PATHWAY: slal04920
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Entry
slal04920 Pathway
Name
Adipocytokine signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin.
Leptin is an important regulator of energy intake and metabolic rate primarily by acting at hypothalamic nuclei. Leptin exerts its anorectic effects by modulating the levels of neuropeptides such as NPY, AGRP, and alpha-MSH. This leptin action is through the JAK kinase, STAT3 phosphorylation, and nuclear transcriptional effect.
Adiponectin lowers plasma glucose and FFAs. These effects are partly accounted for by adiponectin-induced AMPK activation, which in turn stimulates skeletal muscle fatty acid oxidation and glucose uptake. Furthermore, activation of AMPK by adiponectin suppresses endogenous glucose production, concomitantly with inhibition of PEPCK and G6Pase expression.
The proinflammatory cytokine TNFalpha has been implicated as a link between obesity and insulin resistance. TNFalpha interferes with early steps of insulin signaling. Several data have shown that TNFalpha inhibits IRS1 tyrosine phosphorylation by promoting its serine phosphorylation. Among the serine/threonine kinases activated by TNFalpha, JNK, mTOR and IKK have been shown to be involved in this phosphorylation.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
slal04920
Adipocytokine signaling pathway
Ortholog table
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:
slal
]
Gene
111645657
tumor necrosis factor-like [KO:
K03156
]
111655660
tumor necrosis factor-like isoform X1 [KO:
K03156
]
111669911
tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:
K03158
]
111666877
uncharacterized protein LOC111666877 [KO:
K03158
]
111646245
tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:
K03171
]
111657911
tumor necrosis factor receptor superfamily member 1B-like [KO:
K05141
]
111647918
TNF receptor-associated factor 2-like [KO:
K03173
] [EC:
2.3.2.27
]
111666015
TNF receptor-associated factor 2-like [KO:
K03173
] [EC:
2.3.2.27
]
111664872
TNF receptor-associated factor 2-like [KO:
K03173
] [EC:
2.3.2.27
]
111656119
mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:
K07203
] [EC:
2.7.11.1
]
111656807
mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:
K04440
] [EC:
2.7.11.24
]
111658196
mitogen-activated protein kinase 8-like isoform X1 [KO:
K04440
] [EC:
2.7.11.24
]
111664771
mitogen-activated protein kinase 8 [KO:
K04440
] [EC:
2.7.11.24
]
111646556
mitogen-activated protein kinase 9-like [KO:
K04440
] [EC:
2.7.11.24
]
111655428
inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:
K04467
] [EC:
2.7.11.10
]
111658207
inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:
K04467
] [EC:
2.7.11.10
]
111665990
ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:
K07209
] [EC:
2.7.11.10
]
111659926
ikbkg; NF-kappa-B essential modulator isoform X1 [KO:
K07210
]
111672507
NF-kappa-B inhibitor alpha-like [KO:
K04734
]
111673714
nfkbia; NF-kappa-B inhibitor alpha [KO:
K04734
]
111661549
nfkbie; NF-kappa-B inhibitor epsilon [KO:
K05872
]
111665614
LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:
K02580
]
111670446
rela; transcription factor p65 isoform X1 [KO:
K04735
]
111657717
socs3; suppressor of cytokine signaling 3 [KO:
K04696
]
111673508
suppressor of cytokine signaling 3-like [KO:
K04696
]
111665735
insulin receptor substrate 1-B-like [KO:
K16172
]
111646010
insulin receptor substrate 2-like [KO:
K07187
]
111665377
insulin receptor substrate 1-like [KO:
K07187
]
111667114
insulin receptor substrate 2-B-like [KO:
K07187
]
111662143
irs2; insulin receptor substrate 2 [KO:
K07187
]
111665447
RAC-beta serine/threonine-protein kinase [KO:
K04456
] [EC:
2.7.11.1
]
111659458
RAC-gamma serine/threonine-protein kinase-like [KO:
K04456
] [EC:
2.7.11.1
]
111673263
akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:
K04456
] [EC:
2.7.11.1
]
111653974
RAC-beta serine/threonine-protein kinase-like [KO:
K04456
] [EC:
2.7.11.1
]
111645313
RAC-gamma serine/threonine-protein kinase [KO:
K04456
] [EC:
2.7.11.1
]
111660053
cd36; platelet glycoprotein 4 [KO:
K06259
]
111657379
acsl6; long-chain-fatty-acid--CoA ligase 6 [KO:
K01897
] [EC:
6.2.1.3
]
111646477
long-chain-fatty-acid--CoA ligase 4-like [KO:
K01897
