KEGG   PATHWAY: bpy00260
Entry
bpy00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Paraburkholderia phytofirmans PsJN
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bpy00260  Glycine, serine and threonine metabolism
bpy00260

Module
bpy_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bpy00260]
bpy_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bpy00260]
bpy_M00555  Betaine biosynthesis, choline => betaine [PATH:bpy00260]
bpy_M00621  Glycine cleavage system [PATH:bpy00260]
bpy_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bpy00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paraburkholderia phytofirmans PsJN [GN:bpy]
Gene
Bphyt_2506  aspartate kinase [KO:K00928] [EC:2.7.2.4]
Bphyt_6846  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
Bphyt_1806  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
Bphyt_6795  homoserine kinase [KO:K02204] [EC:2.7.1.39]
Bphyt_1807  threonine synthase [KO:K01733] [EC:4.2.3.1]
Bphyt_2821  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Bphyt_5968  Threonine aldolase [KO:K01620] [EC:4.1.2.48]
Bphyt_0765  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bphyt_5063  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bphyt_0271  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Bphyt_6959  Serine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Bphyt_0791  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Bphyt_6144  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00018] [EC:1.1.1.29]
Bphyt_6350  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00018] [EC:1.1.1.29]
Bphyt_6094  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bphyt_0441  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K12972] [EC:1.1.1.79 1.1.1.81]
Bphyt_2276  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bphyt_2929  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
Bphyt_1904  Glycerate kinase [KO:K00865] [EC:2.7.1.165]
Bphyt_0534  phosphoglycerate mutase 1 family [KO:K01834] [EC:5.4.2.11]
Bphyt_3348  Phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
Bphyt_0303  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bphyt_6458  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00058] [EC:1.1.1.95 1.1.1.399]
Bphyt_3007  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
Bphyt_1855  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
Bphyt_0764  short-chain dehydrogenase/reductase SDR [KO:K16066] [EC:1.1.1.381 1.1.1.-]
Bphyt_7004  2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
Bphyt_7003  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
Bphyt_1997  Amine oxidase (copper-containing) [KO:K00276] [EC:1.4.3.21]
Bphyt_3882  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Bphyt_3880  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Bphyt_2589  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bphyt_1642  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Bphyt_3881  glycine cleavage system H protein [KO:K02437]
Bphyt_1332  CDP-diacylglycerol/serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
Bphyt_5058  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
Bphyt_5059  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
Bphyt_5070  Rieske (2Fe-2S) domain protein [KO:K00479] [EC:1.14.13.251]
Bphyt_5071  Oxidoreductase FAD-binding domain protein [KO:K21832] [EC:1.14.13.251]
Bphyt_5066  NADH:flavin oxidoreductase/NADH oxidase [KO:K21833] [EC:1.5.7.3]
Bphyt_5067  protein of unknown function DUF224 cysteine-rich region domain protein [KO:K21834]
Bphyt_5068  Electron transfer flavoprotein alpha subunit [KO:K25960]
Bphyt_5069  putative electron transfer flavoprotein beta-subunit [KO:K25961]
Bphyt_5050  sarcosine oxidase, alpha subunit family [KO:K00302] [EC:1.5.3.24 1.5.3.1]
Bphyt_5048  sarcosine oxidase, beta subunit family [KO:K00303] [EC:1.5.3.24 1.5.3.1]
Bphyt_5051  Sarcosine oxidase gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
Bphyt_5049  Sarcosine oxidase delta subunit heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
Bphyt_3884  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Bphyt_5047  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
Bphyt_2231  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Bphyt_1872  Pyridoxal-5'-phosphate-dependent protein beta subunit [KO:K01754] [EC:4.3.1.19]
Bphyt_0645  threonine dehydratase, biosynthetic [KO:K01754] [EC:4.3.1.19]
Bphyt_0639  putative D-serine deaminase (d-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
Bphyt_2599  aspartate racemase [KO:K25316] [EC:5.1.1.10]
Bphyt_6840  tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
Bphyt_6842  tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
Bphyt_1110  Ectoine synthase [KO:K06720] [EC:4.2.1.108]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bpy00010  Glycolysis / Gluconeogenesis
bpy00020  Citrate cycle (TCA cycle)
bpy00230  Purine metabolism
bpy00250  Alanine, aspartate and glutamate metabolism
bpy00270  Cysteine and methionine metabolism
bpy00290  Valine, leucine and isoleucine biosynthesis
bpy00300  Lysine biosynthesis
bpy00330  Arginine and proline metabolism
bpy00460  Cyanoamino acid metabolism
bpy00470  D-Amino acid metabolism
bpy00564  Glycerophospholipid metabolism
bpy00620  Pyruvate metabolism
bpy00630  Glyoxylate and dicarboxylate metabolism
bpy00640  Propanoate metabolism
bpy00680  Methane metabolism
bpy00860  Porphyrin metabolism
bpy00920  Sulfur metabolism
KO pathway
ko00260   
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