KEGG ORTHOLOGY: K05148

ORTHOLOGY: K05148

Entry

K05148                      KO

Symbol

TNFRSF11B, OPG

Name

tumor necrosis factor receptor superfamily member 11B

Pathway

map04060

Cytokine-cytokine receptor interaction

map04380

Osteoclast differentiation

Disease

H00437

Paget disease of bone

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
Cytokine receptors [BR:ko04050]
Tumor necrosis factor receptors
  TNF receptor superfamily
   K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B

Other DBs

GO:

0005031

Genes

HSA:	4982(TNFRSF11B)

PTR:	464351(TNFRSF11B)

PPS:	100984140(TNFRSF11B)

GGO:	109025349(TNFRSF11B)

PON:	100433420(TNFRSF11B)

PPYG:

129041965(TNFRSF11B)

NLE:	100599407(TNFRSF11B)

HMH:	116813544(TNFRSF11B)

SSYN:

129486744(TNFRSF11B)

MCC:	701850(TNFRSF11B)

MCF:	102118404(TNFRSF11B)

MTHB:

126961557

MNI:	105468534(TNFRSF11B)

CSAB:

103237340(TNFRSF11B)

CATY:

105584542(TNFRSF11B)

PANU:

101002133(TNFRSF11B)

TGE:	112630758(TNFRSF11B)

MLEU:

105534288(TNFRSF11B)

RRO:	104658898(TNFRSF11B)

RBB:	108536211(TNFRSF11B)

TFN:	117079184(TNFRSF11B)

PTEH:

111549925(TNFRSF11B)

CANG:

105511050(TNFRSF11B)

CJC:	100399751(TNFRSF11B)

SBQ:	101052494(TNFRSF11B)

CIMI:

108305919(TNFRSF11B)

ANAN:

105710823(TNFRSF11B)

CSYR:

103275806(TNFRSF11B)

MMUR:

105865335(TNFRSF11B)

LCAT:

123644708(TNFRSF11B)

ERUF:

138381665(TNFRSF11B)

PCOQ:

105812170(TNFRSF11B)

OGA:	100943286(TNFRSF11B)

MMU:	18383(Tnfrsf11b)

MCAL:

110310809(Tnfrsf11b)

MPAH:

110335158(Tnfrsf11b)

RNO:	25341(Tnfrsf11b)

MCOC:

116081769(Tnfrsf11b)

ANU:	117719409(Tnfrsf11b)

ASYL:

127668058(Tnfrsf11b)

MUN:	110564461(Tnfrsf11b)

CGE:	100754507(Tnfrsf11b)

MAUA:

101833931(Tnfrsf11b)

PROB:

127235300(Tnfrsf11b)

PLEU:

114694843(Tnfrsf11b)

PMAV:

102924453(Tnfrsf11b)

MORG:

121461269(Tnfrsf11b)

MFOT:

126503430

AAMP:

119822991(Tnfrsf11b)

CNL:	130888647(Tnfrsf11b)

NGI:	103738137(Tnfrsf11b)

HGL:	101709512(Tnfrsf11b)

CPOC:

100715850(Tnfrsf11b)

CCAN:

109702520(Tnfrsf11b)

DORD:

105997704(Tnfrsf11b)

DSP:	122102353(Tnfrsf11b)

DMER:

138806320(Tnfrsf11b)

PLOP:

125360908(Tnfrsf11b)

NCAR:

124989440

SVUL:

306662327(TNFRSF11B)

MMMA:

107142878(Tnfrsf11b)

ITI:	101971743(Tnfrsf11b)

SCIL:

308633646(TNFRSF11B)

MAVE:

308261865(TNFRSF11B)

OCU:	100348133(TNFRSF11B)

OPI:	101536316(TNFRSF11B)

OCZ:	121155966(TNFRSF11B)

TUP:	102495629(TNFRSF11B)

GVR:	103597104(TNFRSF11B)

CFA:	100855848(TNFRSF11B)

CLUD:

112662449(TNFRSF11B)

VVP:	112915943(TNFRSF11B)

VLG:	121498457(TNFRSF11B)

