KEGG   PATHWAY: sscv00270
Entry
sscv00270                   Pathway                                
Name
Cysteine and methionine metabolism - Syngnathus scovelli (Gulf pipefish)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
sscv00270  Cysteine and methionine metabolism
sscv00270

Module
sscv_M00034  Methionine salvage pathway [PATH:sscv00270]
sscv_M00035  Methionine degradation [PATH:sscv00270]
sscv_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sscv00270]
Other DBs
GO: 0006534 0006555
Organism
Syngnathus scovelli (Gulf pipefish) [GN:sscv]
Gene
125966833  apip; methylthioribulose-1-phosphate dehydratase isoform X1 [KO:K08964] [EC:4.2.1.109]
125966900  [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
125967603  [KO:K14455] [EC:2.6.1.1]
125968618  mri1; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
125969008  [KO:K14454] [EC:2.6.1.1]
125969047  mtap; S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]
125969373  [KO:K00025] [EC:1.1.1.37]
125970397  [KO:K01251] [EC:3.13.2.1]
125970648  ldha; L-lactate dehydrogenase A chain isoform X1 [KO:K00016] [EC:1.1.1.27]
125970792  zgc:172121; homocysteine S-methyltransferase YbgG [KO:K00547] [EC:2.1.1.10]
125971337  tat; tyrosine aminotransferase isoform X1 [KO:K00815] [EC:2.6.1.5]
125972289  gclm; glutamate--cysteine ligase regulatory subunit [KO:K11205]
125972298  il4i1; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
125973300  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125973824  lacc1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
125975479  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
125975945  [KO:K01758] [EC:4.4.1.1]
125977250  [KO:K01251] [EC:3.13.2.1]
125977553  ahcy; adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
125978072  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) [KO:K00025] [EC:1.1.1.37]
125978647  got1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
125979014  gclc; glutamate--cysteine ligase catalytic subunit [KO:K11204] [EC:6.3.2.2]
125979038  mat1a; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
125979297  bhmt; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
125979459  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125979756  enoph1; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
125979767  [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
125980094  mat2aa; methionine adenosyltransferase II, alpha a [KO:K00789] [EC:2.5.1.6]
125980704  [KO:K17398] [EC:2.1.1.37]
125980840  sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125980897  adi1; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]
125981326  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
125981828  sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
125981973  mat2b; methionine adenosyltransferase 2 subunit beta isoform X1 [KO:K00789] [EC:2.5.1.6]
125983102  bcat2; branched-chain-amino-acid aminotransferase, mitochondrial [KO:K00826] [EC:2.6.1.42]
125983155  [KO:K01011] [EC:2.8.1.1 2.8.1.2]
125983159  [KO:K01011] [EC:2.8.1.1 2.8.1.2]
125983797  dnmt1; DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
125987927  cbsa; cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
125988051  ahcyl1; S-adenosylhomocysteine hydrolase-like protein 1 isoform X1 [KO:K01251] [EC:3.13.2.1]
125988132  srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
125988163  gss; glutathione synthetase [KO:K21456] [EC:6.3.2.3]
125988164  [KO:K21456] [EC:6.3.2.3]
125988165  [KO:K21456] [EC:6.3.2.3]
125989213  [KO:K17399] [EC:2.1.1.37]
125989512  [KO:K17399] [EC:2.1.1.37]
125989890  amd1; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
125990124  [KO:K17398] [EC:2.1.1.37]
125990974  mtr; methionine synthase [KO:K00548] [EC:2.1.1.13]
125992055  ldhba; L-lactate dehydrogenase B-A chain [KO:K00016] [EC:1.1.1.27]
125992375  ahcyl2b; adenosylhomocysteinase like 2b isoform X1 [KO:K01251] [EC:3.13.2.1]
125992496  bcat1; branched-chain-amino-acid aminotransferase, cytosolic [KO:K00826] [EC:2.6.1.42]
125993536  mat2ab; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
125993552  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
125993873  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125994694  [KO:K00544] [EC:2.1.1.5]
125994697  [KO:K00456] [EC:1.13.11.20]
125994699  [KO:K00456] [EC:1.13.11.20]
125994700  [KO:K00456] [EC:1.13.11.20]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01102  O-Phospho-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03431  S-Inosyl-L-homocysteine
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
sscv00010  Glycolysis / Gluconeogenesis
sscv00250  Alanine, aspartate and glutamate metabolism
sscv00260  Glycine, serine and threonine metabolism
sscv00290  Valine, leucine and isoleucine biosynthesis
sscv00430  Taurine and hypotaurine metabolism
sscv00480  Glutathione metabolism
sscv00620  Pyruvate metabolism
sscv00640  Propanoate metabolism
sscv00770  Pantothenate and CoA biosynthesis
sscv00900  Terpenoid backbone biosynthesis
sscv00920  Sulfur metabolism
KO pathway
ko00270   

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