KEGG   ORTHOLOGY: K05355
Entry
K05355                      KO                                     
Symbol
hexPS, COQ1
Name
hexaprenyl diphosphate synthase [EC:2.5.1.82 2.5.1.83]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09245  (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
R09246  geranylgeranyl-diphosphate:isopentenyl-diphosphate transferase (adding 2 isopentenyl units)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K05355  hexPS, COQ1; hexaprenyl diphosphate synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K05355  hexPS, COQ1; hexaprenyl diphosphate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.82  hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
     K05355  hexPS, COQ1; hexaprenyl diphosphate synthase
    2.5.1.83  hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
     K05355  hexPS, COQ1; hexaprenyl diphosphate synthase
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K05355  hexPS, COQ1; hexaprenyl diphosphate synthase
Other DBs
COG: COG0142
Genes
CME: CYME_CMJ246C
SCE: YBR003W(COQ1)
SEUB: DI49_0184
SPAO: SPAR_B01070
AGO: AGOS_AER004W
ERC: Ecym_5300
KLA: KLLA0_E17183g
KMX: KLMA_60114(COQ1)
LTH: KLTH0G16368g
VPO: Kpol_1036p41
ZRO: ZYRO0A04620g
CGR: 2886824(GVI51_C04037)
NCS: NCAS_0I01970(NCAS0I01970)
NDI: NDAI_0A06570(NDAI0A06570)
TPF: TPHA_0A04460(TPHA0A04460)
TBL: TBLA_0F00560(TBLA0F00560)
TGB: HG536_0G03050
TDL: TDEL_0D04200(TDEL0D04200)
KAF: KAFR_0F02550(KAFR0F02550)
KNG: KNAG_0J01180(KNAG0J01180)
ZMK: HG535_0C02340
SLUD: SCDLUD_002533
DHA: DEHA2B02640g
PIC: PICST_86778(COQ1)
PGU: PGUG_02562
SPAA: SPAPADRAFT_59987
LEL: PVL30_000484(COQ1)
LBG: 92205789(LODBEIA_P05930)
CAL: CAALFM_CR00570WA(CaO19.7478)
CTP: CTRG_01016
COT: CORT_0A03790
CDU: CD36_25670
CTEN: 18246326(COQ1)
CLU: CLUG_04350
CLUS: A9F13_04g01595
CAUR: CJI96_0003402
ASAU: 88172993(PUMCH_001928)
PPA: PAS_chr4_0819
PKZ: C5L36_0D01990
BNN: FOA43_001379
BBRX: BRETT_002538
OPA: HPODL_03901
YLI: 2909963(YALI2_B00439g)
SLB: AWJ20_394(COQ1)
NCR: NCU02305
NTE: NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
SMP: 10801768(SMAC4_08723)
PAN: PODANSg1807
PBEL: QC761_509670(COQ1)
PPSD: QC762_509670(COQ1)
PPSP: QC763_509670(COQ1)
PPSA: QC764_509670(COQ1)
TTT: THITE_2117141
MTM: MYCTH_2308814
CTHR: CTHT_0016730
RTHE: 98124138(VTJ83DRAFT_3148)
MGR: MGG_03343
PPEI: PpBr36_06486
PGRI: PgNI_00709
SSCK: SPSK_04068
FGR: FGSG_10933
FPU: FPSE_06046
FPOA: FPOAC1_009679
FVN: FVRRES_10316
FVR: FVEG_11617
FOX: FOXG_12870
NHE: NECHADRAFT_93238
FFC: NCS54_00645700
FKR: NCS57_00686000
FMU: J7337_010022
TRE: TRIREDRAFT_68728
TRR: M419DRAFT_38563
TATV: 25779678(TrAtP1_008741)
TASP: 36617842(TrAFT101_002694)
MAJ: MAA_03330
MBRN: 26246070(G6M90_00g085240)
PCHM: VFPPC_04198
CMT: CCM_00496
AMUS: LMH87_000769
PLJ: 28884193(PLICBS_005461)
PTKZ: JDV02_003904(COQ1)
VAL: VDBG_03289
VDA: VDAG_02194
CFJ: CFIO01_07326
CLUP: CLUP02_12999
CHIG: CH63R_12248
CDET: 87947006(CDEST_10504)
SAPO: SAPIO_CDS3842
ELA: UCREL1_11765
PFY: PFICI_14449
SSL: SS1G_11088
BFU: BCIN_02g05540(Bccoq1)
MBE: MBM_07123