NPO:	129502354(TNFRSF11B)

AML:	100465761(TNFRSF11B)

UMR:	103661589(TNFRSF11B)

UAH:	113252783(TNFRSF11B)

UAR:	123797758(TNFRSF11B)

ELK:

111146632

LLV:

125099204

MPUF:

101693152(TNFRSF11B)

MNP:	132014253(TNFRSF11B)

MLK:	131826467(TNFRSF11B)

NVS:	122904348(TNFRSF11B)

MMAQ:

308340634(TNFRSF11B)

ORO:	101374351(TNFRSF11B)

EJU:	114199092(TNFRSF11B)

ZCA:	113916742(TNFRSF11B)

MLX:	118015152(TNFRSF11B)

MANO:

123858777(TNFRSF11B)

NSU:	110578861(TNFRSF11B)

LWW:	102732747(TNFRSF11B)

FCA:	101096878(TNFRSF11B)

PYU:	121042896(TNFRSF11B)

PCOO:

112859274(TNFRSF11B)

PBG:	122495750(TNFRSF11B)

PVIV:

125156638(TNFRSF11B)

LRUF:

124507466

LGF:	123585546(TNFRSF11B)

AJU:

106975534

PTG:	102954211(TNFRSF11B)

PPAD:

109273227(TNFRSF11B)

PUC:

125924453

PLEZ:

122210876(TNFRSF11B)

HHV:	120228662(TNFRSF11B)

CCRU:

144243795(TNFRSF11B)

BTA:	523822(TNFRSF11B)

BOM:	102280869(TNFRSF11B)

BIU:	109568703(TNFRSF11B)

BJV:	133260591(TNFRSF11B)

BBUB:

102413271(TNFRSF11B)

BKE:	129626853(TNFRSF11B)

BBIS:

105005434(TNFRSF11B)

CHX:	100860896(TNFRSF11B)

OAS:	100037695(TNFRSF11B)

OCAN:

138446240(TNFRSF11B)

BTAX:

128059488(TNFRSF11B)

CSUM:

138088533(TNFRSF11B)

ODA:	120879011(TNFRSF11B)

CCAD:

122450870(TNFRSF11B)

MREE:

136145162(TNFRSF11B)

OVR:	110134500(TNFRSF11B)

MBEZ:

129559914(TNFRSF11B)

SSC:	100049688(TNFRSF11B)

CFR:	102508939(TNFRSF11B)

CBAI:

105082894(TNFRSF11B)

CDK:	105096145(TNFRSF11B)

VPC:	102526057(TNFRSF11B)

BACU:

103020924(TNFRSF11B)

BMUS:

118883309(TNFRSF11B)

LVE:	103078166(TNFRSF11B)

OOR:	101285576(TNFRSF11B)

LALB:

132508165(TNFRSF11B)

GMF:	115863182(TNFRSF11B)

DDP:	132413230(TNFRSF11B)

SCOO:

307176064(TNFRSF11B)

PCRS:

137209938(TNFRSF11B)

DLE:	111165217(TNFRSF11B)

PCAD:

102987438(TNFRSF11B)

PSIU:

116742644(TNFRSF11B)

PPHC:

136137146(TNFRSF11B)

NASI:

112397203(TNFRSF11B)

HAMP:

307065807(TNFRSF11B)

ECB:	100065885(TNFRSF11B)

EPZ:	103547498(TNFRSF11B)

EAI:	106848049(TNFRSF11B)

MYB:	102246225(TNFRSF11B)

MYD:	102763908(TNFRSF11B)

MMYO:

118670819(TNFRSF11B)

MLF:	102442319(TNFRSF11B)

MDT:	132219584(TNFRSF11B)

MYUM:

138993508(TNFRSF11B)

PKL:	118718231(TNFRSF11B)

EFUS:

103287658(TNFRSF11B)

POTS:

308236722(TNFRSF11B)

MNA:	107533181(TNFRSF11B)

DRO:	112315593(TNFRSF11B)

SHON:

118988622(TNFRSF11B)

AJM:	119051827(TNFRSF11B)

PDIC:

114514631(TNFRSF11B)

