KEGG   PATHWAY: ccan04514
Entry
ccan04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Castor canadensis (American beaver)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ccan04514  Cell adhesion molecule (CAM) interaction
ccan04514

Other DBs
GO: 0050839
Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109674022  Cxadr; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
109674137  Nlgn2; neuroligin-2 [KO:K07378]
109674284  Cldn34; claudin-34 [KO:K06087]
109674385  Nlgn3; neuroligin-3 isoform X1 [KO:K07378]
109674452  Ctla4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
109674577  Cldn7; claudin-7 [KO:K06087]
109674664  [KO:K06752]
109674665  [KO:K06752]
109674702  [KO:K06752]
109674703  [KO:K06752]
109675125  Cd226; CD226 antigen [KO:K06567]
109675252  Igsf11; immunoglobulin superfamily member 11 [KO:K06791]
109675586  Slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
109675689  Slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
109676269  Cldn8; claudin-8 [KO:K06087]
109676272  Cldn17; claudin-17 [KO:K06087]
109676541  Cldn23; claudin-23 [KO:K06087]
109676722  [KO:K06081]
109676730  Ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
109676902  Nlgn1; neuroligin-1 isoform X1 [KO:K07378]
109678483  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
109678642  [KO:K06815]
109679450  Vcam1; vascular cell adhesion protein 1 [KO:K06527]
109679493  Slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]
109679566  [KO:K06775]
109679781  Slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
109679926  [KO:K07378]
109681519  Cd40lg; CD40 ligand [KO:K03161]
109681560  Ptprf; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
109681570  [KO:K06585]
109681628  [KO:K06523]
109681738  Sdc1; LOW QUALITY PROTEIN: syndecan-1 [KO:K06257]
109681742  Sdc3; syndecan-3 isoform X1 [KO:K16337]
109682249  Cd86; T-lymphocyte activation antigen CD86 [KO:K05413]
109682463  Pdcd1; programmed cell death protein 1 [KO:K06744]
109682539  Esam; endothelial cell-selective adhesion molecule [KO:K06787]
109682543  Spn; leukosialin [KO:K06477]
109682769  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
109682962  Icos; inducible T-cell costimulator [KO:K06713]
109683028  Itgal; integrin alpha-L isoform X1 [KO:K05718]
109683628  Pdcd1lg2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
109683630  Cd274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
109683829  Cldn1; claudin-1 [KO:K06087]
109683834  Cldn16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
109683861  Lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]
109684070  Itgb7; integrin beta-7 [KO:K06590]
109684315  Cldn5; claudin-5 [KO:K06087]
109684411  Jaml; junctional adhesion molecule-like isoform X1 [KO:K28137]
109684954  Ncam1; neural cell adhesion molecule 1 [KO:K06491]
109684956  Ntng2; netrin-G2 isoform X1 [KO:K16359]
109684977  Glg1; Golgi apparatus protein 1 [KO:K06816]
109685403  Vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
109685448  Cd34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
109685696  Ocln; LOW QUALITY PROTEIN: occludin [KO:K06088]
109685982  [KO:K06752]
109686100  Madcam1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
109686646  Itgav; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
109686673  [KO:K06752]
109686675  [KO:K06752]
109686676  [KO:K06752]
109686704  [KO:K06752]
109686705  [KO:K06752]
109686915  [KO:K06087]
109686941  [KO:K06087]
109686949  [KO:K06087]
109687104  Nrxn2; neurexin-2-beta isoform X1 [KO:K07377]
109687279  [KO:K06751]
109687282  [KO:K06751]
109687284  [KO:K06751]
109687287  [KO:K06751]
109687338  Cntnap1; contactin-associated protein 1 [KO:K07379]
109687645  Cd276; CD276 antigen isoform X1 [KO:K06746]
109687655  Neo1; LOW QUALITY PROTEIN: neogenin [KO:K06766]
109688602  Vcan; LOW QUALITY PROTEIN: versican core protein [KO:K06793]
109688616  Selplg; LOW QUALITY PROTEIN: P-selectin glycoprotein ligand 1 [KO:K06544]
109688682  Cldn2; claudin-2 [KO:K06087]
109688870  Cd99l2; LOW QUALITY PROTEIN: CD99 antigen-like protein 2 [KO:K06520]
109689087  Mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
109689092  Cdh4; cadherin-4 [KO:K06797]
109689100  Cd22; LOW QUALITY PROTEIN: B-cell receptor CD22 [KO:K06467]