PSCO: LY89DRAFT_649566
GLZ: GLAREA_07665
ANI: ANIA_10340
AFM: AFUA_3G06120
ACT: ACLA_034080
NFI: NFIA_071130
AOR: AO090020000085
ANG: An11g10370
AFV: AFLA_010570
ALUC: AKAW2_80893A(COQ1)
ACHE: ACHE_70473A(COQ1)
APUU: APUU_31174S(COQ1)
PCS: N7525_009212
PDP: PDIP_00870
POU: POX_g09019
TMF: EYB26_009001
TRG: TRUGW13939_11219
CIM: CIMG_00484
CPW: 9691985(COQ1)
URE: UREG_00522
ABE: ARB_07252
TVE: TRV_03960
PBL: PAAG_05961
AJE: HCAG_01245
BGH: BDBG_06739
PNO: SNOG_03045
PTE: PTT_13690
PTRR: 6338962(PtrM4_028830)
BZE: COCCADRAFT_107085
BSC: COCSADRAFT_169302
BOR: COCMIDRAFT_22591
AALT: CC77DRAFT_951220
ADAC: 96087831(ACET3X_007509)
ARAB: EKO05_0000542
ZTR: MYCGRDRAFT_73426(COQ1)
PFJ: MYCFIDRAFT_72669
FFU: CLAFUR5_09538
CBET: CB0940_10267
BCOM: BAUCODRAFT_34812
NPA: UCRNP2_7312
TML: GSTUM_00003780001
SPO: 2541402(dps1)
SOM: SOMG_02290(dps1)
CNE: CNI01740
CNB: CNBH1650
CNG: CNAG_04375
CGI: CGB_H2490W
CDEU: CNBG_2676
CDEC: 89992801(IAS62_006032)
CTEG: 91991559(I308_104703)
CBAS: 91986370(I312_106327)
CDEP: 91090354(L203_106146)
KMG: 30163645(I203_102858)
KNE: 92182342(IAR55_005084)
KDJ: 28970842(I303_108533)
KBI: 30212437(I302_108900)
KPIN: 30174290(I206_107588)
KSH: 87958903(IL334_006773)
KER: 91101081(V865_002277)
TMS: TREMEDRAFT_15595
CCAC: CcaHIS019_0305350(COQ1)
PPL: POSPLDRAFT_90841
TVS: TRAVEDRAFT_157916
DSQ: DICSQDRAFT_173926 DICSQDRAFT_176811
PCO: PHACADRAFT_168921
SHS: STEHIDRAFT_71092
HIR: HETIRDRAFT_308186
PSQ: PUNSTDRAFT_25993
ADL: AURDEDRAFT_110102
FME: FOMMEDRAFT_136957
GTR: GLOTRDRAFT_67486
LBC: LACBIDRAFT_251291 LACBIDRAFT_335947
CCI: CC1G_00492 CC1G_05865
ABP: AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
PCUB: JR316_0011391
MPR: MPER_08383
MRR: Moror_7207 Moror_8053
MORE: E1B28_001638 E1B28_004206
SCM: SCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)
CPUT: CONPUDRAFT_116134
SLA: SERLADRAFT_444711
WSE: WALSEDRAFT_59360
WIC: J056_004047
UMA: UMAG_11674
PFP: PFL1_02050
SGRA: EX895_004282
MGL: MGL_1241
MRT: MRET_2902
MSYM: MSY001_0654
PGR: PGTG_00683
PTRC: PtA15_13A363 PtA15_1A555 PtA15_1A569
PSTR: Pst134EA_000298 Pst134EA_000303
MLR: MELLADRAFT_102532
RIE: OCT59_000539
DFA: DFA_03641(coq1)
PYO: PY17X_0301300
PCB: PCHAS_0303000
PBE: PBANKA_0300800
PKN: PKNH_0418400
PVX: PVX_003575
PCY: PCYB_042740
FCY: FRACYDRAFT_275453
PSOJ: PHYSODRAFT_336262
 » show all
Reference
PMID:2198286
  Authors
Ashby MN, Edwards PA
  Title
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
  Journal
J Biol Chem 265:13157-64 (1990)
  Sequence
[sce:YBR003W]
LinkDB

KEGG   ORTHOLOGY: K21274
Entry
K21274                      KO                                     
Symbol
hexs-a
Name
hexaprenyl diphosphate synthase small subunit [EC:2.5.1.83]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09245  (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K21274  hexs-a; hexaprenyl diphosphate synthase small subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K21274  hexs-a; hexaprenyl diphosphate synthase small subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.83  hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
