-component regulatory system with RcsB and YojN,Sensor kinase protein RcsC,hybrid sensory kinase in two-component regulatory system with RcsB and YojN,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,RcsC Alpha-Beta-Loop (ABL) [KO:K07677 ] [EC:2.7.13.3 ]
NCTC1_02565 arnB; DegT/DnrJ/EryC1/StrS aminotransferase, UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase,Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis,UDP-4-keto-6-deoxy-N-acetylglucosamine 4-aminotransferase,DegT/DnrJ/EryC1/StrS aminotransferase family [KO:K07806 ] [EC:2.6.1.87 ]
NCTC1_02670 emrY; multidrug resistance protein Y,Multidrug resistance protein B,putative transporter,Arabinose efflux permease,drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family,Major Facilitator Superfamily [KO:K07786 ]
NCTC1_02671 emrK; drug resistance MFS transporter, membrane fusion protein (MFP) subunit EmrK,Inner membrane protein yibH,multidrug efflux system protein EmrA,efflux pump membrane protein,HlyD family secretion protein [KO:K07797 ]
NCTC1_02672 evgA; DNA-binding transcriptional activator EvgA,Positive transcription regulator evgA,DNA-binding transcriptional activator EvgA,Response regulator,sporulation transcription factor Spo0A,Response regulator receiver domain [KO:K07690 ]
NCTC1_02673 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA,Sensor protein evgS precursor,hybrid sensory histidine kinase in two-component regulatory system with EvgA,Response regulator containing a CheY-like receiver domain and a GGDEF domain,TMAO reductase sytem sensor TorS,Bacterial extracellular solute-binding proteins, family 3 [KO:K07679 ] [EC:2.7.13.3 ]
NCTC1_02683 ypdA; YpdA, sensory kinase in two-component system with YpdB,Inner membrane protein ypdA,Predicted signal transduction protein with a C-terminal ATPase domain,phosphate regulon sensor kinase PhoR,Histidine kinase [KO:K27884 ]
NCTC1_02684 mrkE; response regulator,hypothetical protein,two-component response regulator,Response regulator of the LytR/AlgR family,sporulation transcription factor Spo0A,LytTr DNA-binding domain [KO:K27885 ]
NCTC1_02761 narQ_2; nitrate/nitrite sensor protein NarQ,Nitrate/nitrite sensor protein narX,nitrate/nitrite sensor protein NarQ,Signal transduction histidine kinase, nitrate/nitrite-specific,Histidine kinase [KO:K07674 ] [EC:2.7.13.3 ]
NCTC1_02762 acrD; aminoglycoside/multidrug efflux system,Acriflavine resistance protein B,aminoglycoside/multidrug efflux system,RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family,AcrB/AcrD/AcrF family [KO:K18324 ]
NCTC1_02859 glnB; nitrogen regulatory protein P-II 1,Nitrogen regulatory protein P-II 1,nitrogen regulatory protein P-II 1,Nitrogen regulatory protein P-II [KO:K04751 ]
NCTC1_02860 qseF_2; sigma-54 dependent response regulator,Quorum-sensing regulator protein F,response regulator GlrR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain [KO:K07715 ]
NCTC1_02862 yfhK; 2-component sensor protein,Sensor histidine kinase QseE,sensory histidine kinase CreC,Predicted periplasmic ligand-binding sensor domain,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07711 ] [EC:2.7.13.3 ]
NCTC1_02994 csrA; carbon storage regulator,Carbon storage regulator,carbon storage regulator,carbon storage regulator,Global regulator protein family [KO:K03563 ]
NCTC1_03078 barA; hybrid sensory histidine kinase BarA,Signal transduction histidine-protein kinase BarA,hybrid sensory histidine kinase BarA,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Uncharacterized signal transduction histidine kinase domain (DUF2222) [KO:K07678 ] [EC:2.7.13.3 ]
NCTC1_03142 thlA; acetyl-CoA acetyltransferase,Acetyl-CoA acetyltransferase,acetyl-CoA acetyltransferase,Transcription-associated recombination protein,acetyl-CoA C-acetyltransferase,Thiolase, N-terminal domain [KO:K00626 ] [EC:2.3.1.9 ]
NCTC1_03239 siaP_2; putative dicarboxylate-binding periplasmic protein,Neu5Ac-binding protein,TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component,TRAP transporter solute receptor, DctP family,Bacterial extracellular solute-binding protein, family 7 [KO:K11688 ]
