KEGG   PATHWAY: ccan04530
Entry
ccan04530                   Pathway                                
Name
Tight junction - Castor canadensis (American beaver)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ccan04530  Tight junction
ccan04530

Other DBs
GO: 0005923
Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109674008  [KO:K06448]
109674010  [KO:K06448]
109674284  Cldn34; claudin-34 [KO:K06087]
109674577  Cldn7; claudin-7 [KO:K06087]
109674812  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109674943  [KO:K12757]
109675180  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
109675666  Was; wiskott-Aldrich syndrome protein [KO:K05747]
109676179  [KO:K12791]
109676269  Cldn8; claudin-8 [KO:K06087]
109676272  Cldn17; claudin-17 [KO:K06087]
109676493  [KO:K12757]
109676541  Cldn23; claudin-23 [KO:K06087]
109678843  [KO:K12075]
109678844  [KO:K12075]
109679300  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
109679330  [KO:K12757]
109680387  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
109680747  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
109680796  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
109680893  [KO:K21109]
109681174  Cgn; LOW QUALITY PROTEIN: cingulin [KO:K06102]
109681298  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
109681511  Llgl2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
109681639  Nf2; merlin isoform X1 [KO:K16684]
109682135  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
109683429  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
109683601  Amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
109683618  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
109683636  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
109683736  Arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
109683743  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
109683829  Cldn1; claudin-1 [KO:K06087]
109683834  Cldn16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
109683924  Myh14; myosin-14 [KO:K10352]
109684315  Cldn5; claudin-5 [KO:K06087]
109684369  [KO:K07374]
109684624  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
109684712  [KO:K04237]
109684714  [KO:K04237]
109684841  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
109684863  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
109685027  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
109685059  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
109685067  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
109685265  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
109685543  [KO:K10351]
109685688  [KO:K05762]
109685693  Rdx; radixin isoform X1 [KO:K05762]
109685696  Ocln; LOW QUALITY PROTEIN: occludin [KO:K06088]
109685697  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
109685993  [KO:K05699]
109686102  Myl6b; myosin light chain 6B [KO:K12751]
109686103  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
109686224  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109686409  [KO:K12757]
109686410  [KO:K12757]
109686728  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
109686738  [KO:K04440] [EC:2.7.11.24]
109686878  Myh11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
109686915  [KO:K06087]
109686941  [KO:K06087]
109686949  [KO:K06087]
109686996  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
109687131  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
109687258  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109687460  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
109687725  Amotl2; angiomotin-like protein 2 [KO:K06104]
109687790  Ppp2r1b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
109688040  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
109688047  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
109688382  Ezr; ezrin [KO:K08007]
109688682  Cldn2; claudin-2 [KO:K06087]
109688701  [KO:K04345] [EC:2.7.11.11]
109688706  [KO:K04345] [EC:2.7.11.11]
109688820  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
109689056  Rab8a; ras-related protein Rab-8A [KO:K07901]
109689106  [KO:K08018]
109689490  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109689563  [KO:K10352]
109689677  Tjp3; tight junction protein ZO-3 [KO:K06097]
109689908  [KO:K18050] [EC:2.7.11.13]
109689990  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
109690008  [KO:K06087]
109690011  [KO:K06087]
109690215  [KO:K07374]
109690217  Tuba1a; tubulin alpha-1A chain [KO:K07374]
109690218  [KO:K07374]
109690257  Sympk; LOW QUALITY PROTEIN: symplekin [KO:K06100]
109690263  [KO:K06100]
109690296  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
109690388  [KO:K04513]
109690402  [KO:K12757]
109690621  [KO:K08020]
109690802  Scrib; protein scribble homolog isoform X1 [KO:K16175]
109690907  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
109691016  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
109691074  Tuba4a; tubulin alpha-4A chain [KO:K07374]
109691200  Cldn19; claudin-19 [KO:K06087]
109691271  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
109691439  Prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
109691699  Micall2; MICAL-like protein 2 [KO:K21068]
109691714  Cldn6; claudin-6 [KO:K06087]
109691716  Cldn9; claudin-9 [KO:K06087]
109692163  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109692391  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
109692523  [KO:K06448]
109692819  Cldn15; claudin-15 [KO:K06087]
109692922  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109693187  F11r; junctional adhesion molecule A [KO:K06089]
109693422  Cldn14; claudin-14 [KO:K06087]
109693692  Pard6b; LOW QUALITY PROTEIN: partitioning defective 6 homolog beta [KO:K06093]
109693876  [KO:K06448]
109693877  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109693907  Myh10; myosin-10 isoform X1 [KO:K10352]
109694007  Arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
109694061  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
109694137  Epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
109694290  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
109694307  Crb3; protein crumbs homolog 3 [KO:K06090]
109694664  Cd1d; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
109694665  [KO:K18584]
109694818  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
109694921  Cdc42; cell division control protein 42 homolog [KO:K04393]
109695156  Rap1a; ras-related protein Rap-1A [KO:K04353]
109695531  Map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
109695664  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
109695677  Pcna; proliferating cell nuclear antigen [KO:K04802]
109695793  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
109695844  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
109696161  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
109696349  Cldn12; claudin-12 [KO:K06087]
109696351  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109696392  Jam2; junctional adhesion molecule B [KO:K06735]
109696411  Tjp2; LOW QUALITY PROTEIN: tight junction protein ZO-2 [KO:K06098]
109696610  Hspa4; LOW QUALITY PROTEIN: heat shock 70 kDa protein 4 [KO:K09489]
109696888  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
109697041  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
109697617  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
109697844  Rhoa; transforming protein RhoA [KO:K04513]
109697920  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
109697921  Bves; blood vessel epicardial substance isoform X1 [KO:K21108]
109698434  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
109698633  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
109698668  Rab8b; ras-related protein Rab-8B [KO:K07902]
109698765  Cldn10; LOW QUALITY PROTEIN: claudin-10 [KO:K06087]
109698805  Jam3; LOW QUALITY PROTEIN: junctional adhesion molecule C [KO:K06785]
109699157  Cldn25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
109699210  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
109699301  [KO:K18584]
109699358  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
109699478  Mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
109699863  Msn; moesin [KO:K05763]
109699995  [KO:K12076]
109700044  Cldn20; claudin-20 [KO:K06087]
109700050  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
109700175  [KO:K12755]
109700210  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
109700214  Cldn11; claudin-11 [KO:K06087]
109700271  Cttn; src substrate cortactin isoform X1 [KO:K06106]
109700400  Cgnl1; cingulin-like protein 1 [KO:K21110]
109700411  Runx1; runt-related transcription factor 1 [KO:K08367]
109700648  [KO:K07374]
109700662  [KO:K10591] [EC:2.3.2.26]
109700695  [KO:K06087]
109700700  [KO:K05692]
109700725  Mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
109700777  Jun; transcription factor AP-1 [KO:K04448]
109700897  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
109701160  Rap2c; ras-related protein Rap-2c isoform X1 [KO:K07839]
109702037  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
109702112  Cldn18; claudin-18 isoform X1 [KO:K06087]
109702150  [KO:K21112]
109702281  [KO:K05704] [EC:2.7.10.2]
109702827  [KO:K06087]
109703001  [KO:K06092]
109703004  [KO:K04440] [EC:2.7.11.24]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ccan04520  Adherens junction
ccan04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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