KEGG   PATHWAY: mmyo05022
Entry
mmyo05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Myotis myotis (greater mouse-eared bat)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mmyo05022  Pathways of neurodegeneration - multiple diseases
mmyo05022

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118677629  amyloid-beta precursor protein isoform X1 [KO:K04520]
118671627  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
118671448  SNCA; alpha-synuclein isoform X1 [KO:K04528]
118675854  TAR DNA-binding protein 43 isoform X1 [KO:K23600]
118656085  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
118674974  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
118678322  ATXN2; ataxin-2 isoform X1 [KO:K23625]
118652882  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
118666002  HTT; huntingtin isoform X1 [KO:K04533]
118674647  ATXN1L; ataxin-1-like [KO:K23616]
118676358  ATXN1; ataxin-1 [KO:K23616]
118659505  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
118662646  major prion protein [KO:K05634]
118649078  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
118678958  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
118649380  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
118665243  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
118660637  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
118664538  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
118667437  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118660195  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
118649794  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663015  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
118663147  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
118665361  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118662889  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118671569  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
118655815  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
118660957  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118658978  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
118667369  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
118668410  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118652119  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118679657  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118674213  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
118678796  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
118674511  RYR3; ryanodine receptor 3 [KO:K04963]
118663300  PDYN; proenkephalin-B [KO:K15840]
118672039  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
118655320  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
118656558  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118652139  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
118672228  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
118657505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
118658054  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
118659034  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
118654168  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
118664389  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
118655312  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118652154  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118667975  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
118654729  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
118678862  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
118655845  STX1A; syntaxin-1A [KO:K04560]
118679245  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
118678179  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
118652876  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118672007  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
118657710  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
118678803  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
118670813  DERL1; derlin-1 [KO:K11519]
118667356  transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
118665501  ubiquitin-like [KO:K02927]
118651897  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
118667612  ubiquitin [KO:K02927]
118664569  ubiquitin-like [KO:K02927]
118657591  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
118668681  ubiquitin-like [KO:K02977]
118668994  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
118654665  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118656810  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
118666406  polyubiquitin [KO:K04551]
118677213  polyubiquitin-like [KO:K04551]
118655509  UBC; polyubiquitin-C isoform X1 [KO:K08770]
118677907  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
118667652  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
118665958  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
118674683  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
118679096  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
118663715  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
118663798  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
118672988  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
118676281  LOW QUALITY PROTEIN: proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
118664860  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
118656008  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
118672366  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
118677495  proteasome subunit beta type-7-like [KO:K02739] [EC:3.4.25.1]
118667070  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
118672116  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
118675960  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
118679231  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
118659722  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
118673515  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
118666031  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
118659186  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
118674451  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
118655396  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
118665053  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
118671610  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
118676255  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 isoform X1 [KO:K03028]
118662263  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
118671666  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
118678430  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
118649948  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
118671823  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
118671770  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
118667921  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
118674324  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
118656347  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 7-like [KO:K03038]
118648967  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
118673745  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
118662250  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
118674093  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
118663710  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
118665674  SEM1; LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
118668091  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
118653252  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
118668468  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
118678206  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
118655696  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
118665012  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
118655572  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
118659985  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
118676380  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
118660677  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
118671998  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
118666448  GPR37; prosaposin receptor GPR37 [KO:K04243]
118678371  SEPTIN5; septin-5 isoform X1 [KO:K04557]
118656960  synphilin-1 isoform X1 [KO:K04558]
118667058  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
118662737  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
118672678  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
118649620  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118678214  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
118671592  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
118655263  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