NCTC1_03240 yiaM_1; putative small integral C4-dicarboxylate membrane transport protein DctQ,2,3-diketo-L-gulonate TRAP transporter small permease protein yiaM,2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM,TRAP-type C4-dicarboxylate transport system, small permease component,Tripartite ATP-independent periplasmic transporters, DctQ component [KO:K11689 ]
NCTC1_03243 siaT_1; integral membrane protein,Neu5Ac permease,L-dehydroascorbate transporter large permease subunit,TRAP-type C4-dicarboxylate transport system, small permease component,TRAP transporter, DctM subunit,DctM-like transporters [KO:K11690 ]
NCTC1_03295 hybC; hydrogenase 2 large subunit,Hydrogenase-2 large chain precursor,hydrogenase 2 large subunit,Coenzyme F420-reducing hydrogenase, alpha subunit,coenzyme F420 hydrogenase, subunit alpha,Nickel-dependent hydrogenase [KO:K06281 ] [EC:1.12.99.6 ]
NCTC1_03298 hyb0; hydrogenase 2 small subunit,Hydrogenase-2 small chain precursor,hydrogenase 2 small subunit,Coenzyme F420-reducing hydrogenase, gamma subunit,hydrogenase (NiFe) small subunit (hydA),NADH ubiquinone oxidoreductase, 20 Kd subunit [KO:K06282 ] [EC:1.12.99.6 ]
NCTC1_03321 qseB_1; DNA-binding transcriptional regulator QseB,Transcriptional activator protein CopR,DNA-binding transcriptional regulator QseB,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain [KO:K07666 ]
NCTC1_03323 qseC; putative Sensor protein,Sensor protein qseC,sensor protein QseC,Signal transduction histidine kinase regulating C4-dicarboxylate transport system,heavy metal sensor kinase,His Kinase A (phospho-acceptor) domain [KO:K07645 ] [EC:2.7.13.3 ]
NCTC1_03331 tolC; outer membrane channel protein,Outer membrane protein tolC precursor,outer membrane channel protein,type I secretion outer membrane protein, TolC family,Outer membrane efflux protein [KO:K12340 ]
NCTC1_03373 aer_2; aerotaxis receptor,Aerotaxis receptor,methyl-accepting chemotaxis protein II,nitrogen fixation negative regulator NifL,PAS fold [KO:K03776 ]
NCTC1_03404 mzrA; EnvZ/OmpR regulon moderator,Modulator protein MzrA,EnvZ/OmpR regulon moderator [KO:K25864 ]
NCTC1_03451 yraI; putative chaperone,Chaperone protein fimC precursor,long polar fimbrial chaperone LpfB,Gram-negative pili assembly chaperone, N-terminal domain [KO:K07346 ]
NCTC1_03452 fimD_2; outer membrane protein,Outer membrane usher protein fimD precursor,long polar fimbrial outer membrane usher protein LpfC,Fimbrial Usher protein [KO:K07347 ]
NCTC1_03518 rpoN; RNA polymerase factor sigma-54,RNA polymerase factor sigma-54,DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog,RNA polymerase sigma-54 factor,Sigma-54 factor, core binding domain [KO:K03092 ]
NCTC1_03527 arcB; aerobic respiration control sensor protein ArcB,Aerobic respiration control sensor protein ArcB,aerobic respiration control sensor protein ArcB,Uncharacterized domain of BarA-like signal transduction histidine kinases,TMAO reductase sytem sensor TorS,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07648 ] [EC:2.7.13.3 ]
NCTC1_03656 crp; cAMP-regulatory protein,cAMP regulatory protein,DNA-binding transcriptional dual regulator Crp,Predicted signal-transduction protein containing cAMP-binding and CBS domains,global nitrogen regulator NtcA,Cyclic nucleotide-binding domain [KO:K10914 ]
NCTC1_03703 envZ; osmolarity sensor protein,Osmolarity sensor protein EnvZ,osmolarity sensor protein,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07638 ] [EC:2.7.13.3 ]
NCTC1_03704 ompR; osmolarity response regulator,Transcriptional regulatory protein OmpR,osmolarity response regulator,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07659 ]
NCTC1_03798 caf1A_3; putative fimbrial protein remnant,F1 capsule-anchoring protein precursor,pilin outer membrane usher protein SafC,Fimbrial Usher protein [KO:K07347 ]
NCTC1_03842 dctA; C4-dicarboxylate transporter DctA,Aerobic C4-dicarboxylate transport protein,C4-dicarboxylate transporter DctA,Sodium:dicarboxylate symporter family [KO:K11103 ]
