KEGG   PATHWAY: bbub04142
Entry
bbub04142                   Pathway                                
Name
Lysosome - Bubalus bubalis (water buffalo)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bbub04142  Lysosome
bbub04142

Other DBs
GO: 0005764
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102389631  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
102389849  HYAL1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
102389899  ACP2; lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
102390263  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
102390456  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
102390497  [KO:K01197] [EC:3.2.1.35]
102390506  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
102390683  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
102390833  [KO:K01197] [EC:3.2.1.35]
102391115  ABCA2; ATP-binding cassette sub-family A member 2 isoform X2 [KO:K05642]
102391560  ARSG; arylsulfatase G isoform X2 [KO:K12381] [EC:3.1.6.-]
102391704  AP1S1; AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
102392055  GGA1; ADP-ribosylation factor-binding protein GGA1 isoform X3 [KO:K12404]
102392857  NPC1; NPC intracellular cholesterol transporter 1 isoform X1 [KO:K12385]
102393053  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
102393587  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
102393991  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
102394026  WDR7; WD repeat-containing protein 7 isoform X4 [KO:K24738]
102394284  [KO:K01365] [EC:3.4.22.15]
102394655  CD164; sialomucin core protein 24 isoform X2 [KO:K06546]
102394665  AP1S2; AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
102395187  CTSW; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
102395624  CLN5; ceroid-lipofuscinosis neuronal protein 5 isoform X3 [KO:K12390]
102395799  AP1S3; AP-1 complex subunit sigma-3 isoform X2 [KO:K12395]
102395861  GBA; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
102395954  AP4E1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
102396136  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
102396288  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X1 [KO:K02154]
102397437  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
102397627  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
102397725  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
102397903  [KO:K01319] [EC:3.4.21.20]
102398136  CLTB; clathrin light chain B isoform X1 [KO:K04645]
102398185  CD68; macrosialin [KO:K06501]
102398241  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
102398425  [KO:K01319] [EC:3.4.21.20]
102398714  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
102398732  [KO:K12373] [EC:3.2.1.52]
102398753  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
102398755  [KO:K01195] [EC:3.2.1.31]
102398828  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
102398941  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102399018  [KO:K12394]
102399616  CTSC; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
102399721  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
102399812  CLTC; clathrin heavy chain 1 isoform X4 [KO:K04646]
102399834  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
102401295  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
102401359  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
102401475  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
102401891  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
102401923  LAMP3; lysosome-associated membrane glycoprotein 3 isoform X2 [KO:K06562]
102401940  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
102402267  CTNS; cystinosin [KO:K12386]
102402763  GNS; N-acetylglucosamine-6-sulfatase isoform X2 [KO:K01137] [EC:3.1.6.14]
102403479  TCIRG1; V-type proton ATPase 116 kDa subunit a3 isoform X1 [KO:K02154]
102403622  AP3D1; AP-3 complex subunit delta-1 isoform X2 [KO:K12396]
102403898  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
102403952  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
102404247  [KO:K06497]
102404392  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102404481  MANBA; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
102404540  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
102404562  AP3S1; AP-3 complex subunit sigma-1 isoform X3 [KO:K12399]
102404676  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
102404704  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
102404738  CD63; CD63 antigen [KO:K06497]
102405015  SLC11A1; natural resistance-associated macrophage protein 1 isoform X3 [KO:K12347]
102405239  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
102405713  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
102405734  SLC11A2; natural resistance-associated macrophage protein 2 isoform X3 [KO:K21398]
102405950  [KO:K12387]
102406200  MFSD8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
102406309  MEAK7; MTOR-associated protein MEAK7 isoform X3 [KO:K27947]
102406577  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
102407044  GM2A; ganglioside GM2 activator [KO:K12383]
102407192  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
102407231  [KO:K21398]
102407535  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
102407636  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
102407679  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
102407700  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
102407712  CLN3; battenin isoform X2 [KO:K12389]
102407744  [KO:K12373] [EC:3.2.1.52]
102407761  [KO:K12399]
102407783  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
102408133  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
102408292  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform X2 [KO:K02154]
102408311  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
102408343  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
102408571  SGSH; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
102408891  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
102408971  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102408973  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
102409621  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
102409788  DNASE2B; deoxyribonuclease-2-beta isoform X2 [KO:K01158] [EC:3.1.22.1]
102410391  DMXL1; dmX-like protein 1 isoform X1 [KO:K24155]
102410466  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
102410676  [KO:K01195] [EC:3.2.1.31]
102410738  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
102410901  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
102410975  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
102411474  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
102411477  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
102411640  CTSF; cathepsin F isoform X2 [KO:K01373] [EC:3.4.22.41]
102411702  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
102411837  [KO:K21398]
102411950  SPAM1; hyaluronidase PH-20 [KO:K01197] [EC:3.2.1.35]
102412202  IDUA; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
102412255  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
102412309  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
102412544  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
102412553  DMXL2; dmX-like protein 2 isoform X3 [KO:K24155]
102412556  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
102412607  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
102412612  GALC; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
102412668  SORT1; sortilin isoform X1 [KO:K12388]
102413028  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
102413123  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
102413133  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102413180  CTSH; pro-cathepsin H isoform X2 [KO:K01366] [EC:3.4.22.16]
102413231  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
102413248  SCARB2; lysosome membrane protein 2 isoform X2 [KO:K12384]
102413291  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
102413360  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X7 [KO:K02154]
102413690  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1 [KO:K19363]
102413741  SLC17A5; sialin isoform X3 [KO:K12301]
102413845  MCOLN1; mucolipin-1 [KO:K04992]
102414452  NAPSA; napsin-A [KO:K08565] [EC:3.4.23.-]
102414818  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
102414906  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
102415424  CLTA; clathrin light chain A isoform X1 [KO:K04644]
102415724  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
102415765  HYAL3; hyaluronidase-3 isoform X2 [KO:K01197] [EC:3.2.1.35]
102415936  AP1G2; AP-1 complex subunit gamma-like 2 isoform X2 [KO:K12391]
102415995  GLB1; beta-galactosidase isoform X3 [KO:K12309] [EC:3.2.1.23]
102416033  [KO:K12382]
102416469  NCOA7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
102416653  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528]
112581844  LITAFD; lITAF domain-containing protein [KO:K19363]
123333647  [KO:K06546]
123465395  [KO:K12393]
123465573  [KO:K12387]
123465682  [KO:K12399]
123466185  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bbub00511  Other glycan degradation
bbub00531  Glycosaminoglycan degradation
bbub04130  SNARE interactions in vesicular transport
bbub04140  Autophagy - animal
bbub04144  Endocytosis
KO pathway
ko04142   

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