118659758  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118659182  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118657754  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118652068  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
118679322  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118670993  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118664384  caspase-12-like isoform X1 [KO:K04741] [EC:3.4.22.-]
118674387  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
118675238  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
118656765  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
118649462  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
118666845  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
118657033  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
118677738  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
26889517  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
26889520  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26889529  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26889508  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26889530  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26889533  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26889510  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
118665210  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
118663528  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
118676864  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
118658680  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118653714  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118653841  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118659276  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
118651524  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
118666177  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
118659978  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
118666453  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
118674353  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
118651854  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
118659198  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
118667132  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
118650282  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
118677633  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial-like [KO:K03953]
118661392  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
118656414  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
118658957  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
118651305  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
118658191  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
118659585  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
118666341  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
118661238  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
118676920  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118676944  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
118667403  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
118652705  NDUFB7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
118669847  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
118670981  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
118656353  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
118653795  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
118661169  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
118672885  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
118665049  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
118656177  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
118656173  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
118658662  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
118665205  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
118659095  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
118664595  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
118655921  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
118670565  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
118676311  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
118672944  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
118664349  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
118674548  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
26889534  CYTB; cytochrome b [KO:K00412]
118658381  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
118653082  cytochrome c1, heme protein, mitochondrial [KO:K00413]
118676147  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
118668510  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
118656194  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
118677282  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
118658665  cytochrome b-c1 complex subunit 7-like [KO:K00417]
118670644  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
118658647  cytochrome b-c1 complex subunit 8 [KO:K00418]
118678367  cytochrome b-c1 complex subunit 9 [KO:K00419]
118678145  cytochrome b-c1 complex subunit 10-like [KO:K00420]
118658907  cytochrome b-c1 complex subunit 10 [KO:K00420]
26889505  COX3; cytochrome c oxidase subunit III [KO:K02262]
26889525  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26889527  COX2; cytochrome c oxidase subunit II [KO:K02261]
118674112  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
118663651  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
118675843  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
118676017  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
118652480  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
118678114  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
118656385  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
118657409  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
118666421  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118669352  cytochrome c oxidase subunit 6B1-like [KO:K02267]
118655199  cytochrome c oxidase subunit 6B2 [KO:K02267]
118674654  cytochrome c oxidase subunit 6B1 [KO:K02267]
118670671  cytochrome c oxidase subunit 6C [KO:K02268]
118671315  cytochrome c oxidase subunit 6C-like [KO:K02268]
118674194  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
118660137  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
118669062  uncharacterized protein LOC118669062 isoform X1 [KO:K02270]
118651610  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
118654460  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
118656735  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
118665381  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
118662999  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
118650906  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
118672118  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
118649386  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
118659348  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
118662963  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
118672074  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
26889504  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
118672708  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
118651236  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
118657855  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
118661898  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
118663441  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
118670790  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
118671931  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
118665670  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118671446  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
118676997  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
118655681  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
118675387  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
26889528  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
118663765  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118658112  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118673109  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
118674270  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
118654015  LOW QUALITY PROTEIN: mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
118670134  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
118665751  calmodulin-alpha-like isoform X1 [KO:K02183]
118677428  calmodulin-like [KO:K02183]
118658241  neo-calmodulin-like [KO:K02183]
118659208  CALM1; calmodulin-1 [KO:K02183]
118652797  CALM3; calmodulin-3 [KO:K02183]
118669030  CALM2; calmodulin-2 [KO:K02183]
118654466  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
