KEGG   PATHWAY: shr03320
shr03320                    Pathway                                

PPAR signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Organismal Systems; Endocrine system
Pathway map
shr03320  PPAR signaling pathway

Sarcophilus harrisii (Tasmanian devil) [GN:shr]
100916220  CD36; platelet glycoprotein 4 [KO:K06259]
100924975  SLC27A4; long-chain fatty acid transport protein 4 isoform X1 [KO:K08745] [EC:6.2.1.-]
100929638  SLC27A1; long-chain fatty acid transport protein 1 isoform X1 [KO:K08745] [EC:6.2.1.-]
100933261  SLC27A2; very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.-]
100916639  SLC27A5; bile acyl-CoA synthetase [KO:K08748] [EC:]
100932753  FABP1; fatty acid-binding protein, liver [KO:K08750]
100916489  FABP2; fatty acid-binding protein, intestinal [KO:K08751]
100918463  FABP3; fatty acid-binding protein, heart [KO:K08752]
100921042  FABP4; fatty acid-binding protein, adipocyte [KO:K08753]
100920783  FABP9; fatty acid-binding protein 9 [KO:K08753]
100933267  FABP6; gastrotropin [KO:K08755]
100917000  FABP7; fatty acid-binding protein, brain [KO:K08756]
100917093  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
100926708  RXRA; retinoic acid receptor RXR-alpha isoform X3 [KO:K08524]
100914649  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100932014  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100920568  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
100934154  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100926626  HMGCS1; hydroxymethylglutaryl-CoA synthase, cytoplasmic [KO:K01641] [EC:]
100914059  HMGCS2; hydroxymethylglutaryl-CoA synthase, mitochondrial [KO:K01641] [EC:]
100928796  APOA1; apolipoprotein A-I [KO:K08757]
100917341  APOA2; apolipoprotein A-II [KO:K08758]
111719785  APOC3; apolipoprotein C-III [KO:K08759]
100931655  APOA5; apolipoprotein A-V [KO:K09025]
100934046  PLTP; phospholipid transfer protein [KO:K08761]
100927359  ME1; LOW QUALITY PROTEIN: NADP-dependent malic enzyme [KO:K00029] [EC:]
100920021  ME3; NADP-dependent malic enzyme, mitochondrial [KO:K00029] [EC:]
100930034  FADS2; acyl-CoA 6-desaturase [KO:K10226] [EC:]
100918255  SCD; acyl-CoA desaturase [KO:K00507] [EC:]
116419719  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:]
100926104  cytochrome P450 7A1 [KO:K00489] [EC:]
100926550  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase [KO:K07431] [EC:]
100919664  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:]
100918099  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:]
105749568  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:]
100916753  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
100918281  sterol 26-hydroxylase, mitochondrial [KO:K00488] [EC:]
100923587  DBI; acyl-CoA-binding protein [KO:K08762]
105749269  acyl-CoA-binding protein [KO:K08762]
116423461  diazepam-binding inhibitor-like 5 [KO:K08762]
100933361  LPL; lipoprotein lipase [KO:K01059] [EC:]
100920579  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:]
100920204  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:]
100929527  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:]
100932228  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X3 [KO:K01897] [EC:]
100931711  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:]
100922242  ACSBG1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:K15013] [EC:]
100928000  ACSBG2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X3 [KO:K15013] [EC:]
100928262  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X2 [KO:K15013] [EC:]
100913272  EHHADH; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:]
100924766  cytochrome P450 4A11-like [KO:K07425] [EC:]
100925023  LOW QUALITY PROTEIN: cytochrome P450 4A6-like [KO:K07425] [EC:]
100924239  cytochrome P450 4A6-like [KO:K07425] [EC:]
100932858  ACAA1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:]
100922562  SCP2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:]
100926515  LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:]
105750394  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:]
100926778  LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:]
100924634  ACOX2; peroxisomal acyl-coenzyme A oxidase 2 [KO:K10214] [EC:]
100931262  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:]
100930017  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:]
105749969  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:]
100921521  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:]
100927393  carnitine O-palmitoyltransferase 2, mitochondrial-like [KO:K08766] [EC:]
100921785  carnitine O-palmitoyltransferase 2, mitochondrial-like [KO:K08766] [EC:]
100914644  ACADL; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:]
100927873  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:]
100920877  ANGPTL4; angiopoietin-related protein 4 [KO:K08767]
100914931  SORBS1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
100924786  PLIN1; perilipin-1 isoform X1 [KO:K08768]
100916358  PLIN2; perilipin-2 isoform X1 [KO:K17284]
100920265  PLIN4; perilipin-4 isoform X2 [KO:K20254]
100920524  PLIN5; perilipin-5 [KO:K20255]
100924674  ADIPOQ; adiponectin [KO:K07296]
100915062  MMP1; interstitial collagenase [KO:K01388] [EC:]
100915068  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:]
100917568  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:]
100927720  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:]
100933453  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:]
100926292  GK; glycerol kinase isoform X1 [KO:K00864] [EC:]
100929016  glycerol kinase-like [KO:K00864] [EC:]
100930496  AQP7; aquaporin-7 isoform X1 [KO:K08771]
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
Nippon Rinsho 63:557-64 (2005)
Fujii H.
[PPARs-mediated intracellular signal transduction]
Nippon Rinsho 63:565-71 (2005)
Takada I, Kato S.
[PPARs target genes]
Nippon Rinsho 63:573-7 (2005)
Inoue H.
[Endogenous ligands for PPARs]
Nippon Rinsho 63:578-83 (2005)
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
Prog Lipid Res 45:120-59 (2006)
Desvergne B, Michalik L, Wahli W.
Transcriptional regulation of metabolism.
Physiol Rev 86:465-514 (2006)
Mandard S, Muller M, Kersten S.
Peroxisome proliferator-activated receptor alpha target genes.
Cell Mol Life Sci 61:393-416 (2004)
Desvergne B, Wahli W.
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Endocr Rev 20:649-88 (1999)
Savage DB.
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
Expert Rev Mol Med 2005:1-16 (2005)
Semple RK, Chatterjee VK, O'Rahilly S.
PPAR gamma and human metabolic disease.
J Clin Invest 116:581-9 (2006)
Lehrke M, Lazar MA.
The many faces of PPARgamma.
Cell 123:993-9 (2005)
Hauner H.
The mode of action of thiazolidinediones.
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
shr00071  Fatty acid degradation
shr00072  Synthesis and degradation of ketone bodies
shr00120  Primary bile acid biosynthesis
shr00564  Glycerophospholipid metabolism
shr04920  Adipocytokine signaling pathway
KO pathway

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