KEGG   PATHWAY: ecb05014
Entry
ecb05014                    Pathway                                
Name
Amyotrophic lateral sclerosis - Equus caballus (horse)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ecb05014  Amyotrophic lateral sclerosis
ecb05014

Organism
Equus caballus (horse) [GN:ecb]
Gene
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100033888  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
100054988  BID; BH3-interacting domain death agonist [KO:K04726]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100053597  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100054674  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100052552  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100053958  CYCS; cytochrome c [KO:K08738]
111768755  cytochrome c, testis-specific [KO:K08738]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100034083  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100033855  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
807846  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
807844  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
807855  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
807852  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
807851  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
807853  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
807848  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100059569  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100054445  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100057691  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X4 [KO:K03944]
100058835  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100061811  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
111772123  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
111767785  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
111767790  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100052169  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100052985  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
106783042  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100071532  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100066991  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100067562  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100051504  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100057698  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100069079  NDUFAB1; acyl carrier protein, mitochondrial isoform X1 [KO:K03955]
100065070  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100146253  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100630425  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100064695  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100067936  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100070815  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100058402  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100630340  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100064992  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
100060451  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100057623  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100065553  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100060719  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100066330  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2 [KO:K03934] [EC:7.1.1.2]
100066089  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100058223  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
100063168  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
100054377  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100071879  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
100068855  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
100053392  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100629515  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100630892  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100034244  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
100050091  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100065940  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X3 [KO:K00236]
100629334  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
100053634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
807847  CYTB; cytochrome b [KO:K00412]
100146668  CYC1; cytochrome c1, heme protein, mitochondrial [KO:K00413]
100053786  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial isoform X2 [KO:K00414]
100057847  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100051878  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100059627  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
111767815  cytochrome b-c1 complex subunit 8 [KO:K00418]
100630846  cytochrome b-c1 complex subunit 9 [KO:K00419]
100147519  cytochrome b-c1 complex subunit 10 [KO:K00420]
807856  COX3; cytochrome c oxidase subunit III [KO:K02262]
807850  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
807845  COX2; cytochrome c oxidase subunit II [KO:K02261]
100053548  COX4I2; cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100056171  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100051391  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100061973  COX5B; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100053420  COX6A1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100063197  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100051249  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
102149678  cytochrome c oxidase subunit 6B2 [KO:K02267]
100055813  cytochrome c oxidase subunit 6C [KO:K02268]
100053736  COX7A2L; cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100630209  LOW QUALITY PROTEIN: uncharacterized protein LOC100630209 [KO:K02270]
106782100  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100630758  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100629332  COX7B2; cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100630549  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111770393  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
111775959  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100053178  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
100059825  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100069978  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X3 [KO:K02136]
100146850  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
100630568  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
807854  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100058893  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
100069523  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100053347  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
100064131  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
100052170  ATP5PD; ATP synthase subunit d, mitochondrial isoform X2 [KO:K02138]
100052131  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
100066379  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
807849  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100062974  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100066580  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
100146715  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
100070639  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
100072824  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
100071784  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
100057832  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
100056689  OPTN; optineurin [KO:K19946]
100067231  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
100060547  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100146217  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
100060830  MAP1LC3C; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
102147898  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
102150519  microtubule-associated proteins 1A/1B light chain 3 beta 2-like [KO:K10435]
