KEGG    Network variation - Chromosome cohesion and segregation
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ENTRYnt06512
NameChromosome cohesion and segregation
CategoryPathway view; Cellular process
Pathwayhsa04110 Cell cycle
DiseaseH00631 Cornelia de Lange syndrome
H00773 Autosomal dominant intellectual developmental disorder
H02632 PP2A-related neurodevelopmental disorder
H00269 Primary microcephaly
Display drug-target relation   disease type
N01482    CohesinATRX=Cohesin=NIPBL+MAU2DDX11=Cohesin+NIPBL+MAU2
    CDLS2/DEE85 SMC1*
    CDLS3 SMC3*
    CDLS4 RAD21*
    MRD47 STAG1*
    HPE13/MKMS STAG2*
      ATRX*
    CDLS1       NIPBL*
    WABS         DDX11*
 
N01813      H3K27ac=BRD4=NIPBL
    CDLS6     BRD4*
 
N01483          HDAC8ESCO1,ESCO2SMC3CDCA5
    RBS/JHS         ESCO2*
    CDLS5       HDAC8*
 
N01484        STAG1,STAG2=PDS5+WAPLCDCA5,CTCF=STAG+PDS5+WAPL
    MRD21         CTCF*
 
N01485          SGO1+PP2APLK1,AURKB,CDK1STAG+CDCA5
    CAID       SGO1*
    NEDLBA       PPP2CA*
    MRD36       PPP2R1A*
    SCLC/NSCLC       PPP2R1B*
    MRD35       PPP2R5D*
 
N01486        ANAPC+CDC20PTTG1ESPL1RAD21
    RTS1     ANAPC1*
    FERBON     ANAPC7*
 
N01497            PP2A=Condensin_IITOP2A+KIF4A+DNMT3B=Condensin_I
    MCPH22           NCAPD3*
    3KS           NCAPG2*
    XLID100             KIF4A*
    ICF1/FSHD4             DNMT3B*
    MCPH23               NCAPH*
    MCPH21               NCAPD2*
 
N01498            MCPH1NCAPG2SMC2
    MCPH1         MCPH1*
 
N01499            PLK1,AURKB,CDK1NCAPD3,NCAPG2,NCAP..
N01500                AURKB,CDK1NCAPD2,NCAPG,NCAPH
N01501                CK2SMC4,NCAPD2,NCAPG,..
    OCNDS             CSNK2A1*

Disease nameDisease category
CDLS2/DEE85H00631Cornelia de Lange syndromeCongenital malformation
H00606Early infantile epileptic encephalopathyNervous system disease
CDLS3H00631Cornelia de Lange syndromeCongenital malformation
CDLS4H00631Cornelia de Lange syndromeCongenital malformation
MRD47H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
HPE13/MKMSH00267HoloprosencephalyCongenital malformation
H02582Mullegama-Klein-Martinez syndromeCongenital malformation
ATRX/MRXHF1H01752ATR-X syndromeCongenital malformation
H02583X-linked intellectual disability-hypotonic facies syndromeCongenital malformation
CDLS1H00631Cornelia de Lange syndromeCongenital malformation
WABSH00914Warsaw breakage syndromeCongenital malformation
CDLS6H00631Cornelia de Lange syndromeCongenital malformation
RBS/JHSH00572Roberts-SC phocomelia syndromeCongenital malformation
H02581Juberg-Hayward syndromeCongenital malformation
CDLS5H00631Cornelia de Lange syndromeCongenital malformation
MRD21H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
CAIDH02122Chronic atrial and intestinal dysrhythmiaCardiovascular disease
NEDLBAH02632Houge-Janssens syndromeCongenital malformation
MRD36H02632Houge-Janssens syndromeCongenital malformation
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
SCLC/NSCLCH00013Small cell lung cancerCancer
H00014Non-small cell lung cancerCancer
MRD35H02632Houge-Janssens syndromeCongenital malformation
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
RTS1H01734Rothmund-Thomson syndromeCongenital malformation
FERBONH02584Ferguson-Bonni neurodevelopmental syndromeCongenital malformation
MCPH22H00269Primary microcephalyCongenital malformation
3KSH02707Khan-Khan-Katsanis syndromeCongenital malformation
XLID100H00480X-linked intellectual developmental disorderMental and behavioural disorder
ICF1/FSHD4H02308Immunodeficiency-centromeric instability-facial anomalies syndromeImmune system disease
H00591Facioscapulohumeral muscular dystrophyNervous system disease
MCPH23H00269Primary microcephalyCongenital malformation
MCPH21H00269Primary microcephalyCongenital malformation
MCPH1H00269Primary microcephalyCongenital malformation
OCNDSH02460Neurodevelopmental disorder with dysmorphic facies and skeletal anomaliesCongenital malformation