118655601  CALML6; calmodulin-like protein 6 [KO:K02183]
118664770  calmodulin-like protein 5 [KO:K02183]
118672571  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
118658346  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118670147  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118671846  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118667234  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118668920  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
118665363  BAD; bcl2-associated agonist of cell death [KO:K02158]
118673639  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118669989  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118665178  FADD; FAS-associated death domain protein [KO:K02373]
118661495  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118652071  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118655437  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118679638  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118649737  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
118668824  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
118656436  TRAP1; heat shock protein 75 kDa, mitochondrial isoform X1 [KO:K09488]
118670177  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
118650915  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118650249  ADP/ATP translocase 2-like [KO:K05863]
118651243  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118665676  ADP/ATP translocase 3-like [KO:K05863]
118659237  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118652084  ADP/ATP translocase 2-like [KO:K05863]
118654152  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118657293  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118670193  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
118666111  cytochrome c [KO:K08738]
118679308  cytochrome c-like [KO:K08738]
118654943  cytochrome c-like [KO:K08738]
118650180  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
118677148  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118650210  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118656112  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
118676925  IFT57; intraflagellar transport protein 57 homolog isoform X1 [KO:K04638]
118659315  3-hydroxyacyl-CoA dehydrogenase type-2-like [KO:K08683] [EC:1.1.1.35 1.1.1.178]
118653717  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
118657806  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
118676714  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
118663066  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
118676152  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
118675233  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
118677446  OPTN; optineurin isoform X1 [KO:K19946]
118658615  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
118674235  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
118662561  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
118651925  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
118661088  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
118656083  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
118649395  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
118667610  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
118652600  RAB8A; ras-related protein Rab-8A [KO:K07901]
118654697  RAB39B; ras-related protein Rab-39B [KO:K07925]
118668936  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
118675322  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118653012  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
118649389  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
118651135  ATG101; autophagy-related protein 101 isoform X1 [KO:K19730]
118665077  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
118670959  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
118665082  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
118678960  beclin-2-like [KO:K08334]
118671466  BECN1; beclin-1 isoform X1 [KO:K08334]
118676302  beclin-2-like [KO:K08334]
118668185  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
118655744  ATG14; beclin 1-associated autophagy-related key regulator isoform X1 [KO:K17889]
118670051  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
118662908  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
118660375  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
118665340  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
118657857  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
118667386  LOW QUALITY PROTEIN: WD repeat domain phosphoinositide-interacting protein 2-like [KO:K17908]
118671561  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
118657663  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
118661151  ALS2; alsin isoform X1 [KO:K04575]
118668224  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
118657696  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
118675378  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
118660230  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
118651090  SPG11; spatacsin isoform X1 [KO:K19026]
118679652  tumor necrosis factor-like isoform X1 [KO:K03156]
118649937  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
118676259  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
118679513  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
118662418  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
118672023  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118660246  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118660247  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118657384  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118678505  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
118665249  CCS; copper chaperone for superoxide dismutase [KO:K04569]
118658304  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
118659650  epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
118668481  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
118675203  GPX7; glutathione peroxidase 7 isoform X1 [KO:K00432] [EC:1.11.1.9]
118656502  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
118656959  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
118665148  CAT; catalase isoform X1 [KO:K03781] [EC:1.11.1.6]
118651724  PRPH; peripherin isoform X1 [KO:K07607]
118659211  NEFL; neurofilament light polypeptide [KO:K04572]
118659329  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
118678250  NEFH; neurofilament heavy polypeptide [KO:K04574]
118650010  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
118661865  KIF5C; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
118676723  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
118674327  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
118660065  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
118655023  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
118665266  KLC2; kinesin light chain 2 [KO:K10407]
118650258  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
118650856  tubulin alpha-1B chain-like [KO:K07374]
118666216  tubulin alpha-1C chain-like [KO:K07374]
118673521  tubulin alpha-1B chain-like [KO:K07374]
118678375  LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
118678448  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
118652035  tubulin alpha-1A chain [KO:K07374]
118661080  TUBA4A; tubulin alpha-4A chain [KO:K07374]
118661627  tubulin alpha-1D chain isoform X1 [KO:K07374]
118672614  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
118658764  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
118679650  TUBB; tubulin beta chain [KO:K07375]
118652991  TUBB3; tubulin beta-3 chain [KO:K07375]
118655285  TUBB4B; tubulin beta-4B chain [KO:K07375]
118662962  TUBB1; tubulin beta-1 chain [KO:K07375]
118663023  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
118675862  tubulin beta-2B chain isoform X1 [KO:K07375]
118676275  TUBB2B; tubulin beta-2B chain [KO:K07375]
118675932  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118674082  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
118663040  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
118676987  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
118679647  CSNK2B; casein kinase II subunit beta [KO:K03115]
118664943  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
118668831  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
118649618  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
118667370  DCTN3; dynactin subunit 3 [KO:K10425]
118658062  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
118656362  dynactin subunit 5-like [KO:K10427]
118656415  DCTN5; dynactin subunit 5 [KO:K10427]
118650968  DCTN6; dynactin subunit 6 isoform X1 [KO:K10428]