100630367  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
100051650  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
100051339  TANK; TRAF family member-associated NF-kappa-B activator isoform X4 [KO:K12650]
100065484  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
100050558  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
100053503  C23H9orf72; protein C9orf72 homolog [KO:K23609]
100147248  RAB8A; ras-related protein Rab-8A isoform X2 [KO:K07901]
100062885  RAB39B; ras-related protein Rab-39B [KO:K07925]
100051331  RAB1A; ras-related protein Rab-1A [KO:K07874]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100073154  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100062689  ATG101; autophagy-related protein 101 isoform X2 [KO:K19730]
100050734  ATG13; autophagy-related protein 13 [KO:K08331]
100050327  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
100050652  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X5 [KO:K17985]
100060790  BECN2; beclin-2 [KO:K08334]
100052295  BECN1; beclin-1 isoform X1 [KO:K08334]
100052647  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X2 [KO:K08333] [EC:2.7.11.1]
100050443  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
100072436  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
100053039  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
100050653  ATG2A; autophagy-related protein 2 homolog A isoform X4 [KO:K17906]
100054652  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100053194  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X2 [KO:K17908]
100060823  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
100066250  ALS2; alsin isoform X1 [KO:K04575]
100051997  RAB5A; ras-related protein Rab-5A [KO:K07887]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100070130  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
100066727  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
100070629  SPG11; spatacsin isoform X1 [KO:K19026]
100057357  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100067434  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
100072862  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100061874  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102148270  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
100050402  UBQLN2; ubiquilin-2 [KO:K04523]
100063909  UBQLN4; ubiquilin-4 [KO:K04523]
100052573  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
100069323  ubiquilin-3 [KO:K04523]
100068225  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
100057344  DERL1; derlin-1 isoform X1 [KO:K11519]
100050805  PSMA6; proteasome subunit alpha type-6 isoform X2 [KO:K02730] [EC:3.4.25.1]
100064293  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
100050569  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
100064417  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
100057828  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
100061457  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
100056224  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
100050987  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
100072870  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
100067317  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
100068477  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
100055325  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100052570  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
100051957  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
100059821  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100058456  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
100062573  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
100064604  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
100049903  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
100051468  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
100053987  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
100059081  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
100057015  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X2 [KO:K03032]
100147612  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
100058668  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
100063689  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
100071770  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100055920  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
100067363  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
100050948  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
100216429  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
100051409  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X2 [KO:K03030]
100064192  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102150324  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
100062208  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
100051482  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
100063286  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
100034153  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
100054206  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100066794  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
100063330  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
100068539  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
100057794  ATXN2; ataxin-2 isoform X1 [KO:K23625]
100066373  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
100062181  MATR3; matrin-3 [KO:K13213]
100034041  ANG; angiogenin precursor [KO:K16631] [EC:3.1.27.-]
100064523  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
106782613  ALYREF; THO complex subunit 4 [KO:K12881]
100053336  serine/arginine-rich splicing factor 3 [KO:K12892]
100053744  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
100054033  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
100049009  NXF1; nuclear RNA export factor 1 isoform 2 [KO:K14284]
100060240  nuclear RNA export factor 3 [KO:K14284]
100060140  nuclear RNA export factor 3 isoform X2 [KO:K14284]
100060201  nuclear RNA export factor 2 [KO:K14284]
100060857  LOW QUALITY PROTEIN: nuclear RNA export factor 2 [KO:K14284]
100067224  nuclear RNA export factor 3-like [KO:K14284]
111771475  nuclear RNA export factor 3-like [KO:K14284]
100059798  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
102149448  NXT1; NTF2-related export protein 1 [KO:K14285]
100066964  GLE1; nucleoporin GLE1 [KO:K18723]
100049850  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
100051494  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
100066078  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
100052986  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X2 [KO:K14297]
100050441  RAE1; mRNA export factor [KO:K14298]
100057913  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
100630847  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
100065427  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
100059287  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
100053164  NUP37; nucleoporin Nup37 [KO:K14302]
100058528  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
100052049  NUP85; nuclear pore complex protein Nup85 isoform X2 [KO:K14304]
100064615  NUP43; nucleoporin Nup43 [KO:K14305]
100056315  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
100060548  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
100059114  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
100051138  NUP54; nucleoporin p54 isoform X2 [KO:K14308]
100051892  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
100064995  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
100070114  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
100053405  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
100054143  NUP35; nucleoporin NUP53 [KO:K14313]
100055192  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
100056659  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X6 [KO:K14314]
100050513  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
100064071  POM121L2; POM121-like protein 2 [KO:K14316]