     K21274  hexs-a; hexaprenyl diphosphate synthase small subunit
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K21274  hexs-a; hexaprenyl diphosphate synthase small subunit
Other DBs
GO: 0036423
Genes
MACR: BHM04_03485
MARY: LAU42_06000
MBRU: MGG13_06480
MEPI: KFV12_07720
MBOC: QSV55_06095
MPSH: QA539_05800
MCL: MCCL_1123(hepB1)
MCAK: MCCS_13100(hexs-a)
MBOE: HT586_07200
AG: BAA25266(hexs-a)
Reference
PMID:9515931
  Authors
Shimizu N, Koyama T, Ogura K
  Title
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
  Journal
J Bacteriol 180:1578-81 (1998)
DOI:10.1128/JB.180.6.1578-1581.1998
  Sequence
[ag:BAA25266]
LinkDB

KEGG   ORTHOLOGY: K21275
Entry
K21275                      KO                                     
Symbol
hexs-b
Name
hexaprenyl diphosphate synthase large subunit [EC:2.5.1.83]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09245  (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K21275  hexs-b; hexaprenyl diphosphate synthase large subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K21275  hexs-b; hexaprenyl diphosphate synthase large subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.83  hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
     K21275  hexs-b; hexaprenyl diphosphate synthase large subunit
Prenyltransferases [BR:ko01006]
 Terpene biosynthesis
  Prenyl diphosphate synthase
   K21275  hexs-b; hexaprenyl diphosphate synthase large subunit
Other DBs
COG: COG0142
GO: 0036423
Genes
MACR: BHM04_03495
MARY: LAU42_05990
MBRU: MGG13_06470
MEPI: KFV12_07710
MEQU: KFV11_06170
MBOC: QSV55_06085
MPSH: QA539_05790
MCL: MCCL_1121(hepB2)
MCAK: MCCS_13080(hexs-b)
MBOE: HT586_07190
AG: BAA25268(hexs-b)
 » show all
Reference
PMID:9515931
  Authors
Shimizu N, Koyama T, Ogura K
  Title
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
  Journal
J Bacteriol 180:1578-81 (1998)
DOI:10.1128/JB.180.6.1578-1581.1998
  Sequence
[ag:BAA25268]
LinkDB

KEGG   ENZYME: 2.5.1.83
Entry
EC 2.5.1.83                 Enzyme                                 
Name
hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific];
HexPS (ambiguous);
hexaprenyl pyrophosphate synthetase (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09245]
Reaction(KEGG)
R09245
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1].
History
EC 2.5.1.83 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.83
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl diphosphate synthase
K21274  hexaprenyl diphosphate synthase small subunit
K21275  hexaprenyl diphosphate synthase large subunit
Genes
CME: CYME_CMJ246C
SCE: YBR003W(COQ1)
SEUB: DI49_0184
SPAO: SPAR_B01070
AGO: AGOS_AER004W
ERC: Ecym_5300
KLA: KLLA0_E17183g
KMX: KLMA_60114(COQ1)
LTH: KLTH0G16368g
VPO: Kpol_1036p41
ZRO: ZYRO0A04620g
CGR: 2886824(GVI51_C04037)
NCS: NCAS_0I01970(NCAS0I01970)
NDI: NDAI_0A06570(NDAI0A06570)
TPF: TPHA_0A04460(TPHA0A04460)
TBL: TBLA_0F00560(TBLA0F00560)
TGB: HG536_0G03050
TDL: TDEL_0D04200(TDEL0D04200)
KAF: KAFR_0F02550(KAFR0F02550)