118652468  ACTR1B; beta-centractin isoform X1 [KO:K16575]
118669799  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
118655966  ACTR10; actin-related protein 10 [KO:K16576]
118666136  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
118678956  DNAH14; dynein heavy chain 14, axonemal [KO:K10408]
118667959  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
118660645  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
118668589  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
118661241  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
118669351  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
118655492  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
118671176  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
118655944  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
118656373  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
118672094  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
118672427  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
118675844  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
118667712  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
118672215  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
118657832  DNAL1; dynein light chain 1, axonemal [KO:K10411]
118650153  DNAL4; dynein light chain 4, axonemal [KO:K10412]
118665863  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118658714  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118652970  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118670159  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118665322  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
118678942  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118671771  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
118679406  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
118669734  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
118673324  DKK2; dickkopf-related protein 2 [KO:K02165]
118670014  DKK1; dickkopf-related protein 1 [KO:K02165]
118650977  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118672911  WNT2B; protein Wnt-2b [KO:K00182]
118666478  WNT2; protein Wnt-2 [KO:K00182]
118658755  WNT3A; protein Wnt-3a isoform X1 [KO:K00312]
118672219  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
118676694  WNT4; protein Wnt-4 [KO:K00408]
118650248  WNT5B; protein Wnt-5b [KO:K00444]
118667971  WNT5A; protein Wnt-5a [KO:K00444]
118662211  WNT6; protein Wnt-6 [KO:K00445]
118650243  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118677354  WNT7A; protein Wnt-7a [KO:K00572]
118658912  WNT8A; protein Wnt-8a [KO:K00714]
118669850  WNT8B; protein Wnt-8b [KO:K00714]
118658374  WNT9A; protein Wnt-9a [KO:K01064]
118671436  WNT9B; protein Wnt-9b [KO:K01064]
118651671  WNT10B; protein Wnt-10b [KO:K01357]
118661959  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
118664619  WNT11; protein Wnt-11 [KO:K01384]
118666468  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118666245  FZD1; frizzled-1 [KO:K02432]
118661773  FZD7; frizzled-7 [KO:K02432]
118672294  FZD2; frizzled-2 [KO:K02235]
118658774  FZD3; frizzled-3 isoform X1 [KO:K02329]
118664546  FZD4; frizzled-4 [KO:K02354]
118661425  FZD5; frizzled-5 [KO:K02375]
118676314  FZD8; frizzled-8 [KO:K02375]
118670703  FZD6; frizzled-6 [KO:K02376]
118653033  FZD10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
118656623  FZD9; frizzled-9 [KO:K02842]
118649950  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
118665196  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
118650242  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
118677642  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118655561  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118672041  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118669908  FRAT1; proto-oncogene FRAT1 [KO:K03069]
118669907  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
118652848  AXIN1; axin-1 isoform X1 [KO:K02157]
118654322  LOW QUALITY PROTEIN: axin-1-like [KO:K02157]
118671617  AXIN2; axin-2 isoform X1 [KO:K04385]
118658707  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
118655759  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
118668371  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118657973  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
118665504  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118653594  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118654184  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118662055  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
118679606  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
118648965  HRAS; GTPase HRas isoform X1 [KO:K02833]
118649554  KRAS; GTPase KRas isoform X1 [KO:K07827]
118672986  NRAS; GTPase NRas [KO:K07828]
118653778  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118666337  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118668076  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118654213  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118657986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
118678650  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118656605  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
118653425  NOX1; NADPH oxidase 1 [KO:K08008]
118653335  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118664537  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118665292  RELA; transcription factor p65 [KO:K04735]
118671867  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118672123  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
118673371  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
118666134  IL6; interleukin-6 [KO:K05405]
118657543  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
118657544  IL1B; interleukin-1 beta [KO:K04519]
118672850  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
118676521  LOW QUALITY PROTEIN: ras-related protein Rab-8A-like [KO:K07901]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
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Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
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Reference
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Ross CA, Poirier MA
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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Reference
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  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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Reference
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  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
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  Authors
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  Title
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Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
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  Authors
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Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
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Int J Mol Sci 21:E3369 (2020)
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Reference
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  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
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Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Fullgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, Ricketts T, Schlotawa L, Vicinanza M, Won H, Zhu Y, Skidmore J, Rubinsztein DC
  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
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J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
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Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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Reference
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Axonal transport deficits and neurodegenerative diseases.
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Axonal transport and neurological disease.
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Reference
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Retrograde axonal transport: pathways to cell death?
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Related
pathway
mmyo00190  Oxidative phosphorylation
mmyo03050  Proteasome
mmyo04020  Calcium signaling pathway
mmyo04120  Ubiquitin mediated proteolysis
mmyo04137  Mitophagy - animal
mmyo04140  Autophagy - animal
mmyo04141  Protein processing in endoplasmic reticulum
mmyo04142  Lysosome
mmyo04210  Apoptosis
mmyo04310  Wnt signaling pathway
mmyo04724  Glutamatergic synapse
mmyo04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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