KEGG   PATHWAY: apla04150
Entry
apla04150                   Pathway                                
Name
mTOR signaling pathway - Anas platyrhynchos (mallard)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
apla04150  mTOR signaling pathway
apla04150

Organism
Anas platyrhynchos (mallard) [GN:apla]
Gene
101798857  SLC7A5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
101799744  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
101794496  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101805143  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
119715003  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101790910  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
101799536  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
101792552  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101793897  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101792649  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101799077  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101789737  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
119716804  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
101804745  ragulator complex protein LAMTOR2 [KO:K20398]
101800055  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
101789870  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
119713977  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
101793020  FLCN; folliculin [KO:K09594]
101805308  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
101801907  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
101792295  ras-related GTP-binding protein A [KO:K16185]
119717908  LOW QUALITY PROTEIN: ras-related GTP-binding protein A-like [KO:K16185]
101790925  RRAGC; ras-related GTP-binding protein C [KO:K16186]
101800218  RRAGD; ras-related GTP-binding protein D [KO:K16186]
101802403  SESN2; sestrin-2 isoform X1 [KO:K20394]
101796563  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
101803229  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
101797819  MIOS; GATOR complex protein MIOS [KO:K20407]
101796905  SEH1L; LOW QUALITY PROTEIN: nucleoporin SEH1 [KO:K14299]
101798780  WDR24; GATOR complex protein WDR24 [KO:K20408]
101790385  WDR59; GATOR complex protein WDR59 isoform X2 [KO:K20409]
113841666  SEC13; protein SEC13 homolog [KO:K14004]
101797131  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
110353781  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
101798704  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
101802477  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
106019397  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
119713155  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
101802486  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101802012  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
101800454  DEPTOR; LOW QUALITY PROTEIN: DEP domain-containing mTOR-interacting protein [KO:K20402]
101797928  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
101802123  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
101800958  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
101804773  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
101796819  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
101795883  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
101798519  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101795185  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
119713359  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
101797231  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101793905  ULK2; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
101798286  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101797178  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
101789545  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119718363  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101792883  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119717128  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101801250  RPS6; 40S ribosomal protein S6 [KO:K02991]
101800792  STRADA; STE20-related kinase adapter protein alpha isoform X4 [KO:K08271]
101798553  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
101795686  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101802136  CAB39; calcium-binding protein 39 [KO:K08272]
101804370  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
101801595  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101799561  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101798545  TSC1; hamartin isoform X1 [KO:K07206]
101804966  TSC2; tuberin isoform X5 [KO:K07207]
101801159  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
101803921  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
101790553  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
119715309  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101800865  WNT2B; protein Wnt-2b [KO:K00182]
101799824  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
101803262  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101800064  WNT3A; LOW QUALITY PROTEIN: protein Wnt-3a [KO:K00312]
101791711  WNT4; protein Wnt-4 [KO:K00408]
101793827  protein Wnt-4-like [KO:K00408]
101802371  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101792356  WNT5B; protein Wnt-5b [KO:K00444]
101803438  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
101792761  WNT7A; protein Wnt-7a [KO:K00572]
101805245  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
101796899  WNT8B; protein Wnt-8b [KO:K00714]
101797449  WNT8A; protein Wnt-8a [KO:K00714]
101803319  WNT9A; protein Wnt-9a [KO:K01064]
101804224  WNT9B; protein Wnt-9b [KO:K01064]
101803237  WNT10A; protein Wnt-10a [KO:K01357]
101798327  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
119717894  LOW QUALITY PROTEIN: protein Wnt-11b-like [KO:K01384]
101795639  WNT16; protein Wnt-16 [KO:K01558]
101800813  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
101797835  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
101792127  FZD2; frizzled-2 [KO:K02235]
101804946  FZD3; frizzled-3 [KO:K02329]
101804770  FZD4; frizzled-4 [KO:K02354]
101800624  FZD5; frizzled-5 [KO:K02375]
101792494  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
101799157  FZD6; LOW QUALITY PROTEIN: frizzled-6 [KO:K02376]
101793766  FZD10; frizzled-10 [KO:K02842]
101799597  FZD9; frizzled-9 [KO:K02842]
101790390  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
101790650  LRP5; low-density lipoprotein receptor-related protein 5 isoform X2 [KO:K03068]
101795365  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101803917  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101802112  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101801004  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101790255  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101794427  INS; insulin [KO:K04526]
101793597  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101795803  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
101802018  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
101797458  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101802245  SOS1; son of sevenless homolog 1 [KO:K03099]
101804628  SOS2; son of sevenless homolog 2 [KO:K03099]
101793649  HRAS; GTPase HRas [KO:K02833]
101793538  KRAS; GTPase KRas isoform X1 [KO:K07827]
101804733  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
101794380  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101795633  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101791037  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119714201  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101800319  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101792994  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
101798660  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
101797651  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
101800942  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101796950  IRS1; LOW QUALITY PROTEIN: insulin receptor substrate 1 [KO:K16172]
101803461  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101799717  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101795759  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101796183  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101800900  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101802796  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101798136  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101798010  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101804556  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101800458  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119717337  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101799502  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
101803158  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
101802777  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
101800276  PRR5; proline-rich protein 5 isoform X4 [KO:K20411]
101802083  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
101797910  RHOA; transforming protein RhoA [KO:K04513]
101802546  PRKCA; protein kinase C alpha type isoform X3 [KO:K02677] [EC:2.7.11.13]
101799551  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101801765  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
apla00561  Glycerolipid metabolism
apla04010  MAPK signaling pathway
apla04140  Autophagy - animal
apla04810  Regulation of actin cytoskeleton
apla04910  Insulin signaling pathway
KO pathway
ko04150   
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