KEGG PATHWAY: cabi04672

KEGG

PATHWAY: cabi04672

Entry

cabi04672                   Pathway

Name

Intestinal immune network for IgA production - Chelonoidis abingdonii (Abingdon island giant tortoise)

Description

The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.

Class

Organismal Systems; Immune system

Pathway map

Intestinal immune network for IgA production

Other DBs

GO:

Organism

Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]

Gene

TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]

CXCL12; stromal cell-derived factor 1 [KO:K10031]

CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]

IL15; interleukin-15 isoform X1 [KO:K05433]

CCR10; LOW QUALITY PROTEIN: C-C chemokine receptor type 10 [KO:K04185]

CD40LG; CD40 ligand [KO:K03161]

TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]

AICDA; single-stranded DNA cytosine deaminase isoform X1 [KO:K10989] [EC:3.5.4.38]

CCL28; LOW QUALITY PROTEIN: C-C motif chemokine 28 [KO:K05513]

MADCAM1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]

CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]

ITGA4; integrin alpha-4 [KO:K06483]

ITGB7; integrin beta-7 [KO:K06590]

TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]

IL6; interleukin-6 [KO:K05405]

PIGR; polymeric immunoglobulin receptor isoform X1 [KO:K13073]

IL10; interleukin-10 [KO:K05443]

TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]

CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]

TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]

MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]

IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]

ICOSLG; ICOS ligand [KO:K06710]

CD80; T-lymphocyte activation antigen CD80 [KO:K05412]

TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]

Compound

Retinoate

9-cis-Retinoic acid

Reference

Authors

Fagarasan S, Honjo T

Title

Intestinal IgA synthesis: regulation of front-line body defences.

Journal

Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982

Reference

Authors

Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P

Title

The immune geography of IgA induction and function.

Journal

Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6

Reference

Authors

Kunisawa J, Kiyono H

Title

A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.

Journal

Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1

Reference

Authors

Cerutti A, Rescigno M

Title

The biology of intestinal immunoglobulin A responses.

Journal

Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001

Reference

Authors

Tsuji M, Suzuki K, Kinoshita K, Fagarasan S

Title

Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.

Journal

Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003

Reference

Authors

Corthesy B

Title

Roundtrip ticket for secretory IgA: role in mucosal homeostasis?

Journal

J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27

Reference

Authors

Suzuki K, Fagarasan S

Title

How host-bacterial interactions lead to IgA synthesis in the gut.

Journal

Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001

Reference

Authors

Mora JR, von Andrian UH

Title

Differentiation and homing of IgA-secreting cells.

Journal

Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14

Reference

Authors

Suzuki K, Ha SA, Tsuji M, Fagarasan S

Title

Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.

Journal

Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001

Reference

Authors

Cerutti A

Title

The regulation of IgA class switching.

Journal

Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322

KO pathway

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