KNG: KNAG_0J01180(KNAG0J01180)
ZMK: HG535_0C02340
SLUD: SCDLUD_002533
DHA: DEHA2B02640g
PIC: PICST_86778(COQ1)
PGU: PGUG_02562
SPAA: SPAPADRAFT_59987
LEL: PVL30_000484(COQ1)
LBG: 92205789(LODBEIA_P05930)
CAL: CAALFM_CR00570WA(CaO19.7478)
CTP: CTRG_01016
COT: CORT_0A03790
CDU: CD36_25670
CTEN: 18246326(COQ1)
CLU: CLUG_04350
CLUS: A9F13_04g01595
CAUR: CJI96_0003402
ASAU: 88172993(PUMCH_001928)
PPA: PAS_chr4_0819
PKZ: C5L36_0D01990
BNN: FOA43_001379
BBRX: BRETT_002538
OPA: HPODL_03901
YLI: 2909963(YALI2_B00439g)
SLB: AWJ20_394(COQ1)
NCR: NCU02305
NTE: NEUTE1DRAFT124027(NEUTE1DRAFT_124027)
SMP: 10801768(SMAC4_08723)
PAN: PODANSg1807
PBEL: QC761_509670(COQ1)
PPSD: QC762_509670(COQ1)
PPSP: QC763_509670(COQ1)
PPSA: QC764_509670(COQ1)
TTT: THITE_2117141
MTM: MYCTH_2308814
CTHR: CTHT_0016730
RTHE: 98124138(VTJ83DRAFT_3148)
MGR: MGG_03343
PPEI: PpBr36_06486
PGRI: PgNI_00709
SSCK: SPSK_04068
FGR: FGSG_10933
FPU: FPSE_06046
FPOA: FPOAC1_009679
FVN: FVRRES_10316
FVR: FVEG_11617
FOX: FOXG_12870
NHE: NECHADRAFT_93238
FFC: NCS54_00645700
FKR: NCS57_00686000
FMU: J7337_010022
TRE: TRIREDRAFT_68728
TRR: M419DRAFT_38563
TATV: 25779678(TrAtP1_008741)
TASP: 36617842(TrAFT101_002694)
MAJ: MAA_03330
MBRN: 26246070(G6M90_00g085240)
PCHM: VFPPC_04198
CMT: CCM_00496
AMUS: LMH87_000769
PLJ: 28884193(PLICBS_005461)
PTKZ: JDV02_003904(COQ1)
VAL: VDBG_03289
VDA: VDAG_02194
CFJ: CFIO01_07326
CLUP: CLUP02_12999
CHIG: CH63R_12248
CDET: 87947006(CDEST_10504)
SAPO: SAPIO_CDS3842
ELA: UCREL1_11765
PFY: PFICI_14449
SSL: SS1G_11088
BFU: BCIN_02g05540(Bccoq1)
MBE: MBM_07123
PSCO: LY89DRAFT_649566
GLZ: GLAREA_07665
ANI: ANIA_10340
AFM: AFUA_3G06120
ACT: ACLA_034080
NFI: NFIA_071130
AOR: AO090020000085
ANG: An11g10370
AFV: AFLA_010570
ALUC: AKAW2_80893A(COQ1)
ACHE: ACHE_70473A(COQ1)
APUU: APUU_31174S(COQ1)
PCS: N7525_009212
PDP: PDIP_00870
POU: POX_g09019
TMF: EYB26_009001
TRG: TRUGW13939_11219
CIM: CIMG_00484
CPW: 9691985(COQ1)
URE: UREG_00522
ABE: ARB_07252
TVE: TRV_03960
PBL: PAAG_05961
AJE: HCAG_01245
BGH: BDBG_06739
PNO: SNOG_03045
PTE: PTT_13690
PTRR: 6338962(PtrM4_028830)
BZE: COCCADRAFT_107085
BSC: COCSADRAFT_169302
BOR: COCMIDRAFT_22591
AALT: CC77DRAFT_951220
ADAC: 96087831(ACET3X_007509)
ARAB: EKO05_0000542
ZTR: MYCGRDRAFT_73426(COQ1)
PFJ: MYCFIDRAFT_72669
FFU: CLAFUR5_09538
CBET: CB0940_10267
BCOM: BAUCODRAFT_34812
NPA: UCRNP2_7312
TML: GSTUM_00003780001
SPO: 2541402(dps1)
SOM: SOMG_02290(dps1)
CNE: CNI01740
CNB: CNBH1650
CNG: CNAG_04375
CGI: CGB_H2490W
CDEU: CNBG_2676
CDEC: 89992801(IAS62_006032)
CTEG: 91991559(I308_104703)
CBAS: 91986370(I312_106327)
CDEP: 91090354(L203_106146)
KMG: 30163645(I203_102858)
KNE: 92182342(IAR55_005084)
KDJ: 28970842(I303_108533)
KBI: 30212437(I302_108900)
KPIN: 30174290(I206_107588)
KSH: 87958903(IL334_006773)
KER: 91101081(V865_002277)
TMS: TREMEDRAFT_15595
CCAC: CcaHIS019_0305350(COQ1)
PPL: POSPLDRAFT_90841
TVS: TRAVEDRAFT_157916
DSQ: DICSQDRAFT_173926 DICSQDRAFT_176811
PCO: PHACADRAFT_168921
SHS: STEHIDRAFT_71092
HIR: HETIRDRAFT_308186
PSQ: PUNSTDRAFT_25993
ADL: AURDEDRAFT_110102