NCTC1_03872 yhjX; putative permeases of the major facilitator superfamily,Inner membrane protein yhjX,putative sialic acid transporter,Arabinose efflux permease,oxalate/formate antiporter family transporter,Major Facilitator Superfamily [KO:K08177 ]
NCTC1_03917 yiaM_2; 2,3-diketo-L-gulonate TRAP transporter small permease YiaM,2,3-diketo-L-gulonate TRAP transporter small permease protein yiaM,2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM,TRAP-type C4-dicarboxylate transport system, small permease component,Tripartite ATP-independent periplasmic transporters, DctQ component [KO:K11689 ]
NCTC1_03918 siaT_2; L-dehydroascorbate transporter large permease,Neu5Ac permease,L-dehydroascorbate transporter large permease subunit,TRAP-type C4-dicarboxylate transport system, small permease component,TRAP transporter, DctM subunit,DctM-like transporters [KO:K11690 ]
NCTC1_04020 fimD_4; putative long polar fimbriae,Outer membrane usher protein fimD precursor,outer membrane usher protein,Fimbrial Usher protein [KO:K07347 ]
NCTC1_04023 pstS; phosphate ABC transporter substrate-binding protein,Phosphate-binding protein pstS precursor,phosphate ABC transporter periplasmic substrate-binding protein PstS,phosphate ABC transporter, phosphate-binding protein PstS,PBP superfamily domain [KO:K02040 ]
NCTC1_04056 dnaA; chromosomal replication initiation protein,Chromosomal replication initiator protein DnaA,chromosomal replication initiation protein,DNA replication protein,chromosomal replication initiator protein DnaA,Bacterial dnaA protein [KO:K02313 ]
NCTC1_04094 uhpA; DNA-binding transcriptional activator UhpA,Transcriptional regulatory protein uhpA,DNA-binding transcriptional activator UhpA,Response regulator,nitrogen regulation protein NR(I),Bacterial regulatory proteins, luxR family [KO:K07686 ]
NCTC1_04095 uhpB; sensory histidine kinase UhpB,Sensor protein degS,sensory histidine kinase UhpB,Signal transduction histidine kinase,MASE1 [KO:K07675 ] [EC:2.7.13.3 ]
NCTC1_04096 uhpC; regulatory protein UhpC,Regulatory protein uhpC,regulatory protein UhpC,Arabinose efflux permease,phosphoglycerate transporter family protein,Major Facilitator Superfamily [KO:K07783 ]
NCTC1_04097 uhpT; sugar phosphate antiporter,Hexose phosphate transport protein,sugar phosphate antiporter,phosphoglycerate transporter family protein,Major Facilitator Superfamily [KO:K07784 ]
NCTC1_04109 lpfB; long polar fimbrial operon protein LpfB,Chaperone protein focC precursor,fimbrial chaperone protein,Gram-negative pili assembly chaperone, N-terminal domain [KO:K07346 ]
NCTC1_04172 wecB; UDP-N-acetyl glucosamine-2-epimerase,UDP-N-acetylglucosamine 2-epimerase,UDP-N-acetylglucosamine 2-epimerase,UDP-N-acetylglucosamine 2-epimerase [KO:K01791 ] [EC:5.1.3.14 ]
NCTC1_04173 wecC; UDP-N-acetyl-D-mannosamine dehydrogenase,UDP-glucose 6-dehydrogenase ywqF,UDP-N-acetyl-D-mannosamine dehydrogenase,nucleotide sugar dehydrogenase,UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain [KO:K02472 ] [EC:1.1.1.336 ]
NCTC1_04264 glnG; nitrogen regulation protein NR(I),Nitrogen regulation protein NR(I),nitrogen regulation protein NR(I),Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain [KO:K07712 ]
NCTC1_04265 glnL; nitrogen regulation protein NR(II),Nitrogen regulation protein NR(II),nitrogen regulation protein NR(II),Signal transduction histidine kinase, nitrogen specific,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07708 ] [EC:2.7.13.3 ]
NCTC1_04266 glnA; glutamine synthetase,Glutamine synthetase,glutamine synthetase,Predicted metal-dependent hydrolase of the TIM-barrel fold,glutamine synthetase, type I,Glutamine synthetase, catalytic domain [KO:K01915 ] [EC:6.3.1.2 ]
NCTC1_04319 cpxA; two-component sensor protein,Sensor protein CpxA,two-component sensor protein,Predicted periplasmic ligand-binding sensor domain,heavy metal sensor kinase,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07640 ] [EC:2.7.13.3 ]
