KEGG   PATHWAY: btax04142
Entry
btax04142                   Pathway                                
Name
Lysosome - Budorcas taxicolor (takin)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
btax04142  Lysosome
btax04142

Other DBs
GO: 0005764
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128043295  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
128043430  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
128043446  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
128043492  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
128043766  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
128043814  [KO:K01195] [EC:3.2.1.31]
128044402  GBA1; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
128044419  AP4B1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
128044625  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
128044897  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
128044918  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
128045111  DNASE2B; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
128045201  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
128045316  SORT1; sortilin isoform X1 [KO:K12388]
128046304  [KO:K01197] [EC:3.2.1.35]
128046809  SUMF1; formylglycine-generating enzyme isoform X1 [KO:K13444] [EC:1.8.3.7]
128046946  [KO:K01197] [EC:3.2.1.35]
128046951  [KO:K01197] [EC:3.2.1.35]
128047038  HYAL4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
128047063  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
128047474  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
128047475  [KO:K21398]
128047476  [KO:K21398]
128047513  GNS; N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
128047550  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
128047598  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
128047638  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
128047713  CD63; CD63 antigen [KO:K06497]
128047735  PSAP; prosaposin [KO:K12382]
128047737  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
128047977  ARSA; arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
128048353  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
128048798  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
128048805  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
128048834  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
128049415  SCARB2; lysosome membrane protein 2 [KO:K12384]
128049431  PSAPL1; proactivator polypeptide-like 1 [KO:K12382]
128049607  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
128049860  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
128050317  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
128050608  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
128050610  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
128050668  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
128051210  CLTB; clathrin light chain B isoform X1 [KO:K04645]
128051357  GM2A; ganglioside GM2 activator [KO:K12383]
128051364  AP1M2; AP-1 complex subunit mu-2 [KO:K12393]
128051394  DNASE2; deoxyribonuclease-2-alpha isoform X1 [KO:K01158] [EC:3.1.22.1]
128051403  DMXL1; dmX-like protein 1 [KO:K24155]
128051448  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
128052033  CLTA; clathrin light chain A isoform X1 [KO:K04644]
128052151  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
128052199  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
128052286  [KO:K01365] [EC:3.4.22.15]
128052428  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
128053042  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
128053062  CD164; sialomucin core protein 24 isoform X1 [KO:K06546]
128053201  NCOA7; nuclear receptor coactivator 7 [KO:K25442]
128053258  SLC17A5; sialin isoform X1 [KO:K12301]
128053428  FUCA2; plasma alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
128053572  [KO:K12387]
128053872  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
128053946  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
128053989  ARSB; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
128054092  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
128054173  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
128054205  AP3S1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
128054215  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
128054359  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
128054859  DMXL2; dmX-like protein 2 [KO:K24155]
128055819  PPT2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
128055980  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
128056405  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
128056587  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
128056999  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
128057468  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
128057643  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
128058117  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
128058268  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
128059159  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
128059555  LAPTM4B; lysosomal-associated transmembrane protein 4B isoform X1 [KO:K12387]
128059594  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
128059804  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
128060235  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
128060387  TPP1; tripeptidyl-peptidase 1 isoform X1 [KO:K01279] [EC:3.4.14.9]
128062062  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
128062278  ABCB9; ABC-type oligopeptide transporter ABCB9 [KO:K05656]
128062447  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
128062564  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
128062600  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
128062961  AP1G1; AP-1 complex subunit gamma-1 [KO:K12391]
128063020  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
128063200  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
128063323  GALNS; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
128063364  NAPSA; LOW QUALITY PROTEIN: napsin-A [KO:K08565] [EC:3.4.23.-]
128063654  MEAK7; MTOR-associated protein MEAK7 [KO:K27947]
128064204  GGA2; ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
128064417  ARSG; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
128064515  GAA; lysosomal alpha-glucosidase isoform X1 [KO:K12316] [EC:3.2.1.20]
128064552  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
128064679  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
128064693  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
128064891  CTNS; cystinosin [KO:K12386]
128064910  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
128065225  CD68; macrosialin [KO:K06501]
128065406  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
128066152  [KO:K12373] [EC:3.2.1.52]
128066245  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
128066434  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
128066616  AP3B2; AP-3 complex subunit beta-2 [KO:K12397]
128066617  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
128066659  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
128066749  [KO:K01319] [EC:3.4.21.20]
128067038  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
128067249  [KO:K01195] [EC:3.2.1.31]
128067315  WDR7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
128067367  [KO:K12385]
128067388  [KO:K12385]
128067788  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
128068212  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
128068242  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
128068293  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
128068307  ASAH1; acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
128068501  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
128068646  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
128068661  CTSF; cathepsin F isoform X1 [KO:K01373] [EC:3.4.22.41]
128068741  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
128068966  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
128069449  CLN3; battenin isoform X1 [KO:K12389]
128069659  [KO:K06497]
128069673  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
128069764  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
128069894  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
128069986  AP1S2; AP-1 complex subunit sigma-2 [KO:K12394]
128069988  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
128070213  IDS; iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
128070420  LAPTM5; lysosomal-associated transmembrane protein 5 [KO:K12387]
128070571  SLC11A1; natural resistance-associated macrophage protein 1 [KO:K12347]
128071021  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
128071295  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
btax00511  Other glycan degradation
btax00531  Glycosaminoglycan degradation
btax04130  SNARE interactions in vesicular transport
btax04140  Autophagy - animal
btax04144  Endocytosis
KO pathway
ko04142   

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