] [EC:
6.2.1.3
]
111662439
long-chain-fatty-acid--CoA ligase 4-like [KO:
K01897
] [EC:
6.2.1.3
]
111654481
long-chain-fatty-acid--CoA ligase 3-like [KO:
K01897
] [EC:
6.2.1.3
]
111667608
long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:
K01897
] [EC:
6.2.1.3
]
111663892
long-chain-fatty-acid--CoA ligase 1-like [KO:
K01897
] [EC:
6.2.1.3
]
111651836
long-chain-fatty-acid--CoA ligase 4-like [KO:
K01897
] [EC:
6.2.1.3
]
111656174
acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:
K01897
] [EC:
6.2.1.3
]
111653979
long-chain-fatty-acid--CoA ligase 4-like [KO:
K01897
] [EC:
6.2.1.3
]
111664013
long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:
K01897
] [EC:
6.2.1.3
]
111671267
acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:
K01897
] [EC:
6.2.1.3
]
111654910
long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:
K15013
] [EC:
6.2.1.3
]
111664226
long-chain-fatty-acid--CoA ligase ACSBG1-like [KO:
K15013
] [EC:
6.2.1.3
]
111645377
acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:
K15013
] [EC:
6.2.1.3
]
111666975
acsbg1; long-chain-fatty-acid--CoA ligase ACSBG1 isoform X1 [KO:
K15013
] [EC:
6.2.1.3
]
111661316
prkcq; protein kinase C theta type [KO:
K18052
] [EC:
2.7.11.13
]
111656484
leptin-B-like [KO:
K05424
]
111645375
lepr; leptin receptor isoform X1 [KO:
K05062
]
111665981
jak2; tyrosine-protein kinase JAK2 [KO:
K04447
] [EC:
2.7.10.2
]
111651535
tyrosine-protein kinase JAK2-like [KO:
K04447
] [EC:
2.7.10.2
]
111660433
stat3; signal transducer and activator of transcription 3 isoform X1 [KO:
K04692
]
111665689
pro-opiomelanocortin-like [KO:
K05228
]
111650570
pro-opiomelanocortin-like [KO:
K05228
]
111657888
pro-opiomelanocortin [KO:
K05228
]
111646907
pro-opiomelanocortin-like [KO:
K05228
]
111649950
5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:
K07198
] [EC:
2.7.11.11
]
111650214
serine/threonine protein kinase OSK1-like [KO:
K07198
] [EC:
2.7.11.11
]
111668062
prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:
K07198
] [EC:
2.7.11.11
]
111655957
5'-AMP-activated protein kinase subunit beta-1-like [KO:
K07199
]
111654804
5'-AMP-activated protein kinase subunit beta-2-like [KO:
K07199
]
111645026
5'-AMP-activated protein kinase subunit beta-1-like [KO:
K07199
]
111673153
5'-AMP-activated protein kinase subunit gamma-1-like [KO:
K07200
]
111647310
5'-AMP-activated protein kinase subunit gamma-1-like [KO:
K07200
]
111648137
5'-AMP-activated protein kinase subunit gamma-2-like [KO:
K07200
]
111667735
prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:
K07200
]
111670476
5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:
K07200
]
111644420
5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:
K07200
]
111649676
uncharacterized protein LOC111649676 isoform X1 [KO:
K05231
]
111652978
uncharacterized protein LOC111652978 isoform X1 [KO:
K05231
]
111667241
uncharacterized protein LOC111667241 isoform X1 [KO:
K05231
]
111661274
agouti-related protein-like [KO:
K05231
]
111666577
uncharacterized protein LOC111666577 isoform X1 [KO:
K05231
]
111670101
npy; pro-neuropeptide Y [KO:
K05232
]
111665947
ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:
K07202
]
111648212
phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:
K01596
] [EC:
4.1.1.32
]
111652122
pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:
K01596
] [EC:
4.1.1.32
]
111654531
g6pc2; glucose-6-phosphatase 2 [KO:
K01084
] [EC:
3.1.3.9
]
111656130
glucose-6-phosphatase-like [KO:
K01084
] [EC:
3.1.3.9
]
111656159
g6pc3; glucose-6-phosphatase 3 [KO:
K01084
] [EC:
3.1.3.9
]
111656166
g6pc; glucose-6-phosphatase [KO:
K01084
] [EC:
3.1.3.9
]
111666017
ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:
K07293
] [EC:
3.1.3.48
]
111656118
tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:
K07293
] [EC:
3.1.3.48
]
111650434
peroxisome proliferator-activated receptor alpha-like [KO:
K07294
]
111651966
ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:
K07294
]
111655951
rxra; retinoic acid receptor RXR-alpha [KO:
K08524
]
111661213
retinoic acid receptor RXR-beta-A isoform X1 [KO:
K08525
]
111656331
retinoic acid receptor RXR-gamma-B isoform X1 [KO:
K08526
]
111663680
adiponectin receptor protein 2-like [KO:
K07297
]
111667831