PHAS:

123833154(TNFRSF11B)

MMF:	118631473(TNFRSF11B)

PPAM:

129084069(TNFRSF11B)

HAI:	109382519(TNFRSF11B)

RFQ:	117033796(TNFRSF11B)

RHII:

308507029(TNFRSF11B)

PALE:

102882071(TNFRSF11B)

PGIG:

120595471(TNFRSF11B)

PVP:	105292242(TNFRSF11B)

RAY:	107512208(TNFRSF11B)

MJV:	108385695(TNFRSF11B)

TOD:	119238564(TNFRSF11B)

SARA:

101547851(TNFRSF11B)

SFUM:

130020471(TNFRSF11B)

SETR:

126009097(TNFRSF11B)

LAV:	100655062(TNFRSF11B)

TMU:

101356713

ETF:	101659058(TNFRSF11B)

DNM:	101426145(TNFRSF11B)

MDO:	100031818(TNFRSF11B)

GAS:	123231942(TNFRSF11B)

SHR:	100931461(TNFRSF11B)

AFZ:

127544395

PCW:	110200312(TNFRSF11B)

TVP:	118850450(TNFRSF11B)

PBRV:

138156124(TNFRSF11B)

MLAO:

141498334(TNFRSF11B)

OAA:	100086997(TNFRSF11B)

TACU:

119927354(TNFRSF11B)

GGA:	378803(TNFRSF11B)

PCOC:

116227696(TNFRSF11B)

MGP:	100542423(TNFRSF11B)

CJO:	107310514(TNFRSF11B)

TPAI:

128090884(TNFRSF11B)

LMUT:

125691437(TNFRSF11B)

NMEL:

110393894(TNFRSF11B)

APLA:

101791841(TNFRSF11B)

AACU:

137851424(TNFRSF11B)

OJA:	118162545(TNFRSF11B)

BCLA:

308440841(TNFRSF11B)

ACYG:

106038513(TNFRSF11B)

ABRC:

308188718(TNFRSF11B)

CATA:

118252722(TNFRSF11B)

AFUL:

116486632(TNFRSF11B)

TGU:	100225011(TNFRSF11B)

LSR:	110479294(TNFRSF11B)

VMC:	128819426(TNFRSF11B)

VCHA:

128800878(TNFRSF11B)

AIB:	137469549(TNFRSF11B)

SCAN:

103814240(TNFRSF11B)

PMOA:

120505206(TNFRSF11B)

OTC:	121337421(TNFRSF11B)

PRUF:

121355426(TNFRSF11B)

ATRC:

139587402(TNFRSF11B)

MATE:

118684201(TNFRSF11B)

MAEN:

136555428(TNFRSF11B)

GFR:	102044228(TNFRSF11B)

FAB:	101815972(TNFRSF11B)

OMA:	130249049(TNFRSF11B)

PHI:	102099429(TNFRSF11B)

PMAJ:

107200868(TNFRSF11B)

CCAE:

111925071(TNFRSF11B)

CCW:	104692674(TNFRSF11B)

CBRC:

103623521(TNFRSF11B)

ACOE:

138105418(TNFRSF11B)

ETL:	114057990(TNFRSF11B)

ZAB:	102067348(TNFRSF11B)

ZLE:	135444631(TNFRSF11B)

ACHL:

103810149(TNFRSF11B)

SVG:	106849481(TNFRSF11B)

MMEA:

130574563(TNFRSF11B)

HRT:	120763186(TNFRSF11B)

SATI:

136371233(TNFRSF11B)

CFAI:

136285597(TNFRSF11B)

CCIC:

134050512(TNFRSF11B)

NNT:	104402764(TNFRSF11B)

SHAB:

115616388(TNFRSF11B)

POCC:

134167932(TNFRSF11B)

FPG:	101917354(TNFRSF11B)

FCH:	102054375(TNFRSF11B)

FRS:	119145463(TNFRSF11B)

CCRI:

104156348(TNFRSF11B)

ACUN:

113477076(TNFRSF11B)

ANOC:

141957293(TNFRSF11B)

SURA:

141951121(TNFRSF11B)

