KEGG   PATHWAY: umr04530
Entry
umr04530                    Pathway                                
Name
Tight junction - Ursus maritimus (polar bear)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
umr04530  Tight junction
umr04530

Other DBs
GO: 0005923
Organism
Ursus maritimus (polar bear) [GN:umr]
Gene
103656511  ITGB1; integrin beta-1 [KO:K05719]
103656515  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
103656694  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103656708  [KO:K16175]
103657060  SYMPK; symplekin [KO:K06100]
103657189  [KO:K06274]
103657269  MYH14; myosin-14 [KO:K10352]
103657330  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X5 [KO:K03456]
103657652  CLDN10; claudin-10 isoform X1 [KO:K06087]
103657723  [KO:K07374]
103658068  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X5 [KO:K08018]
103658340  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103658377  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
103658540  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
103658703  CLDN12; claudin-12 [KO:K06087]
103659105  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103659247  NF2; merlin isoform X2 [KO:K16684]
103659749  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
103659975  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
103660117  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103660276  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
103660466  CLDN7; claudin-7 [KO:K06087]
103660494  MYH10; myosin-10 [KO:K10352]
103660711  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
103660751  JAM3; junctional adhesion molecule C [KO:K06785]
103660799  AFDN; afadin isoform X1 [KO:K05702]
103660847  EZR; ezrin isoform X2 [KO:K08007]
103660868  CLDN20; claudin-20 [KO:K06087]
103660934  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
103660987  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103661071  ACTN4; alpha-actinin-4 [KO:K05699]
103661171  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
103661279  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103661560  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103662184  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
103662411  RDX; radixin isoform X1 [KO:K05762]
103662524  CLDN25; putative claudin-25 [KO:K06087]
103662531  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103662651  [KO:K12757]
103662658  [KO:K12757]
103662744  [KO:K07374]
103662753  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
103662770  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103662842  ROCK1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.39]
103662972  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103663073  PATJ; inaD-like protein isoform X1 [KO:K06092]
103663337  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
103663384  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
103663496  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
103663606  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
103663691  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103663821  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
103663872  OCLN; occludin isoform X1 [KO:K06088]
103663891  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103664066  TJAP1; tight junction-associated protein 1 [KO:K06105]
103664677  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103664816  SYNPO; synaptopodin [KO:K21112]
103665813  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103665925  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
103665939  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
103666578  CDC42; cell division control protein 42 homolog [KO:K04393]
103667511  CGN; cingulin [KO:K06102]
103667655  ACTR3; actin-related protein 3 [KO:K18584]
103667893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103668088  CLDN34; claudin-34 [KO:K06087]
103668408  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
103668507  CLDN9; claudin-9 [KO:K06087]
103668508  CLDN6; claudin-6 [KO:K06087]
103668692  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
103668838  MYH11; myosin-11 [KO:K10352]
103668894  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
103668919  CLDN2; claudin-2 [KO:K06087]
103669170  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
103669231  [KO:K07374]
103669237  [KO:K07374]
103669571  ARPC4; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 4 [KO:K05755]
103669776  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103669791  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103669834  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
103669983  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103669984  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103670062  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
103670086  ACTB; actin, cytoplasmic 1 [KO:K05692]
103670095  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103670199  CLDN15; claudin-15 isoform X1 [KO:K06087]
103670226  CLDN3; claudin-3 [KO:K06087]
103670227  CLDN4; claudin-4 [KO:K06087]
103670326  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103670508  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
103670673  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
103670827  CLDN19; claudin-19 isoform X1 [KO:K06087]
103670861  JUN; transcription factor AP-1 [KO:K04448]
103671069  CTTN; src substrate cortactin isoform X1 [KO:K06106]
103671139  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103671225  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
103671799  ACTR2; actin-related protein 2 [KO:K17260]
103671954  PALS1; MAGUK p55 subfamily member 5 isoform X2 [KO:K06091]
103672029  F11R; junctional adhesion molecule A [KO:K06089]
103672077  [KO:K06448]
103672078  [KO:K06448]
103672079  [KO:K06448]
103672081  [KO:K06448]
103672082  [KO:K06448]
103672083  [KO:K06448]
103672084  [KO:K06448]
103672085  [KO:K06448]
103672138  [KO:K06448]
103672141  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
103672410  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103672940  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
103673068  JAM2; junctional adhesion molecule B [KO:K06735]
103673083  CLDN17; claudin-17 [KO:K06087]
103673084  CLDN8; claudin-8 [KO:K06087]
103673212  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
103673224  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
103673231  CLDN14; claudin-14 [KO:K06087]
103673235  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
103673291  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103673652  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
103673702  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
103674284  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
103674291  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103674409  PCNA; proliferating cell nuclear antigen [KO:K04802]
103674739  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103674825  RHOA; transforming protein RhoA [KO:K04513]
103675043  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
103675333  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
103675453  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103675456  TUBA1B; tubulin alpha-1B chain [KO:K07374]
103675457  [KO:K07374]
103675459  [KO:K07374]
103675693  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
103675858  BVES; blood vessel epicardial substance [KO:K21108]
103675980  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
103676021  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
103676022  CLDN1; claudin-1 [KO:K06087]
103676078  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
103676154  CLDN11; claudin-11 [KO:K06087]
103676211  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
103676280  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103676552  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
103676590  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
103676773  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103676851  CGNL1; cingulin-like protein 1 [KO:K21110]
103676947  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103677160  RAB8A; ras-related protein Rab-8A [KO:K07901]
103678332  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
103678391  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
103678447  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
103678650  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
103678739  CLDN18; claudin-18 isoform X2 [KO:K06087]
103678777  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
103678920  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
103678977  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
103679171  RAB8B; ras-related protein Rab-8B [KO:K07902]
103679726  CLDN22; claudin-22 [KO:K06087]
103679758  AMOT; angiomotin [KO:K16819]
103679990  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103680129  [KO:K06099]
103681143  MSN; moesin [KO:K05763]
103681709  CRB3; protein crumbs homolog 3 [KO:K06090]
103681779  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
103681826  TJP3; tight junction protein ZO-3 [KO:K06097]
103681888  MAP2K7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103681898  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
103682183  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103682598  MYL6B; myosin light chain 6B [KO:K12751]
103682613  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
103682622  DLG3; LOW QUALITY PROTEIN: disks large homolog 3 [KO:K21098]
121099919  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
121100753  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121103231  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
121105176  [KO:K07839]
121105626  CLDN23; claudin-23 [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
umr04520  Adherens junction
umr04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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