FME: FOMMEDRAFT_136957
GTR: GLOTRDRAFT_67486
LBC: LACBIDRAFT_251291 LACBIDRAFT_335947
CCI: CC1G_00492 CC1G_05865
ABP: AGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABV: AGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
PCUB: JR316_0011391
MPR: MPER_08383
MRR: Moror_7207 Moror_8053
MORE: E1B28_001638 E1B28_004206
SCM: SCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)
CPUT: CONPUDRAFT_116134
SLA: SERLADRAFT_444711
WSE: WALSEDRAFT_59360
WIC: J056_004047
UMA: UMAG_11674
PFP: PFL1_02050
SGRA: EX895_004282
MGL: MGL_1241
MRT: MRET_2902
MSYM: MSY001_0654
PGR: PGTG_00683
PTRC: PtA15_13A363 PtA15_1A555 PtA15_1A569
PSTR: Pst134EA_000298 Pst134EA_000303
MLR: MELLADRAFT_102532
RIE: OCT59_000539
DFA: DFA_03641(coq1)
PYO: PY17X_0301300
PCB: PCHAS_0303000
PBE: PBANKA_0300800
PKN: PKNH_0418400
PVX: PVX_003575
PCY: PCYB_042740
FCY: FRACYDRAFT_275453
PSOJ: PHYSODRAFT_336262
MACR: BHM04_03485 BHM04_03495
MARY: LAU42_05990 LAU42_06000
MBRU: MGG13_06470 MGG13_06480
MEPI: KFV12_07710 KFV12_07720
MEQU: KFV11_06170
MBOC: QSV55_06085 QSV55_06095
MPSH: QA539_05790 QA539_05800
MCL: MCCL_1121(hepB2) MCCL_1123(hepB1)
MCAK: MCCS_13080(hexs-b) MCCS_13100(hexs-a)
MBOE: HT586_07190 HT586_07200
 » show all
Reference
1  [PMID:7174655]
  Authors
Fujii H, Koyama T, Ogura K.
  Title
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.
  Journal
J Biol Chem 257:14610-2 (1982)
  Sequence
[ag:BAA25266 BAA25268]
Reference
2  [PMID:9515931]
  Authors
Shimizu N, Koyama T, Ogura K
  Title
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
  Journal
J Bacteriol 180:1578-81 (1998)
DOI:10.1128/JB.180.6.1578-1581.1998
  Sequence
[ag:BAA25266 BAA25268]
Reference
3  [PMID:11514159]
  Authors
Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T
  Title
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases.
  Journal
Bioorg Med Chem Lett 11:2157-9 (2001)
DOI:10.1016/S0960-894X(01)00391-2
  Sequence
[ag:BAA25266 BAA25268]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.83
IUBMB Enzyme Nomenclature: 2.5.1.83
ExPASy - ENZYME nomenclature database: 2.5.1.83
BRENDA, the Enzyme Database: 2.5.1.83
LinkDB

KEGG   REACTION: R09245
Entry
R09245                      Reaction                               
Name
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Definition
trans,trans-Farnesyl diphosphate + 3 Isopentenyl diphosphate <=> all-trans-Hexaprenyl diphosphate + 3 Diphosphate
Equation
C00448 + 3 C00129 <=> C01230 + 3 C00013
Comment
3-step reaction (see R02061+R07475+R05613)
Reaction class
RC00279  C00129_C01230
Enzyme
2.5.1.83
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.83
     R09245  trans,trans-Farnesyl diphosphate + 3 Isopentenyl diphosphate <=> all-trans-Hexaprenyl diphosphate + 3 Diphosphate
Orthology
K05355  hexaprenyl diphosphate synthase [EC:2.5.1.82 2.5.1.83]
K21274  hexaprenyl diphosphate synthase small subunit [EC:2.5.1.83]
K21275  hexaprenyl diphosphate synthase large subunit [EC:2.5.1.83]
Other DBs
RHEA: 27562
LinkDB

DBGET integrated database retrieval system