KEGG   PATHWAY: ccan05022
Entry
ccan05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Castor canadensis (American beaver)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ccan05022  Pathways of neurodegeneration - multiple diseases
ccan05022

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109700792  App; amyloid beta A4 protein isoform X1 [KO:K04520]
109684813  Mapt; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
109701230  Snca; alpha-synuclein isoform X1 [KO:K04528]
109689654  Tardbp; LOW QUALITY PROTEIN: TAR DNA-binding protein 43 [KO:K23600]
109690879  LOW QUALITY PROTEIN: TAR DNA-binding protein 43-like [KO:K23600]
109682708  Fus; RNA-binding protein FUS [KO:K13098]
109700071  Sod1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
109683418  Atxn2l; ataxin-2-like protein isoform X1 [KO:K23625]
109695404  Atxn2; ataxin-2 isoform X1 [KO:K23625]
109687432  Htt; LOW QUALITY PROTEIN: huntingtin [KO:K04533]
109694285  Atxn1l; ataxin-1-like [KO:K23616]
109698519  Atxn1; LOW QUALITY PROTEIN: ataxin-1 [KO:K23616]
109682353  Atxn3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
109699373  Prnp; major prion protein [KO:K05634]
109693848  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
109678968  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
109689428  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
109687065  Sptbn2; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 2 [KO:K23932]
109674757  LOW QUALITY PROTEIN: metabotropic glutamate receptor 5-like [KO:K04604]
109699997  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
109700025  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
109699980  uncharacterized protein LOC109699980 isoform X1 [KO:K04634]
109688031  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase parkin-like [KO:K04556] [EC:2.3.2.31]
109683285  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
109684223  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109701244  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109683399  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
109687351  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109683738  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
109693140  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
109684633  LOW QUALITY PROTEIN: short transient receptor potential channel 3-like [KO:K04966]
109694673  Sigmar1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
109699340  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
109674831  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
109687056  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
109686691  Itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109695821  Ryr1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
109682314  Ryr2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
109689421  Ryr3; ryanodine receptor 3 [KO:K04963]
109692888  Pdyn; proenkephalin-B [KO:K15840]
109674497  Dlg4; disks large homolog 4 isoform X1 [KO:K11828]
109687368  glutamate receptor ionotropic, NMDA 1 [KO:K05208]
109679370  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
109683576  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
109677813  glutamate receptor 1 [KO:K05197]
109677927  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
109676919  Gria4; glutamate receptor 4 [KO:K05200]
109693749  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
109674812  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109697195  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
109696593  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109697636  Stx1a; syntaxin-1A isoform X1 [KO:K04560]
109674332  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
109683479  Atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
109694320  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109681722  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
109681743  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109693684  Psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
109690752  Psen2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
109681659  Derl1; derlin-1 isoform X1 [KO:K11519]
109685307  Vcp; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
109676707  Uba52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
109677773  LOW QUALITY PROTEIN: ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
109681758  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
109692310  Ubb; LOW QUALITY PROTEIN: polyubiquitin-B [KO:K04551]
109700514  Ubc; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
109697268  Psma6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
109696387  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
109682394  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
109674794  proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
109689093  Psma7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
109685939  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
109695446  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
109700105  Psma3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
109684735  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
109688250  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
109698506  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
109683658  Psmb2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
109685658  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
109700766  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
109681173  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
109686860  26S protease regulatory subunit 7 [KO:K03061]
109699136  Psmc1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
109697926  Psmc4; 26S protease regulatory subunit 6B [KO:K03063]
109683953  Psmc6; 26S protease regulatory subunit 10B [KO:K03064]
109696180  Psmc3; 26S protease regulatory subunit 6A [KO:K03065]
109700522  Psmc5; 26S protease regulatory subunit 8 [KO:K03066]
109694093  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
109681474  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
109681478  26S proteasome non-ATPase regulatory subunit 1-like [KO:K03032]
109694416  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
109686402  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
