KEGG   ORTHOLOGY: K12800
Entry
K12800                      KO                                     

Name
NLRP3, PYPAF1
Definition
NACHT, LRR and PYD domains-containing protein 3
Pathway
map04217  Necroptosis
map04621  NOD-like receptor signaling pathway
map04625  C-type lectin receptor signaling pathway
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05164  Influenza A
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
Disease
H00282  Cryopyrin associated periodic syndrome
H01359  Anaphylaxis
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   04625 C-type lectin receptor signaling pathway
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   05164 Influenza A
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   05132 Salmonella infection
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   05131 Shigellosis
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   05135 Yersinia infection
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
   05133 Pertussis
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   TRIM-directed selective autophagy
    K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
Pattern recognition receptors [BR:ko04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
Genes
HSA: 114548(NLRP3)
PTR: 469743(NLRP3)
PPS: 100984425(NLRP3)
GGO: 101125506(NLRP3)
PON: 100462520(NLRP3)
NLE: 100601058(NLRP3)
MCC: 701278(NLRP3)
MCF: 102142532(NLRP3)
CSAB: 103230928(NLRP3)
CATY: 105599484(NLRP3)
PANU: 101007974(NLRP3)
RRO: 104681129(NLRP3)
RBB: 108544055(NLRP3)
TFN: 117074712(NLRP3)
PTEH: 111545191(NLRP3)
CJC: 100392399(NLRP3)
SBQ: 101032875(NLRP3)
MMUR: 105864247(NLRP3)
MMU: 216799(Nlrp3)
MCAL: 110305596(Nlrp3)
MPAH: 110332320(Nlrp3)
RNO: 287362(Nlrp3)
MCOC: 116078316(Nlrp3)
MUN: 110550006(Nlrp3)
CGE: 100759809(Nlrp3)
PLEU: 114683009(Nlrp3)
NGI: 103739968(Nlrp3)
HGL: 101712523(Nlrp3)
CCAN: 109687959(Nlrp3)
OCU: 100351623(NLRP3)
TUP: 102492932(NLRP3)
CFA: 490576(NLRP3)
VVP: 112909597(NLRP3)
AML: 100468792(NLRP3)
UMR: 103682420(NLRP3)
UAH: 113247462(NLRP3)
ORO: 101380612(NLRP3)
ELK: 111139817
MPUF: 101683072(NLRP3)
EJU: 114201982(NLRP3)
MLX: 118026897(NLRP3)
FCA: 101092579(NLRP3)
PTG: 102954761
PPAD: 109260338(NLRP3)
AJU: 106966765(NLRP3)
HHV: 120221401(NLRP3)
BTA: 538639(NLRP3)
BOM: 102286926(NLRP3)
BIU: 109561926(NLRP3)
BBUB: 102408947(NLRP3)
CHX: 102173382(NLRP3)
OAS: 101107699(NLRP3)
ODA: 120863798(NLRP3)
SSC: 100514823(NLRP3)
CFR: 102520415(NLRP3)
CDK: 105104203(NLRP3)
BACU: 103015934(NLRP3)
LVE: 103081962
OOR: 101282000(NLRP3)
DLE: 111166657(NLRP3)
PCAD: 102976103(NLRP3)
ECB: 100073322(NLRP3)
EPZ: 103565123
EAI: 106821825(NLRP3)
MYB: 102262302(NLRP3)
MYD: 102755091(NLRP3)
MMYO: 118658655(NLRP3)
MNA: 107529863(NLRP3)
HAI: 109377395(NLRP3)
DRO: 112305210(NLRP3)
SHON: 118981855(NLRP3)
AJM: 119051579(NLRP3)
PALE: 102881234(NLRP3)
RAY: 107500359(NLRP3)
MJV: 108405469(NLRP3)
TOD: 119235981(NLRP3)
LAV: 100669613(NLRP3)
TMU: 101343031
FPG: 101918175(NLRP6)
FCH: 102052794(NLRP6)
NNI: 104011420
ACUN: 113480957(NLRP6)
PADL: 103925463(NLRP6)
AAM: 106489120(NLRP6) 106495303
ASN: 102383266
CABI: 116822739
PMUA: 114600470(NLRP6)
ZVI: 118077475(NLRP6)
NPR: 108797721
HAME: 121878739
 » show all
Reference
  Authors
Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD
  Title
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.
  Journal
Nat Genet 29:301-5 (2001)
DOI:10.1038/ng756
  Sequence
[hsa:114548]
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