NCTC1_04320 cpxR; DNA-binding transcriptional regulator CpxR,Transcriptional regulatory protein walR,DNA-binding transcriptional regulator CpxR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07662 ]
NCTC1_04421 zraP; zinc resistance protein,Zinc resistance-associated protein precursor,zinc resistance protein,P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [KO:K07803 ]
NCTC1_04423 zraS; sensor protein ZraS,Sensor protein ZraS,sensor protein ZraS,Signal transduction histidine kinase, nitrogen specific,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07709 ] [EC:2.7.13.3 ]
NCTC1_04424 zraR; transcriptional regulator ZraR,Transcriptional regulatory protein ZraR,transcriptional regulatory protein ZraR,Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains,nitrogen regulation protein NR(I),Sigma-54 interaction domain [KO:K07713 ]
NCTC1_04455 yjdH; sensory histidine kinase DcuS,Sensor histidine kinase DcuS,sensory histidine kinase DcuS,Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07701 ] [EC:2.7.13.3 ]
NCTC1_04456 yjdG; DNA-binding transcriptional activator DcuR,Transcriptional regulatory protein dcuR,DNA-binding transcriptional activator DcuR,Response regulator of citrate/malate metabolism,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07703 ]
NCTC1_04457 dcuB; anaerobic C4-dicarboxylate transporter,Anaerobic C4-dicarboxylate transporter DcuB,anaerobic C4-dicarboxylate transporter,Thiol:disulfide interchange protein,transporter, anaerobic C4-dicarboxylate uptake (Dcu) family,Anaerobic c4-dicarboxylate membrane transporter [KO:K07792 ]
NCTC1_04467 basR; DNA-binding transcriptional regulator BasR,Transcriptional regulatory protein BasR,DNA-binding transcriptional regulator BasR,Response regulator of citrate/malate metabolism,heavy metal response regulator,Response regulator receiver domain [KO:K07771 ]
NCTC1_04569 fimD_5; Outer membrane usher protein fimD,Outer membrane usher protein fimD precursor,outer membrane usher protein,Fimbrial Usher protein [KO:K07347 ]
NCTC1_04572 fimC; periplasmic chaperone,Chaperone protein fimC precursor,fimbrial chaperone protein FimC,Gram-negative pili assembly chaperone, N-terminal domain [KO:K07346 ]
NCTC1_04677 ampC; Beta-lactamase; penicillin resistance,Beta-lactamase precursor,beta-lactamase/D-alanine carboxypeptidase,Uncharacterized protein conserved in bacteria,Beta-lactamase [KO:K01467 ] [EC:3.5.2.6 ]
NCTC1_04678 frdD; fumarate reductase subunit D,Fumarate reductase 13 kDa hydrophobic protein,fumarate reductase subunit D,Fumarate reductase subunit D [KO:K00247 ]
NCTC1_04679 frdC; fumarate reductase subunit C,Fumarate reductase 15 kDa hydrophobic protein,fumarate reductase subunit C,Fumarate reductase subunit C,Fumarate reductase subunit C [KO:K00246 ]
NCTC1_04680 frdB; fumarate reductase iron-sulfur subunit,Fumarate reductase iron-sulfur subunit,fumarate reductase iron-sulfur subunit,Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit,succinate dehydrogenase and fumarate reductase iron-sulfur protein [KO:K00245 ] [EC:1.3.5.1 ]
NCTC1_04681 frdA; fumarate reductase flavoprotein subunit,Fumarate reductase flavoprotein subunit,fumarate reductase flavoprotein subunit,Aspartate oxidase,fumarate reductase, flavoprotein subunit,FAD binding domain [KO:K00244 ] [EC:1.3.5.1 ]
NCTC1_04748 yjiY; carbon starvation family protein,Inner membrane protein YjiY,carbon starvation protein A,Carbon starvation protein, predicted membrane protein,Carbon starvation protein CstA [KO:K23676 ]
NCTC1_04762 tsr; Methyl-accepting chemotaxis protein I, serine sensor receptor,Serine chemoreceptor protein,methyl-accepting chemotaxis protein I,Predicted periplasmic ligand-binding sensor domain,TMAO reductase sytem sensor TorS,Methyl-accepting chemotaxis protein (MCP) signaling domain [KO:K05874 ]
NCTC1_04811 creB; DNA-binding response regulator CreB,Transcriptional regulatory protein CreB,DNA-binding response regulator CreB,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07663 ]
