KEGG   PATHWAY: cmk00600
Entry
cmk00600                    Pathway                                
Name
Sphingolipid metabolism - Callorhinchus milii (elephant shark)
Class
Metabolism; Lipid metabolism
Pathway map
cmk00600  Sphingolipid metabolism
cmk00600

Module
cmk_M00066  Lactosylceramide biosynthesis [PATH:cmk00600]
cmk_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:cmk00600]
cmk_M00094  Ceramide biosynthesis [PATH:cmk00600]
cmk_M00099  Sphingosine biosynthesis [PATH:cmk00600]
Other DBs
GO: 0006665
Organism
Callorhinchus milii (elephant shark) [GN:cmk]
Gene
103177917  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
103182864  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
103186785  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
103183185  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
103181964  cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
103187682  cers3a; ceramide synthase 2 isoform X1 [KO:K24621] [EC:2.3.1.297]
103183569  ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
103176381  cers6; ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
103190303  ceramide synthase 6 isoform X1 [KO:K23727] [EC:2.3.1.291]
103172411  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
103178195  asah1b; acid ceramidase [KO:K12348] [EC:3.5.1.23]
103180876  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
103183483  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
103182854  acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
103190447  acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
103175334  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
103181614  degs1; sphingolipid delta(4)-desaturase DES1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
103180856  sgms1b; phosphatidylcholine:ceramide cholinephosphotransferase 1 [KO:K04714] [EC:2.7.8.27]
103187947  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
103189719  smpd2b; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
103183650  sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
103185923  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
103175461  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
103178834  zgc:153896; ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
103177038  cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
103179174  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
103182773  plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
103177820  plpp1a; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
103182070  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
103187548  phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
103185418  sgpp1b; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
103176344  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
103181428  sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
103187139  ugcg; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
103181004  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
103179660  b4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
103172840  beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
103183377  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
103181594  2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
103188741  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1 [KO:K04628] [EC:2.4.1.47]
121851509  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
103185410  galcb; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
103184338  gal3st1a; galactosylceramide sulfotransferase [KO:K01019] [EC:2.8.2.11]
103190820  arylsulfatase A [KO:K01134] [EC:3.1.6.8]
103182142  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
103187293  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
103187298  LOW QUALITY PROTEIN: sialidase-4-like [KO:K12357] [EC:3.2.1.18]
103189521  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
103189519  beta-1,4 N-acetylgalactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
103186366  hexb; beta-hexosaminidase subunit beta precursor [KO:K12373] [EC:3.2.1.52]
103184129  ganglioside GM2 activator [KO:K12383]
103184131  ganglioside GM2 activator-like [KO:K12383]
103185881  prosaposin [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
cmk00260  Glycine, serine and threonine metabolism
cmk00601  Glycosphingolipid biosynthesis - lacto and neolacto series
cmk00603  Glycosphingolipid biosynthesis - globo and isoglobo series
cmk00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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