109696998  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
109684901  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
109692680  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
109697205  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
109699533  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
109681222  Psmd4; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
109692595  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
109695827  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
109689085  Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
109683819  Sem1; 26S proteasome complex subunit DSS1 [KO:K10881]
109690785  Uchl1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
109692972  Uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
109702067  ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
109692693  Uba7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
109684378  Ube2l3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
109688989  Ube2l6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
109681155  Ube2j2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
109692834  Ube2j1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
109694960  Ube2g2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
109686259  Ube2g1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
109679762  Gpr37; prosaposin receptor GPR37 [KO:K04243]
109684352  Sept5; septin-5 isoform X1 [KO:K04557]
109686552  Sncaip; synphilin-1 isoform X1 [KO:K04558]
109683432  Hspa5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
109690603  Vapb; LOW QUALITY PROTEIN: vesicle-associated membrane protein-associated protein B/C [KO:K10707]
109697613  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
109686362  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
109675714  LOW QUALITY PROTEIN: DNA damage-inducible transcript 3 protein-like [KO:K04452]
109690244  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
109674432  serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109699331  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
109697041  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
109698434  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109703004  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109688533  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
109699492  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
109693025  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109698262  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
109689686  Pink1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
31082893  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
31082897  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
31082912  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
31082915  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
31082914  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
31082919  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
109692322  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
109699960  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
109676035  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
109682051  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
109682109  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
109684007  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
109686065  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
109687643  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
109696991  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
109680002  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
109695224  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
109689363  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
109698437  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
109692485  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
109697168  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
109699584  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
109699635  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
109688206  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
109694714  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
109699151  Ndufa13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
109682016  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
109688480  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
109686654  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
109686655  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
109696108  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
109683805  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
109686637  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
109685921  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
109688116  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
109690201  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
109701145  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
109697500  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
109693207  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
109696178  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
109691798  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
109699540  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
109699676  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
109691009  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
109692075  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
109691474  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
109683797  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
109693457  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
109689825  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
109690415  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
109699440  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
109693090  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
31082921  CYTB; cytochrome b [KO:K00412]
109690795  cytochrome c1, heme protein, mitochondrial [KO:K00413]
109685725  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
109686287  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
109695241  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
109691931  cytochrome b-c1 complex subunit 7 [KO:K00417]