NCTC1_04812 creC; sensory histidine kinase CreC,Sensor protein CreC,sensory histidine kinase CreC,Uncharacterized protein conserved in bacteria,phosphate regulon sensor kinase PhoR,Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase [KO:K07641 ] [EC:2.7.13.3 ]
NCTC1_04814 arcA; two-component response regulator,Dye resistance protein,two-component response regulator,Response regulator containing a CheY-like receiver domain and an HD-GYP domain,phosphate regulon transcriptional regulatory protein PhoB,Response regulator receiver domain [KO:K07773 ]
Compound C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C11842 N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849 3-Hydroxy-palmitic acid methyl ester
C16665 12-Methyltetradecanoic acid
C18206 cis-11-Methyl-2-dodecenoic acid
Reference Authors Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
Title Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
Journal Reference Authors Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
Title Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
Journal Reference Authors Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
Title Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
Journal Reference Authors Cai SJ, Inouye M.
Title EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
Journal Reference Authors Batchelor E, Walthers D, Kenney LJ, Goulian M.
Title The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
Journal Reference Authors Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
Title The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
Journal Reference Authors Hagiwara D, Yamashino T, Mizuno T.
Title A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
Journal Reference Authors Munson GP, Lam DL, Outten FW, O'Halloran TV.
Title Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
Journal Reference Authors Sperandio V, Torres AG, Kaper JB.
Title Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
Journal Reference Authors Epstein W.
Title The roles and regulation of potassium in bacteria.
Journal Reference Authors Ansaldi M, Simon G, Lepelletier M, Mejean V.
Title The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
Journal Reference Authors Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
Title Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
Journal Reference Authors Widenhorn KA, Somers JM, Kay WW.
Title Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
Journal Reference Authors Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
Title A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
Journal Reference Authors Zhang X, Hulett FM.
Title ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
Journal Reference Authors Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
Title A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
Journal Reference Authors He H, Zahrt TC.
Title Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
Journal Reference Authors Hutchings MI
Title Unusual two-component signal transduction pathways in the actinobacteria.
Journal Reference Authors Kramer R
Title Osmosensing and osmosignaling in Corynebacterium glutamicum.
Journal Reference Authors Eraso JM, Kaplan S.
Title Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
Journal Reference Authors Haydel SE, Dunlap NE, Benjamin WH Jr.
Title In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
Journal Reference Authors Quisel JD, Burkholder WF, Grossman AD.
Title In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
Journal Reference Authors Kaspar S, Bott M.
Title The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
Journal Reference Authors Janausch IG, Garcia-Moreno I, Unden G.
Title Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
Journal Reference Authors Brunskill EW, Bayles KW.
Title Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
Journal Reference Authors Fujimoto DF, Brunskill EW, Bayles KW.
Title Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
Journal Reference Authors Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
Title High genetic variability of the agr locus in Staphylococcus species.