TALA:

104357857(TNFRSF11B)

ACHC:

115340437(TNFRSF11B)

HALD:

104312097(TNFRSF11B)

HLE:	104837691(TNFRSF11B)

AGEN:

126049042

HHAR:

128142034(TNFRSF11B)

BBUT:

142029266(TNFRSF11B)

GCL:

127013220

CSTI:

104558791(TNFRSF11B)

LDI:	104347153(TNFRSF11B)

MNB:	103782247(TNFRSF11B)

DPUB:

104297236(TNFRSF11B)

PPUS:

135181209(TNFRSF11B)

IIN:	128970186(TNFRSF11B)

AVIT:

104281025(TNFRSF11B)

BRHI:

104498532(TNFRSF11B)

EGZ:	104123710(TNFRSF11B)

NNI:	104018001(TNFRSF11B)

PCRI:

104025230(TNFRSF11B)

PCAO:

104053602(TNFRSF11B)

PARX:

142053672(TNFRSF11B)

PADL:

103914945(TNFRSF11B)

AFOR:

103897224(TNFRSF11B)

FGA:	104077711(TNFRSF11B)

CBOR:

142079819(TNFRSF11B)

GSTE:

104255541(TNFRSF11B)

CBOY:

140647414(TNFRSF11B)

MAME:

142406366(TNFRSF11B)

CLV:	102086049(TNFRSF11B)

CNIC:

135985412(TNFRSF11B)

NMAY:

308038197(TNFRSF11B)

MUI:	104539084(TNFRSF11B)

PGUU:

104462075(TNFRSF11B)

PLET:

104619537(TNFRSF11B)

EHS:	104512975(TNFRSF11B)

CMAC:

104477750(TNFRSF11B)

CUCA:

104066188(TNFRSF11B)

PCUR:

138719354(TNFRSF11B)

TEO:	104382466(TNFRSF11B)

BREG:

104632376(TNFRSF11B)

GAME:

129203563(TNFRSF11B)

OHA:	104332474 104332483

ACAR:

104528390(TNFRSF11B)

CEUR:

306717243(TNFRSF11B)

CPEA:

104386716(TNFRSF11B)

CVF:	104282861(TNFRSF11B)

RTD:	128906168(TNFRSF11B)

CRID:

134512218(TNFRSF11B)

LMIC:

141739778(TNFRSF11B)

NARQ:

141463227(TNFRSF11B)

AAM:	106496306(TNFRSF11B)

AROW:

112960957(TNFRSF11B)

NPD:	112948506(TNFRSF11B)

TGT:	104578312(TNFRSF11B)

DNE:	112989189(TNFRSF11B)

SCAM:

104149347(TNFRSF11B)

ASN:	102368531(TNFRSF11B)

AMJ:	102565506(TNFRSF11B)

CPOO:

109321496(TNFRSF11B)

GGN:	109305154(TNFRSF11B)

PSS:	102443687(TNFRSF11B)

CIZ:	142008452(TNFRSF11B)

CMY:	102939155(TNFRSF11B)

CCAY:

125632787(TNFRSF11B)

LKP:	140906405(TNFRSF11B)

NDS:	141982140(TNFRSF11B)

DCC:	119851185(TNFRSF11B)

CPIC:

101953352(TNFRSF11B)

TST:	117873769(TNFRSF11B)

CABI:

116822982(TNFRSF11B)

MRV:	120396496(TNFRSF11B)

EMQ:	137141334(TNFRSF11B)

ACS:	100565448(tnfrsf11b)

ASAO:

132775073(TNFRSF11B)

PVT:	110091297(TNFRSF11B)

SUND:

121927754(TNFRSF11B)

PBI:	103049556(TNFRSF11B)

PMUR:

107288745(TNFRSF11B)

CTIG:

120317963(TNFRSF11B) 120319516

TSR:	106542347(TNFRSF11B)

PGUT:

117668448(TNFRSF11B)

PCAE:

139314470(TNFRSF11B)

APRI:

131196110(TNFRSF11B)

PTEX:

113438274(TNFRSF11B)

NSS:	113427103(TNFRSF11B)