109696602  cytochrome b-c1 complex subunit 8 [KO:K00418]
109681642  cytochrome b-c1 complex subunit 9 [KO:K00419]
109699487  cytochrome b-c1 complex subunit 10 [KO:K00420]
109684225  cytochrome b-c1 complex subunit 10 [KO:K00420]
31082910  COX3; cytochrome c oxidase subunit III [KO:K02262]
31082903  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
31082906  COX2; cytochrome c oxidase subunit II [KO:K02261]
109691792  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
109691841  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
109695951  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
109700699  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
109699535  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
109696164  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
109696280  cytochrome c oxidase subunit 6B2 [KO:K02267]
109689208  cytochrome c oxidase subunit 6B1 [KO:K02267]
109696639  cytochrome c oxidase subunit 6B2 [KO:K02267]
109690697  cytochrome c oxidase subunit 6C-2 [KO:K02268]
109688745  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
109697439  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
109689754  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
109686755  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
109680062  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
109701172  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
109699534  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
109683255  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
109687234  Atp5a1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
109686114  Atp5b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
109692259  Atp5c1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
109691024  Atp5d; ATP synthase subunit delta, mitochondrial [KO:K02134]
109682729  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
109699108  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
109692780  Atp5e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
31082909  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
109682505  Atp5f1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
109684083  Atp5g2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
109689845  Atp5g3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
109692958  Atp5g1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
109687580  Atp5h; LOW QUALITY PROTEIN: ATP synthase subunit d, mitochondrial [KO:K02138]
109685750  Atp5o; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
109695535  ATP synthase subunit O, mitochondrial-like [KO:K02137]
109696391  Atp5j; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
31082908  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
109693757  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109697584  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
109693210  Tomm40l; LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40B [KO:K11518]
109692403  Tomm40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
109688244  calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
109674958  serine/threonine-protein phosphatase with EF-hands 1-like [KO:K02183]
109674302  calmodulin-alpha-like [KO:K02183]
109691449  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
109696281  Calm2; calmodulin [KO:K02183]
109688234  Calml4; calmodulin-like protein 4 [KO:K02183]
109699140  Calm1; calmodulin [KO:K02183]
109700840  Calml5; calmodulin-like protein 5 [KO:K02183]
109700844  calmodulin-like protein 3 [KO:K02183]
109691756  calmodulin-alpha-like [KO:K02183]
109691221  Calm3; calmodulin [KO:K02183]
109700908  calmodulin [KO:K02183]
109680203  calmodulin-alpha-like [KO:K02183]
109688186  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
109681777  Ppp3cc; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
109682626  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109696247  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
109693705  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
109683261  Bad; bcl2-associated agonist of cell death [KO:K02158]
109689125  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109691142  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
109700274  Fadd; FAS-associated death domain protein [KO:K02373]
109689613  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
109678183  Bid; BH3-interacting domain death agonist isoform X1 [KO:K04726]
109682703  Bax; apoptosis regulator BAX [KO:K02159]
109686692  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
109700877  Lrrk2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
109692441  Htra2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
109681684  Trap1; LOW QUALITY PROTEIN: heat shock protein 75 kDa, mitochondrial [KO:K09488]
109693642  Vdac2; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2 [KO:K15040]
109700211  voltage-dependent anion-selective channel protein 2 [KO:K15040]
109696398  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
109675843  ADP/ATP translocase 2 [KO:K05863]
109688777  Slc25a6; ADP/ATP translocase 3 [KO:K05863]
109681419  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
109684937  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
109687741  Ppif; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
109679656  cytochrome c-like [KO:K08738]
109697493  cytochrome c, somatic [KO:K08738]
109690717  cytochrome c-like [KO:K08738]
109690039  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109692548  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
109678444  caspase-3 [KO:K02187] [EC:3.4.22.56]
109678454  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109685152  Hip1; huntingtin-interacting protein 1 [KO:K04559]
109691159  Ift57; intraflagellar transport protein 57 homolog [KO:K04638]
109702046  Hsd17b10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
109692806  Ppid; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
109697924  Park7; protein deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
109691766  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
109689665  Mfn1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
109683965  Mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
109690083  optineurin-like isoform X1 [KO:K19946]
109686732  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
