Entry |
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Name |
PPAR signaling pathway - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
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Description |
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
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Class |
Organismal Systems; Endocrine system
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Pathway map |

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Organism |
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN: sbq]
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Gene |
101037455 | SLC27A4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-] |
101032922 | SLC27A1; long-chain fatty acid transport protein 1 isoform X1 [KO:K08745] [EC:6.2.1.-] |
101032215 | PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294] |
101031846 | PPARD; peroxisome proliferator-activated receptor delta [KO:K04504] |
101028278 | PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530] |
101034499 | ACADL; LOW QUALITY PROTEIN: long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8] |
101038807 | SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086] |
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Compound |
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Reference |
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Authors |
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T. |
Title |
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)] |
Journal |
Nippon Rinsho 63:557-64 (2005) |
Reference |
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Authors |
Fujii H. |
Title |
[PPARs-mediated intracellular signal transduction] |
Journal |
Nippon Rinsho 63:565-71 (2005) |
Reference |
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Authors |
Takada I, Kato S. |
Title |
[PPARs target genes] |
Journal |
Nippon Rinsho 63:573-7 (2005) |
Reference |
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Authors |
Inoue H. |
Title |
[Endogenous ligands for PPARs] |
Journal |
Nippon Rinsho 63:578-83 (2005) |
Reference |
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Authors |
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. |
Title |
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. |
Journal |
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Reference |
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Authors |
Desvergne B, Michalik L, Wahli W. |
Title |
Transcriptional regulation of metabolism. |
Journal |
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Reference |
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Authors |
Mandard S, Muller M, Kersten S. |
Title |
Peroxisome proliferator-activated receptor alpha target genes. |
Journal |
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Reference |
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Authors |
Desvergne B, Wahli W. |
Title |
Peroxisome proliferator-activated receptors: nuclear control of metabolism. |
Journal |
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Reference |
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Authors |
Savage DB. |
Title |
PPARgamma as a metabolic regulator: insights from genomics and pharmacology. |
Journal |
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Reference |
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Authors |
Semple RK, Chatterjee VK, O'Rahilly S. |
Title |
PPAR gamma and human metabolic disease. |
Journal |
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Reference |
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Authors |
Lehrke M, Lazar MA. |
Title |
The many faces of PPARgamma. |
Journal |
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Reference |
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Authors |
Hauner H. |
Title |
The mode of action of thiazolidinediones. |
Journal |
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Related pathway |
sbq00072 | Synthesis and degradation of ketone bodies |
sbq04920 | Adipocytokine signaling pathway |
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KO pathway |
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LinkDB |
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