| Entry |
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| Name |
hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific];
HexPS (ambiguous);
hexaprenyl pyrophosphate synthetase (ambiguous);
hexaprenyl diphosphate synthase (ambiguous)
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
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| Reaction(IUBMB) |
(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate [RN: R09245]
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| Reaction(KEGG) |
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| Substrate |
(2E,6E)-farnesyl diphosphate [CPD: C00448];
isopentenyl diphosphate [CPD: C00129]
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| Product |
diphosphate [CPD: C00013];
all-trans-hexaprenyl diphosphate [CPD: C01230]
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| Comment |
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and dimethylallyl diphosphate [1].
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| History |
EC 2.5.1.83 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.83
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K05355 | hexaprenyl-diphosphate synthase |
| K21274 | hexaprenyl-diphosphate synthase small subunit |
| K21275 | hexaprenyl-diphosphate synthase large subunit |
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| Genes |
» show all
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| Reference |
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| Authors |
Fujii H, Koyama T, Ogura K. |
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| Title |
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components. |
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| Journal |
J Biol Chem 257:14610-2 (1982) |
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| Sequence |
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| Reference |
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| Authors |
Shimizu N, Koyama T, Ogura K |
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| Title |
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T |
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| Title |
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.83 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.83 |
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| LinkDB |
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