109696466  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
109685898  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
109698137  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
109692593  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
109695376  Wdr41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
109688188  Smcr8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
109682656  CUNH9orf72; protein C9orf72 homolog isoform X1 [KO:K23609]
109689056  Rab8a; ras-related protein Rab-8A [KO:K07901]
109700437  Rab39b; ras-related protein Rab-39B [KO:K07925]
109685030  Rab1a; ras-related protein Rab-1A [KO:K07874]
109689656  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109697545  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
109687740  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
109701402  Atg101; autophagy-related protein 101 isoform X1 [KO:K19730]
109696258  Atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
109690087  Rb1cc1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
109692005  Ambra1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
109687340  Becn1; beclin-1 isoform X1 [KO:K08334]
109693432  Becn2; beclin-2 [KO:K08334]
109678218  phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
109698491  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
109690447  Nrbf2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
109701401  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
109687168  Atg2a; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
109697559  Atg2b; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
109687467  WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
109687468  WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
109694858  Wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
109681398  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
109687107  Zfyve1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
109683732  Als2; alsin isoform X1 [KO:K04575]
109703335  ras-related protein Rab-5A-like [KO:K07887]
109692646  Rab5a; ras-related protein Rab-5A [KO:K07887]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109692171  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
109700001  Fig4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
109678751  polyphosphoinositide phosphatase-like isoform X1 [KO:K22913] [EC:3.1.3.-]
109686435  Spg11; LOW QUALITY PROTEIN: spatacsin [KO:K19026]
109690391  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
109682791  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109683967  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
109686666  Daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
109692052  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
109698990  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
109697389  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109689865  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
109689849  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
109697648  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
109686387  Nos1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
109687120  Ccs; copper chaperone for superoxide dismutase [KO:K04569]
109697843  Gpx1; glutathione peroxidase 1 isoform X1 [KO:K00432] [EC:1.11.1.9]
109689527  uncharacterized protein LOC109689527 [KO:K00432] [EC:1.11.1.9]
109689528  glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
109694839  Gpx6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
109694840  Gpx5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109691134  Gpx2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
109694344  Gpx3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
109698513  Cat; LOW QUALITY PROTEIN: catalase [KO:K03781] [EC:1.11.1.6]
109690230  Prph; peripherin isoform X1 [KO:K07607]
109677700  Nefl; neurofilament light polypeptide [KO:K04572]
109677699  Nefm; LOW QUALITY PROTEIN: neurofilament medium polypeptide [KO:K04573]
109681637  Nefh; neurofilament heavy polypeptide [KO:K04574]
109674509  Kif5c; kinesin heavy chain [KO:K10396]
109682195  Kif5b; kinesin-1 heavy chain [KO:K10396]
109686156  Kif5a; kinesin heavy chain isoform X1 [KO:K10396]
109687128  Klc2; kinesin light chain 2 [KO:K10407]
109697510  Klc1; LOW QUALITY PROTEIN: kinesin light chain 1 [KO:K10407]
109682145  Klc4; kinesin light chain 4 [KO:K10407]
109692393  Klc3; kinesin light chain 3 [KO:K10407]
109675180  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
109690215  tubulin alpha-1B chain-like [KO:K07374]
109690217  Tuba1a; tubulin alpha-1A chain [KO:K07374]
109690218  LOW QUALITY PROTEIN: tubulin alpha-1C chain-like [KO:K07374]
109684369  tubulin alpha-3 chain [KO:K07374]
109700648  tubulin alpha-8 chain isoform X1 [KO:K07374]
109691074  Tuba4a; tubulin alpha-4A chain [KO:K07374]
109687385  Tubb4b; tubulin beta-4B chain [KO:K07375]
109693530  Tubb; tubulin beta chain [KO:K07375]
109698912  Tubb2b; tubulin beta-2B chain [KO:K07375]
109698939  LOW QUALITY PROTEIN: tubulin beta chain-like [KO:K07375]
109697895  tubulin beta chain-like [KO:K07375]
109692761  Tubb3; tubulin beta-3 chain [KO:K07375]
109694299  Tubb4a; tubulin beta-4A chain [KO:K07375]
109702887  tubulin beta chain-like [KO:K07375]
109692781  Tubb1; tubulin beta-1 chain [KO:K07375]
109696098  Tubb6; tubulin beta-6 chain [KO:K07375]
109685333  Gsk3b; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
109687013  Csnk2a2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
109687015  Csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
109694572  Csnk2b; casein kinase II subunit beta [KO:K03115]
109695020  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
109692432  Dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
109686351  Dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
109694671  Dctn3; dynactin subunit 3 [KO:K10425]
109696920  Dctn4; dynactin subunit 4 [KO:K10426]
109699638  Dctn5; dynactin subunit 5 [KO:K10427]
109694770  Dctn6; dynactin subunit 6 isoform X1 [KO:K10428]
109700697  Actr1b; beta-centractin [KO:K16575]
109691297  Actr1a; alpha-centractin [KO:K16575]
109700131  Actr10; actin-related protein 10 [KO:K16576]
109695788  Hap1; huntingtin-associated protein 1 [KO:K04647]
109702058  LOW QUALITY PROTEIN: huntingtin-associated protein 1-like [KO:K04647]