109689143  Icoslg; ICOS ligand isoform X1 [KO:K06710]
109689153  Ptprm; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
109689261  Sdc4; syndecan-4 [KO:K16338]
109689299  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109690008  [KO:K06087]
109690011  [KO:K06087]
109690375  [KO:K06751]
109690377  [KO:K06751]
109690417  Mpz; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
109691200  Cldn19; claudin-19 [KO:K06087]
109691367  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
109691714  Cldn6; claudin-6 [KO:K06087]
109691716  Cldn9; claudin-9 [KO:K06087]
109691933  Sdc2; syndecan-2 [KO:K16336]
109692018  Ptprs; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
109692402  Nectin2; nectin-2 isoform X1 [KO:K06531]
109692409  [KO:K06539]
109692492  Cd2; T-cell surface antigen CD2 [KO:K06449]
109692493  Vtcn1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
109692731  Cdh15; cadherin-15 [KO:K06809]
109692819  Cldn15; claudin-15 [KO:K06087]
109693143  Nrxn3; neurexin 3 isoform X1 [KO:K07377]
109693172  Icam1; intercellular adhesion molecule 1 [KO:K06490]
109693178  Icam3; LOW QUALITY PROTEIN: intercellular adhesion molecule 3 [KO:K06486]
109693187  F11r; junctional adhesion molecule A [KO:K06089]
109693309  Cdh5; cadherin-5 [KO:K06533]
109693422  Cldn14; claudin-14 [KO:K06087]
109693763  Cdh1; cadherin-1 isoform X1 [KO:K05689]
109694003  Cd28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
109694333  Cd6; LOW QUALITY PROTEIN: T-cell differentiation antigen CD6 [KO:K06456]
109694534  Cd80; T-lymphocyte activation antigen CD80 [KO:K05412]
109694554  Siglec1; sialoadhesin isoform X1 [KO:K06548]
109694761  Sell; L-selectin [KO:K06495]
109694766  Selp; P-selectin isoform X1 [KO:K06496]
109694990  Itgb2; integrin beta-2 isoform X1 [KO:K06464]
109695178  [KO:K06752]
109695186  [KO:K06752]
109695196  [KO:K06752]
109695639  Pecam1; platelet endothelial cell adhesion molecule [KO:K06471]
109696349  Cldn12; claudin-12 [KO:K06087]
109696392  Jam2; junctional adhesion molecule B [KO:K06735]
109696521  [KO:K06461]
109697462  Cdh3; cadherin-3 [KO:K06796]
109697863  L1cam; neural cell adhesion molecule L1 [KO:K06550]
109697920  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
109698209  [KO:K06520]
109698765  Cldn10; LOW QUALITY PROTEIN: claudin-10 [KO:K06087]
109698805  Jam3; LOW QUALITY PROTEIN: junctional adhesion molecule C [KO:K06785]
109698815  Itga4; integrin alpha-4 isoform X1 [KO:K06483]
109699157  Cldn25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
109699310  Cadm3; cell adhesion molecule 3 isoform X1 [KO:K06780]
109699526  Cntn2; LOW QUALITY PROTEIN: contactin-2 [KO:K06760]
109699528  Nfasc; neurofascin isoform X1 [KO:K06757]
109699846  Tigit; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
109700044  Cldn20; claudin-20 [KO:K06087]
109700214  Cldn11; claudin-11 [KO:K06087]
109700591  Cd8b; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
109700610  Cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
109700667  Nectin3; nectin-3 isoform X1 [KO:K06592]
109700695  [KO:K06087]
109700866  Alcam; CD166 antigen isoform X1 [KO:K06547]
109700906  [KO:K06751]
109700950  Itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
109701399  Nrcam; neuronal cell adhesion molecule isoform X1 [KO:K06756]
109701536  Lrrc4; leucine-rich repeat-containing protein 4 isoform X1 [KO:K16351]
109702007  Cntn1; contactin-1 isoform X1 [KO:K06759]
109702039  [KO:K06464]
109702112  Cldn18; claudin-18 isoform X1 [KO:K06087]
109702226  Cadm1; cell adhesion molecule 1 isoform X1 [KO:K06781]
109702403  Slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]
109702433  Itgb8; integrin beta-8 [KO:K06591]
109702434  [KO:K06591]
109702827  [KO:K06087]
109702971  [KO:K06777] [EC:3.1.3.48]
109703180  Slitrk6; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 6 [KO:K25837]
109703244  Cdh2; cadherin-2 [KO:K06736]
109703328  Lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ccan04520  Adherens junction
ccan04530  Tight junction
ccan04610  Complement and coagulation cascades
ccan04660  T cell receptor signaling pathway
ccan04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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