KEGG    Network variation - Necroptosis
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ENTRYnt06527
NameNecroptosis
CategoryPathway view; Cellular process
Pathwayhsa04217 Necroptosis
Display drug-target relation   disease type
N01621        TNFTNFRSF1A(TRAF2/5+TRADD+RIP..
    TRAPS/MS5       TNFRSF1A*
N01583          XIAP(RIPK1+RIPK3+FADD+..
    XLP2       XIAP*
N01631        TNFSF10TNFRSF10(RIPK1+RIPK3)
    HNSCC       TNFRSF10B*
N01632      FASLGFASFADD(RIPK1+RIPK3)
    ALPS1B   FASLG*
    ALPS1A     FAS*
N01625          CYLD(RIPK1+RIPK3)
    BRSS/FC/MFT/FTDALS8       CYLD*
N01663          CASP8(RIPK1+RIPK3)
    ALPS2B       CASP8*
N01650          SQSTM1(RIPK1+RIPK3)
    FTDALS3       SQSTM1*
N01662    IFNIFNRJAKsSTAT+IRF9(RIPK1+RIPK3)
    IMD44       STAT2*
    IMD65       IRF9*
    IMD57         RIPK1*
    AIEFL         RIPK1*
 
N01634      TLR4TICAM2TICAM1RIPK3
    ARMD10   TLR4*
N01633        TLR3TICAM1RIPK3
    IIAE2     TLR3*
    IIAE6       TICAM1*

Disease nameDisease category
TRAPS/MS5H00912Tumor necrosis factor receptor-associated periodic syndromeImmune system disease
H01490Multiple sclerosisImmune system disease
XLP2H01969X-linked lymphoproliferative syndromePrimary immunodeficiency
HNSCCH02610Head and neck squamous cell carcinomaCancer
ALPS1BH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
ALPS1AH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
BRSS/FC/MFT/FTDALS8H00827Brooke-Spiegler syndromeNeoplasm
H00828Familial cylindromatosisNeoplasm
H00829Multiple familial trichoepitheliomaNeoplasm
H02342Frontotemporal dementia and amyotrophic lateral sclerosisNervous system disease
ALPS2BH00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
FTDALS3H02342Frontotemporal dementia and amyotrophic lateral sclerosisNervous system disease
IMD44H02525Disorders of innate immunityImmune system disease
IMD65H02525Disorders of innate immunityImmune system disease
IMD57H02525Disorders of innate immunityImmune system disease
AIEFLH02620Autoinflammation with episodic fever and lymphadenopathyImmune system disease
ARMD10H00821Age-related macular degenerationNervous system disease
IIAE2H02536Infection-induced acute encephalopathyNervous system disease
IIAE6H02536Infection-induced acute encephalopathyNervous system disease