VKO:	123019344(TNFRSF11B)

PMUA:

114600294(TNFRSF11B)

PRAF:

128417123(TNFRSF11B)

ZVI:	118090515(TNFRSF11B)

HCG:	128322032(TNFRSF11B)

GJA:	107116114(TNFRSF11B)

STOW:

125439497(TNFRSF11B)

EMC:	129333585(TNFRSF11B)

XLA:	108719391(tnfrsf11b.L) 444716(tnfrsf11b.S)

XTR:	100494982(tnfrsf11b)

NPR:	108784507(TNFRSF11B)

RTEM:

120941484(TNFRSF11B)

ACAT:

141145459(TNFRSF11B)

PADS:

140330536(TNFRSF11B)

BBUF:

121001292(TNFRSF11B)

BGAR:

122938574(TNFRSF11B)

DTC:	141101271(TNFRSF11B)

PWL:	138282776(TNFRSF11B)

MUO:	115479997(TNFRSF11B)

GSH:	117353498(TNFRSF11B)

SRX:	107708300 107714778

SGH:

107572587

CCAR:

109094467 109101228 109111506

CAUA:

CGIB:

PTET:

LROH:

GRF:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

PDAB:

IPU:	108272316 108274553

IFU:	128618385 128619668

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00018286G001

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

SVIT:

ECRA:

ESP:

PFLV:

114557748(tnfrsf11b)

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

TBU:	306744968(LOC306744968)

CVE:

AMIR:

MSAM:

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

LCO:	104920198(tnfrsf11b)

AMMM:

307259468(LOC307259468)

MZE:

101479942

ONL:

102081429

OAU:

116329427

OLA:	101156914(tnfrsf11b)

OML:

112143608

CSAI:

133440940

XMA:	102228653(tnfrsf11b)

XCO:	114142311(tnfrsf11b)

XHE:	116717801(tnfrsf11b)

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:	107378726(tnfrsf11b)

KMR:

ALIM:

NWH:

LTU:

MCEP:

AOCE:

EJA:

BFRE:

LCF:

CSEM:

103388323(tnfrsf11b)

POV:	109632109(tnfrsf11b)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:	111227781(tnfrsf11b)

SLAL:

111657192(tnfrsf11b)

XGL:

120784690

HCQ:	109517660(tnfrsf11b)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110171764(tnfrsf11b)

ENY:

140374297

MALB:

109964871(tnfrsf11b) 109973203

BSPL:

SJO:

SSCO:

TTY:

GMH:

SASA:

106574239 106574253 106596966 106598140 106598178 106598220 106598387

STRU:

115182473 115190909

OTW:	112241752 112253221

OMY:

110520706

OGO:

124020839

OKI:	109885033 109885034

OKE:

127928768

OMM:	135521023 135534832 135535153

OCLA:

139378690 139405629 139418930

SALP:

112074826

SFON:

129856851

CCLU:

121542363 121585473

ELS:	105009165 105016522(tnfrsf11b)

OEP:

134022976

SFM:	108919220 108940494

PKI:	111845180 111852153

AANG:

118234440 118235692

AROT:

135256575 135261496

CCOG:

133107801 133137569

LOC:	102687172(tnfrsf11b)

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

HOC:

LERI:

HAKA:

LRJ:

BFO:	118429409 118430669 118430970 118431083 118431084

BBEL:

109461640 109479650 109479773 109479778 109479798 109480133 109480136

SKO:

GAE:

HRF:

HASI:

CRG:

MYI:

YBA:

LAK:

Reference

PMID:20163972

Authors

Perez-Sayans M, Somoza-Martin JM, Barros-Angueira F, Rey JM, Garcia-Garcia A

Title

RANK/RANKL/OPG role in distraction osteogenesis.

Journal

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:679-86 (2010)
DOI:10.1016/j.tripleo.2009.10.042

Reference

PMID:9168977

Authors

Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K

Title

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

Journal

Biochem Biophys Res Commun 234:137-42 (1997)
DOI:10.1006/bbrc.1997.6603

Sequence

[hsa:4982]

LinkDB

DBGET integrated database retrieval system