KEGG   PATHWAY: slal04910
Entry
slal04910                   Pathway                                
Name
Insulin signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
slal04910  Insulin signaling pathway
slal04910

Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111653396  ins; insulin [KO:K04526]
111672131  insulin-like [KO:K04526]
111664630  insulin-like [KO:K04526]
111669127  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111650192  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
111665735  insulin receptor substrate 1-B-like [KO:K16172]
111646010  insulin receptor substrate 2-like [KO:K07187]
111667114  insulin receptor substrate 2-B-like [KO:K07187]
111662143  irs2; insulin receptor substrate 2 [KO:K07187]
111651451  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111671089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111670553  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111671597  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111649932  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111666834  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111661265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111670636  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111671654  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111673607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111668884  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111658643  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111662131  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111649091  gys1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
111664253  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
111652244  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111665361  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
111670459  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111647878  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111661496  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111660545  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111651017  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111646301  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
111665491  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
111668625  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
111670704  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
111650413  protein phosphatase 1 regulatory subunit 3A-like [KO:K07189]
111655955  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
111649401  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
111649797  protein phosphatase 1 regulatory subunit 3B-like [KO:K07189]
111645021  protein phosphatase 1 regulatory subunit 3C-like [KO:K07189]
111651961  protein phosphatase 1 regulatory subunit 3B-like [KO:K07189]
111663615  uncharacterized protein LOC111663615 [KO:K07189]
111670145  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
111654182  ppp1r3f; protein phosphatase 1 regulatory subunit 3F isoform X1 [KO:K07189]
111650931  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
111658612  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
111651663  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
111672354  phkb; phosphorylase b kinase regulatory subunit beta [KO:K07190]
111667125  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
111655985  calmodulin [KO:K02183]
111653819  calml6; calmodulin-like protein 6 [KO:K02183]
111673711  calmodulin [KO:K02183]
111670884  calmodulin-like protein 4 [KO:K02183]
111670124  calml4; calmodulin-like protein 4 [KO:K02183]
111669508  calm2; calmodulin-2 [KO:K02183]
111672568  calmodulin isoform X1 [KO:K02183]
111666139  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
111646229  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
111665811  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
111667974  pygm; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
111654499  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
111653688  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111665555  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111658500  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111671991  prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
111667572  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
111670878  prkar2b; cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1 [KO:K04739]
111660824  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
111665114  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
111667225  cAMP-dependent protein kinase type I-alpha regulatory subunit-like isoform X1 [KO:K04739]
111657262  lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
111661080  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
111658840  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
111669154  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
111650692  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
111645596  flotillin-1 isoform X1 [KO:K07192]
111663896  flot2; flotillin-2 isoform X1 [KO:K07192]
111657963  flotillin-2-like [KO:K07192]
111669877  flotillin-1-like [KO:K07192]
111654118  SH2B adapter protein 2-like isoform X1 [KO:K07193]
111669502  sorbs1; sorbin and SH3 domain-containing protein 1 [KO:K06086]
111651622  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
111652625  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
111653975  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
111671297  adapter molecule crk-like [KO:K04438]
111655640  crkl; crk-like protein [KO:K04438]
111656071  adapter molecule crk-like [KO:K04438]
111668040  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111669465  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
111664353  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
111672963  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
111651484  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
111667550  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
111663862  acetyl-CoA carboxylase isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111660366  acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111664335  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
111648003  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
111645929  putative hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
111645930  hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
111665631  hexokinase-1-like isoform X1 [KO:K00844] [EC:2.7.1.1]
111656093  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
111654902  gck; glucokinase isoform X1 [KO:K12407] [EC:2.7.1.2]
111649950  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
111668062  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
111655957  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
111654804  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
111645026  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
111673153  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
111647310  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
111648137  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
111667735  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
111670476  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
111644420  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
111654758  LOW QUALITY PROTEIN: forkhead box protein O1-A-like [KO:K07201]
111666300  forkhead box protein O1-A-like [KO:K07201]
111665947  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
111654531  g6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
111656130  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
111656159  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
111656166  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
111666767  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
111660879  LOW QUALITY PROTEIN: fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
111660949  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
111648212  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
111652122  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
111656119  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111655458  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
111654555  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
111663925  rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111673584  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
111664076  rps6; 40S ribosomal protein S6 [KO:K02991]
111652867  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
111658248  eukaryotic translation initiation factor 4E-binding protein 1-like isoform X1 [KO:K07205]
111654676  eukaryotic translation initiation factor 4E-like [KO:K03259]
111648156  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
111654800  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111670223  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
111673611  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
111650122  tsc1; hamartin [KO:K07206]
111646396  hamartin-like isoform X1 [KO:K07206]
111666666  tsc2; tuberin isoform X1 [KO:K07207]
111659043  tuberin-like [KO:K07207]
111655861  rheb; GTP-binding protein Rheb [KO:K07208]
111667847  GTP-binding protein Rheb-like [KO:K07208]
111666425  bad; bcl2-associated agonist of cell death [KO:K02158]
111656972  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
111654285  SHC-transforming protein 2-like isoform X1 [KO:K17447]
111664807  shc3; SHC-transforming protein 3 [KO:K17448]
111661140  shc4; SHC-transforming protein 4 [KO:K17449]
111673746  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111653428  sos1; son of sevenless homolog 1 [KO:K03099]
111665903  sos2; son of sevenless homolog 2 [KO:K03099]
111661823  hras; GTPase HRas [KO:K02833]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111647945  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
111664218  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111652614  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111656365  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
111654855  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111669627  ETS domain-containing protein Elk-1-like [KO:K04375]
111663256  suppressor of cytokine signaling 1-like [KO:K04694]
111647510  socs1; suppressor of cytokine signaling 1 [KO:K04694]
111669171  suppressor of cytokine signaling 2-like [KO:K04695]
111657717  socs3; suppressor of cytokine signaling 3 [KO:K04696]
111673508  suppressor of cytokine signaling 3-like [KO:K04696]
111654712  socs4; suppressor of cytokine signaling 4 [KO:K04697]
111661874  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
111671676  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
111655880  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111655298  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
111666355  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
111669531  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
slal00010  Glycolysis / Gluconeogenesis
slal00061  Fatty acid biosynthesis
slal00500  Starch and sucrose metabolism
slal04010  MAPK signaling pathway
slal04070  Phosphatidylinositol signaling system
slal04210  Apoptosis
KO pathway
ko04910   
LinkDB

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