109674623  LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal-like [KO:K10408]
109678840  dynein heavy chain 8, axonemal-like [KO:K10408]
109682687  dynein heavy chain 17, axonemal [KO:K10408]
109675150  dynein heavy chain 5, axonemal-like [KO:K10408]
109684876  Dnah10; LOW QUALITY PROTEIN: dynein heavy chain 10, axonemal [KO:K10408]
109693002  Dnah9; dynein heavy chain 9, axonemal [KO:K10408]
109700971  dynein heavy chain 8, axonemal [KO:K10408]
109702384  dynein heavy chain 6, axonemal [KO:K10408]
109698832  Dnah3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
109695258  Dnah14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
109692467  Dnah1; LOW QUALITY PROTEIN: dynein heavy chain 1, axonemal [KO:K10408]
109701339  LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal-like [KO:K10408]
109702157  Dnah7; dynein heavy chain 7, axonemal [KO:K10408]
109683156  LOW QUALITY PROTEIN: dynein heavy chain 17, axonemal-like [KO:K10408]
109695897  Dnali1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
109681896  Dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
109697031  Dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
109688390  Dnal1; dynein light chain 1, axonemal [KO:K10411]
109692637  Dnal4; dynein light chain 4, axonemal [KO:K10412]
109685908  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109685909  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109690704  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109696394  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109687155  Capn1; LOW QUALITY PROTEIN: calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
109677038  Capn2; LOW QUALITY PROTEIN: calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
109694445  Cdk5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
109688558  Casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
109679186  dickkopf-related protein 2 [KO:K02165]
109679185  uncharacterized protein LOC109679185 [KO:K02165]
109700390  Dkk1; dickkopf-related protein 1 [KO:K02165]
109696399  Dkk4; dickkopf-related protein 4 [KO:K02165]
109694825  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
109684416  Wnt2; protein Wnt-2 [KO:K00182]
109681721  Wnt2b; protein Wnt-2b [KO:K00182]
109684805  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
109677070  Wnt3a; protein Wnt-3a [KO:K00312]
109694918  Wnt4; protein Wnt-4 [KO:K00408]
109683366  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
109683371  Wnt5b; protein Wnt-5b [KO:K00444]
109693790  Wnt6; protein Wnt-6 [KO:K00445]
109679085  protein Wnt-7a-like [KO:K00572]
109699751  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
109700179  Wnt8a; protein Wnt-8a [KO:K00714]
109698141  Wnt8b; protein Wnt-8b [KO:K00714]
109700763  Wnt9a; protein Wnt-9a [KO:K01064]
109702078  Wnt9b; protein Wnt-9b [KO:K01064]
109694821  Wnt10b; protein Wnt-10b [KO:K01357]
109693094  Wnt10a; protein Wnt-10a [KO:K01357]
109698403  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
109685536  Wnt16; protein Wnt-16 [KO:K01558]
109683768  Fzd7; frizzled-7 [KO:K02432]
109677487  Fzd1; frizzled-1 [KO:K02432]
109686522  Fzd2; frizzled-2 [KO:K02235]
109695813  Fzd3; frizzled-3 [KO:K02329]
109695029  Fzd4; frizzled-4 [KO:K02354]
109692648  Fzd5; frizzled-5 [KO:K02375]
109700329  Fzd8; frizzled-8 [KO:K02375]
109694264  Fzd6; frizzled-6 [KO:K02376]
109695912  Fzd10; frizzled-10 [KO:K02842]
109702389  Fzd9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
109684698  Lrp6; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6 [KO:K03068]
109689899  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like [KO:K03068]
109692849  casein kinase I [KO:K08960] [EC:2.7.11.1]
109674455  Dvl2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
109681149  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
109694105  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
109695300  Frat1; proto-oncogene FRAT1 [KO:K03069]
109695293  Frat2; GSK-3-binding protein FRAT2 [KO:K03096]
109694685  Axin1; axin-1 isoform X1 [KO:K02157]
109681311  Axin2; axin-2 [KO:K04385]
109691007  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
109699342  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
109689873  Ctnnb1; catenin beta-1 [KO:K02105]
109690568  Csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
109702106  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
109702984  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
109690410  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
109698042  Hras; GTPase HRas isoform X1 [KO:K02833]
109687060  Kras; GTPase KRas [KO:K07827]
109696062  Nras; GTPase NRas [KO:K07828]
109696670  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
109682021  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
109698982  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
109694940  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
109687824  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109687808  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
109683259  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109684381  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
109684181  Nox1; NADPH oxidase 1 isoform X1 [KO:K08008]
109698413  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
109678002  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
109687142  Rela; transcription factor p65 isoform X1 [KO:K04735]
109682963  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109693015  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
109685138  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
109679557  Il6; interleukin-6 [KO:K05405]
109702296  Il1a; interleukin-1 alpha [KO:K04383]
109701168  Il1b; interleukin-1 beta isoform X1 [KO:K04519]
109694805  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
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Related
pathway
ccan00190  Oxidative phosphorylation
ccan03050  Proteasome
ccan04020  Calcium signaling pathway
ccan04120  Ubiquitin mediated proteolysis
ccan04137  Mitophagy - animal
ccan04140  Autophagy - animal
ccan04141  Protein processing in endoplasmic reticulum
ccan04142  Lysosome
ccan04210  Apoptosis
ccan04310  Wnt signaling pathway
ccan04724  Glutamatergic synapse
ccan04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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