adipor1; adiponectin receptor protein 1 [KO:
K07297
]
111652612
stk11; serine/threonine-protein kinase STK11 [KO:
K07298
] [EC:
2.7.11.1
]
111652996
calcium/calmodulin-dependent protein kinase kinase 2-like isoform X1 [KO:
K07359
] [EC:
2.7.11.17
]
111660366
acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:
K01946
] [EC:
6.4.1.2
6.3.4.14
2.1.3.15
]
111658709
carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:
K08765
] [EC:
2.3.1.21
]
111671246
carnitine O-palmitoyltransferase 1, liver isoform-like [KO:
K08765
] [EC:
2.3.1.21
]
111662452
carnitine O-palmitoyltransferase 1, liver isoform-like [KO:
K08765
] [EC:
2.3.1.21
]
111661771
carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:
K08765
] [EC:
2.3.1.21
]
111657929
solute carrier family 2, facilitated glucose transporter member 1-like [KO:
K07299
]
111658845
solute carrier family 2, facilitated glucose transporter member 1-like [KO:
K07299
]
111646791
solute carrier family 2, facilitated glucose transporter member 1-like [KO:
K07299
]
111650692
slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:
K07191
]
Compound
C00040
Acyl-CoA
C00083
Malonyl-CoA
C00162
Fatty acid
C00165
Diacylglycerol
C00195
N-Acylsphingosine
C00638
Long-chain fatty acid
C15493
9-cis-Retinoic acid
Reference
PMID:
15733744
Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
Journal
Biochimie 87:99-109 (2005)
DOI:
10.1016/j.biochi.2004.10.019
Reference
PMID:
12829246
Authors
Hardie DG, Scott JW, Pan DA, Hudson ER.
Title
Management of cellular energy by the AMP-activated protein kinase system.
Journal
FEBS Lett 546:113-20 (2003)
DOI:
10.1016/S0014-5793(03)00560-X
Reference
PMID:
15980064
Authors
Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA.
Title
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.
Journal
J Biol Chem 280:29060-6 (2005)
DOI:
10.1074/jbc.M503824200
Reference
PMID:
10766253
Authors
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG.
Title
Central nervous system control of food intake.
Journal
Nature 404:661-71 (2000)
DOI:
10.1038/35007534
Reference
PMID:
15856064
Authors
Munzberg H, Myers MG Jr.
Title
Molecular and anatomical determinants of central leptin resistance.
Journal
Nat Neurosci 8:566-70 (2005)
DOI:
10.1038/nn1454
Reference
PMID:
12754525
Authors
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM.
Title
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Journal
Nature 423:550-5 (2003)
DOI:
10.1038/nature01667
Reference
PMID:
11557972
Authors
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM.
Title
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
Journal
Nature 413:131-8 (2001)
DOI:
10.1038/35093050
Reference
PMID:
14716305
Authors
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M.
Title
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.
Journal
Nat Med 10:168-74 (2004)
DOI:
10.1038/nm980
Reference
PMID:
9671776
Authors
Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH.
Title
Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
Journal
Proc Natl Acad Sci U S A 95:8898-903 (1998)
DOI:
10.1073/pnas.95.15.8898
Reference
PMID:
10905472
Authors
Kelley DE, Mandarino LJ.
Title
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
Journal
Diabetes 49:677-83 (2000)
DOI:
10.2337/diabetes.49.5.677
Reference
PMID:
12368907
Authors
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T.
Title
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Journal
Nat Med 8:1288-95 (2002)
DOI:
10.1038/nm788
Reference
PMID:
11479627
Authors
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T.
Title
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Journal
Nat Med 7:941-6 (2001)
DOI:
10.1038/90984
Reference
PMID:
15058305
Authors
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB.
Title
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Journal
Nature 428:569-74 (2004)
DOI:
10.1038/nature02440
Reference
PMID:
14679176
Authors
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr.
Title
Obesity is associated with macrophage accumulation in adipose tissue.
Journal
J Clin Invest 112:1796-808 (2003)
DOI:
10.1172/JCI19246
Related
pathway
slal04010
MAPK signaling pathway
slal04910
Insulin signaling pathway
KO pathway
ko04920
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