KEGG   PATHWAY: sscv00260
Entry
sscv00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Syngnathus scovelli (Gulf pipefish)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sscv00260  Glycine, serine and threonine metabolism
sscv00260

Module
sscv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sscv00260]
sscv_M00047  Creatine pathway [PATH:sscv00260]
sscv_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sscv00260]
sscv_M00555  Betaine biosynthesis, choline => betaine [PATH:sscv00260]
sscv_M00621  Glycine cleavage system [PATH:sscv00260]
sscv_M00974  Betaine metabolism, animals, betaine => glycine [PATH:sscv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Syngnathus scovelli (Gulf pipefish) [GN:sscv]
Gene
125991534  threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
125983142  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
125976812  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
125985012  alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
125970725  alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
125968571  glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]
125988945  glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
125977490  glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
125968457  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
125978506  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
125980194  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
125970865  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
125973300  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
125993552  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
125972123  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
125984139  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
125990608  L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
125981213  L-threonine dehydrogenase 2 [KO:K15789] [EC:1.1.1.103]
125989376  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
125976835  5-aminolevulinate synthase, nonspecific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
125973597  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
125983240  retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
125993980  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
125988410  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
125970287  dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
125966811  glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
125970213  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
125993710  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
125979459  alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
125967130  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
125976197  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
125987758  choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
125969578  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
125979297  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
125994694  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
125979272  dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
125980042  sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
125981326  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
125987927  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
125975945  cystathionine gamma-lyase isoform X1 [KO:K01758] [EC:4.4.1.1]
125978938  L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
125980840  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125993873  L-serine dehydratase/L-threonine deaminase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
125984838  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sscv00010  Glycolysis / Gluconeogenesis
sscv00020  Citrate cycle (TCA cycle)
sscv00230  Purine metabolism
sscv00250  Alanine, aspartate and glutamate metabolism
sscv00270  Cysteine and methionine metabolism
sscv00290  Valine, leucine and isoleucine biosynthesis
sscv00330  Arginine and proline metabolism
sscv00470  D-Amino acid metabolism
sscv00564  Glycerophospholipid metabolism
sscv00600  Sphingolipid metabolism
sscv00620  Pyruvate metabolism
sscv00630  Glyoxylate and dicarboxylate metabolism
sscv00640  Propanoate metabolism
sscv00860  Porphyrin metabolism
sscv00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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