100061320  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
111774246  nuclear envelope pore membrane protein POM 121C-like [KO:K14316]
100069634  NUP214; LOW QUALITY PROTEIN: nuclear pore complex protein Nup214 [KO:K14317]
111767496  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
100061117  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
100060826  E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
100066679  SETX; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
100629759  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
100067235  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
100056253  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
111773414  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
100053417  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100064339  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100059209  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
100068006  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
100073186  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100069290  caspase-12 isoform X1 [KO:K04741] [EC:3.4.22.-]
100066488  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
100052709  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100053019  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100068507  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
100033834  TNF; tumor necrosis factor [KO:K03156]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100055840  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X3 [KO:K05141]
100146901  DAXX; death domain-associated protein 6 [KO:K02308]
100053481  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100053056  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100056278  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100056239  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100063532  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106782258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100051079  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100052693  CCS; copper chaperone for superoxide dismutase [KO:K04569]
100033835  GPX3; glutathione peroxidase 3 precursor [KO:K00432] [EC:1.11.1.9]
100034079  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
100050590  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
100146145  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
100053396  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
100061078  GPX6; glutathione peroxidase 6 precursor [KO:K00432] [EC:1.11.1.9]
100052064  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
102150050  glutathione peroxidase 1-like [KO:K00432] [EC:1.11.1.9]
100060647  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
100059208  PRPH; peripherin isoform X2 [KO:K07607]
100054178  NEFL; neurofilament light polypeptide [KO:K04572]
100054129  NEFM; neurofilament medium polypeptide [KO:K04573]
100064328  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
100146754  PFN3; profilin-3 [KO:K05759]
100061295  PFN1; profilin-1 [KO:K05759]
100056163  PFN4; profilin-4 isoform X1 [KO:K05759]
100630364  PFN2; profilin-2 isoform X1 [KO:K05759]
102148861  profilin-1 [KO:K05759]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100072856  ANXA7; annexin A7 isoform X2 [KO:K17095]
100064425  ANXA11; annexin A11 [KO:K17095]
100061228  KIF5B; kinesin-1 heavy chain [KO:K10396]
100050542  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100056413  KIF5C; kinesin heavy chain isoform X1 [KO:K10396]
100055017  KLC4; kinesin light chain 4 [KO:K10407]
100055290  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
100147291  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
100052297  KLC2; kinesin light chain 2 [KO:K10407]
100059285  tubulin alpha-1D chain [KO:K07374]
100051840  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100051901  tubulin alpha-1C chain [KO:K07374]
100052388  tubulin alpha-3 chain [KO:K07374]
100054576  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
100065732  tubulin alpha-3 chain [KO:K07374]
100059249  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100146855  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100059091  tubulin alpha-1B chain [KO:K07374]
100072403  tubulin alpha-3 chain [KO:K07374]
100050361  tubulin beta-2B chain [KO:K07375]
100056684  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
100051013  TUBB; tubulin beta chain [KO:K07375]
100058421  TUBB6; tubulin beta-6 chain [KO:K07375]
100629875  TUBB2A; tubulin beta-2A chain [KO:K07375]
100059595  TUBB4B; tubulin beta-4B chain [KO:K07375]
100065776  TUBB4A; tubulin beta-4A chain [KO:K07375]
111772826  TUBB3; tubulin beta-3 chain [KO:K07375]
100053938  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
100050464  DCTN2; dynactin subunit 2 isoform X3 [KO:K10424]
100068546  DCTN3; dynactin subunit 3 isoform X2 [KO:K10425]
100071625  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
100068373  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
100058409  DCTN6; dynactin subunit 6 [KO:K10428]
100069908  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
100051108  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100058966  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
100066559  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
100060282  DNAH1; dynein heavy chain 1, axonemal isoform X2 [KO:K10408]
100146115  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
100059138  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
100070297  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
100070308  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
100067558  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
100073091  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
100050892  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
100065248  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
100061177  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
100057640  DNAH17; dynein heavy chain 17, axonemal isoform X1 [KO:K10408]
100056953  DNAH14; dynein heavy chain 14, axonemal isoform X1 [KO:K10408]
102150627  DNAH11; dynein heavy chain 11, axonemal isoform X1 [KO:K10408]
100069142  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
100068649  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
100060918  DNAI2; dynein intermediate chain 2, axonemal isoform X1 [KO:K11143]
100050368  DNAL1; dynein light chain 1, axonemal [KO:K10411]
100070185  DNAL4; dynein light chain 4, axonemal [KO:K10412]
100067133  SLC1A2; excitatory amino acid transporter 2 isoform X4 [KO:K05613]
791246  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100060020  GRIA1; glutamate receptor 1 isoform X4 [KO:K05197]
100069331  GRIA2; glutamate receptor 2 isoform 1 precursor [KO:K05198]
100059861  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100051329  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100063746  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100052410  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102148904  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100061417  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X4 [KO:K05455]
100072444  NRG2; LOW QUALITY PROTEIN: pro-neuregulin-2, membrane-bound isoform [KO:K05456]
100065480  NRG3; pro-neuregulin-3, membrane-bound isoform [KO:K05457]
100630158  NRG4; pro-neuregulin-4, membrane-bound isoform isoform X1 [KO:K05458]
100050182  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X6 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Related
pathway
ecb00190  Oxidative phosphorylation
ecb03013  Nucleocytoplasmic transport
ecb03050  Proteasome
ecb04010  MAPK signaling pathway
ecb04012  ErbB signaling pathway
ecb04020  Calcium signaling pathway
ecb04115  p53 signaling pathway
ecb04137  Mitophagy - animal
ecb04140  Autophagy - animal
ecb04141  Protein processing in endoplasmic reticulum
ecb04210  Apoptosis
ecb04724  Glutamatergic synapse
ecb04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

DBGET integrated database retrieval system