KEGG   PATHWAY: cgib00260
Entry
cgib00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Carassius gibelio (silver crucian carp)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cgib00260  Glycine, serine and threonine metabolism
cgib00260

Module
cgib_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cgib00260]
cgib_M00047  Creatine pathway [PATH:cgib00260]
cgib_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cgib00260]
cgib_M00621  Glycine cleavage system [PATH:cgib00260]
cgib_M00974  Betaine metabolism, animals, betaine => glycine [PATH:cgib00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127969548  uncharacterized protein LOC127969548 isoform X1 [KO:K01620] [EC:4.1.2.48]
128025422  uncharacterized protein LOC128025422 [KO:K01620] [EC:4.1.2.48]
127951928  serine hydroxymethyltransferase, cytosolic-like [KO:K00600] [EC:2.1.2.1]
127952410  serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
127959188  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
128016079  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
127951512  alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
127958980  alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128015550  alanine--glyoxylate aminotransferase-like isoform X1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
128027612  alanine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
127961884  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
127971002  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
127948760  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
128027504  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
127959993  glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
128015839  glycerate kinase-like [KO:K11529] [EC:2.7.1.165]
127970309  phosphoglycerate mutase 1a [KO:K01834] [EC:5.4.2.11]
127942069  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
127948608  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
127986178  phosphoglycerate mutase 2-like [KO:K01834] [EC:5.4.2.11]
128026116  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
128019824  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
127946682  bisphosphoglycerate mutase-like [KO:K01837] [EC:5.4.2.4 5.4.2.11]
128014707  bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
127964598  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
128020083  D-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
127958004  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
127990195  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
128029391  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
127951830  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
127945256  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
127983884  L-threonine dehydrogenase [KO:K15789] [EC:1.1.1.103]
127933472  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
127976036  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
127976316  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
127938547  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
127963004  5-aminolevulinate synthase, erythroid-specific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
127968282  5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
128022695  5-aminolevulinate synthase, non-specific, mitochondrial-like isoform X1 [KO:K00643] [EC:2.3.1.37]
128018730  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
127965135  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
128021321  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
128019948  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
127953595  retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
127950319  primary amine oxidase, liver isozyme-like [KO:K00276] [EC:1.4.3.21]
127957168  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
127997743  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
127963347  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
128018585  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
127947448  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
128014534  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
127962175  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
127934228  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
127977814  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
128016494  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
127958662  D-amino-acid oxidase-like isoform X1 [KO:K00273] [EC:1.4.3.3]
127958663  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
127958664  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
128012958  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
127942278  alanine--glyoxylate aminotransferase 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127986039  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
127934673  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
127977792  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
127968310  guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
127966182  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
127942096  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
127986306  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
127942093  dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
127972773  peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
127966273  sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
127975850  glycine N-methyltransferase isoform X1 [KO:K00552] [EC:2.1.1.20]
128031492  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
127965317  cystathionine beta-synthase b [KO:K01697] [EC:4.2.1.22]
127949645  cystathionine beta-synthase a [KO:K01697] [EC:4.2.1.22]
128015386  cystathionine beta-synthase-like protein [KO:K01697] [EC:4.2.1.22]
127959445  cystathionine gamma-lyase-like isoform X1 [KO:K01758] [EC:4.4.1.1]
128015702  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
128026629  L-threonine ammonia-lyase isoform X1 [KO:K01754] [EC:4.3.1.19]
127975941  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
127968199  zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cgib00010  Glycolysis / Gluconeogenesis
cgib00020  Citrate cycle (TCA cycle)
cgib00230  Purine metabolism
cgib00250  Alanine, aspartate and glutamate metabolism
cgib00270  Cysteine and methionine metabolism
cgib00290  Valine, leucine and isoleucine biosynthesis
cgib00330  Arginine and proline metabolism
cgib00470  D-Amino acid metabolism
cgib00564  Glycerophospholipid metabolism
cgib00600  Sphingolipid metabolism
cgib00620  Pyruvate metabolism
cgib00630  Glyoxylate and dicarboxylate metabolism
cgib00640  Propanoate metabolism
cgib00860  Porphyrin metabolism
cgib00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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