Entry Name Cell adhesion molecules - Ursus maritimus (polar bear)
Description Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map Other DBs Organism Ursus maritimus (polar bear) [GN:
umr ]
Gene 103663203 PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708 ]
103665644 PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471 ]
103667981 VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268 ]
103669446 CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492 ]
103669702 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
103671471 CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X1 [KO:K06458 ]
103671473 CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459 ]
103672538 CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474 ]
103673053 CXADR; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788 ]
103678768 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
103678797 IGSF11; LOW QUALITY PROTEIN: immunoglobulin superfamily member 11 [KO:K06791 ]
103678805 TIGIT; T-cell immunoreceptor with Ig and ITIM domains isoform X1 [KO:K16350 ]
103680864 VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747 ]
Reference Authors Barclay AN.
Title Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Journal Reference Authors Sharpe AH, Freeman GJ.
Title The B7-CD28 superfamily.
Journal Reference Authors Grewal IS, Flavell RA.
Title CD40 and CD154 in cell-mediated immunity.
Journal Reference Authors Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
Title CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
Journal Reference Authors Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Title Cell adhesion and polarity during immune interactions.
Journal Reference Authors Dejana E.
Title Endothelial cell-cell junctions: happy together.
Journal Reference Authors Bazzoni G.
Title The JAM family of junctional adhesion molecules.
Journal Reference Authors Becker BF, Heindl B, Kupatt C, Zahler S.
Title Endothelial function and hemostasis.
Journal Reference Authors Elangbam CS, Qualls CW Jr, Dahlgren RR.
Title Cell adhesion molecules--update.
Journal Reference Authors Muller WA.
Title Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Journal Reference Authors Yamagata M, Sanes JR, Weiner JA.
Title Synaptic adhesion molecules.
Journal Reference Authors Ethell IM, Pasquale EB.
Title Molecular mechanisms of dendritic spine development and remodeling.
Journal Reference Authors Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Title Making memories stick: cell-adhesion molecules in synaptic plasticity.
Journal Reference Authors Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Title Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Journal Reference Authors Dunican DJ, Doherty P.
Title The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Journal Reference Authors Girault JA, Peles E.
Title Development of nodes of Ranvier.
Journal Reference Authors Arroyo EJ, Scherer SS.
Title On the molecular architecture of myelinated fibers.
Journal Reference Authors Salzer JL.
Title Polarized domains of myelinated axons.
Journal Reference Authors Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Title Roles and modes of action of nectins in cell-cell adhesion.
Journal Reference Authors Nakanishi H, Takai Y.
Title Roles of nectins in cell adhesion, migration and polarization.
Journal Reference Authors Siu MK, Cheng CY.
Title Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Journal Reference Authors Lee NP, Cheng CY.
Title Adaptors, junction dynamics, and spermatogenesis.
Journal Reference Authors Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Title Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Journal Reference Authors Marthiens V, Gavard J, Lambert M, Mege RM.
Title Cadherin-based cell adhesion in neuromuscular development.
Journal Reference Authors Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Title Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Journal Related umr04610 Complement and coagulation cascades
umr04660 T cell receptor signaling pathway
umr04670 Leukocyte transendothelial migration
KO pathway