Journal Reference Authors Rabin RS, Stewart V.
Title Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
Journal Reference Authors Chiang RC, Cavicchioli R, Gunsalus RP.
Title 'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
Journal Reference Authors Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
Title Cooperativity in signal transfer through the Uhp system of Escherichia coli.
Journal Reference Authors Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
Title Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
Journal Reference Authors Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
Title Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
Journal Reference Authors Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
Title Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
Journal Reference Authors Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
Title Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
Journal Reference Authors Ansaldi M, Dubnau D.
Title Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
Journal Reference Authors Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
Title Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
Journal Reference Authors Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
Title Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
Journal Reference Authors Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
Title Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
Journal Reference Authors Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
Title DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
Journal Reference Authors Fedtke I, Kamps A, Krismer B, Gotz F.
Title The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
Journal Reference Authors Shiau SP, Chen P, Reitzer LJ.
Title Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
Journal Reference Authors Leonhartsberger S, Huber A, Lottspeich F, Bock A.
Title The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
Journal Reference Authors Lioliou EE, Kyriakidis DA.
Title The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
Journal Reference Authors Yamamoto K, Ishihama A
Title Transcriptional response of Escherichia coli to external copper.
Journal Reference Authors Ashby MK, Mullineaux CW
Title Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
Journal Reference Authors Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
Title A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
Title The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
Journal Reference Authors Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
Title Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
Journal Reference Authors Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
Title Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
Journal Reference Authors Yeh KC, Wu SH, Murphy JT, Lagarias JC
Title A cyanobacterial phytochrome two-component light sensory system.
Journal Reference Authors Niu S, Jiang SQ, Hong J
Title Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
Journal Reference Authors Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
Title A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
Journal Reference Authors Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
Title C4-dicarboxylate carriers and sensors in bacteria.
Journal Reference Authors Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
Title C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
Journal Reference Authors Novick RP, Jiang D
Title The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
Journal Reference Authors Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
Title The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
Journal Reference Authors Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
Title Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
Journal Reference Authors Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
Title Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
Journal Reference Authors Yoshihara S, Ikeuchi M.
Title Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
Title A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
Journal Reference Authors Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
Title A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
Journal Reference Authors Mascher T, Zimmer SL, Smith TA, Helmann JD
Title Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
Journal Reference Authors Hyyrylainen HL, Sarvas M, Kontinen VP
Title Transcriptome analysis of the secretion stress response of Bacillus subtilis.
Journal Reference Authors Serizawa M, Sekiguchi J
Title The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
Journal Reference Authors Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
Title The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Journal Reference Authors Ogura M, Tsukahara K, Hayashi K, Tanaka T
Title The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Journal Reference Authors Yamamoto H, Murata M, Sekiguchi J
Title The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
Journal Reference Authors Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
Title Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
Journal Reference Authors Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
Title The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
Journal Reference Authors Tanaka K, Kobayashi K, Ogasawara N
Title The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
Journal Reference Authors Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
Title Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
Journal Reference Authors Hamblin MJ, Shaw JG, Kelly DJ
Title Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
Journal Reference Authors Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
Title TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
Journal Reference Authors Martin B, Quentin Y, Fichant G, Claverys JP
Title Independent evolution of competence regulatory cascades in streptococci?
Journal Reference Authors Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
Title The genetic basis of tetrathionate respiration in Salmonella typhimurium.
Journal Reference Authors Guvener ZT, Harwood CS
Title Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
Journal Reference Authors Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
Title Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
Journal Reference Authors Jiang M, Shao W, Perego M, Hoch JA
Title Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
Journal Reference Authors Jenal U
Title The role of proteolysis in the Caulobacter crescentus cell cycle and development.
Journal Reference Authors Jenal U, Galperin MY
Title Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
Journal Reference Authors Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
Title Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
Journal Reference Authors Pawlowski K, Klosse U, de Bruijn FJ
Title Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
Journal Reference Authors Chatterjee S, Almeida RP, Lindow S
Title Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
Journal Reference Authors Dow M
Title Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
Journal Reference Authors Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
Title Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
Journal Reference Authors Miller LD, Russell MH, Alexandre G
Title Diversity in bacterial chemotactic responses and niche adaptation.
Journal Reference Authors Eder S, Shi L, Jensen K, Yamane K, Hulett FM
Title A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
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