KEGG   PATHWAY: cpea04514
Entry
cpea04514                   Pathway                                
Name
Cell adhesion molecules - Chaetura pelagica (chimney swift)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cpea04514  Cell adhesion molecules
cpea04514

Other DBs
GO: 0050839
Organism
Chaetura pelagica (chimney swift) [GN:cpea]
Gene
104384961  ALCAM; CD166 antigen [KO:K06547]
104385010  PVRL3; nectin-3 [KO:K06592]
104385020  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
104385235  [KO:K06751]
104385397  [KO:K06752]
104385453  NRXN3; neurexin 3 isoform X1 [KO:K07377]
104385566  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
104385694  CNTNAP1; LOW QUALITY PROTEIN: contactin-associated protein 1 [KO:K07379]
104386048  NEGR1; neuronal growth regulator 1 [KO:K06775]
104386085  PVRL1; nectin-1 [KO:K06081]
104386161  SIGLEC1; sialoadhesin [KO:K06548]
104386290  [KO:K23268]
104386360  ITGB8; integrin beta-8 [KO:K06591]
104386549  SDC3; syndecan-3 [KO:K16337]
104386550  [KO:K06752]
104386619  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
104386776  JAM2; junctional adhesion molecule B [KO:K06735]
104386778  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
104386932  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
104386953  CD226; LOW QUALITY PROTEIN: CD226 antigen [KO:K06567]
104387182  CLDN23; claudin-23 [KO:K06087]
104387241  [KO:K06087]
104387390  ITGA6; integrin alpha-6 [KO:K06485]
104387430  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
104387431  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
104387432  ICOS; inducible T-cell costimulator [KO:K06713]
104387553  ITGA4; integrin alpha-4 [KO:K06483]
104387707  CXADR; coxsackievirus and adenovirus receptor [KO:K06788]
104387741  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
104387854  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
104387938  [KO:K06087]
104388226  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
104388247  CLDN2; claudin-2 [KO:K06087]
104388251  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
104388252  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
104388348  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
104388385  CD40LG; CD40 ligand [KO:K03161]
104388474  CLDN20; claudin-20 [KO:K06087]
104388486  CADM3; cell adhesion molecule 3 [KO:K06780]
104388496  MPZ; myelin protein P0 [KO:K06770]
104388497  [KO:K06770]
104388541  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
104389104  [KO:K06087]
104389110  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
104389150  ICOSLG; ICOS ligand [KO:K06710]
104389290  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
104389342  GLG1; Golgi apparatus protein 1 [KO:K06816]
104389476  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
104389703  CDH4; cadherin-4 [KO:K06797]
104389750  SDC4; syndecan-4 [KO:K16338]
104389907  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
104389922  NTNG2; netrin-G2 [KO:K16359]
104389994  ITGA9; integrin alpha-9 [KO:K06585]
104390557  SELE; E-selectin [KO:K06494]
104390643  CLDN19; claudin-19 [KO:K06087]
104390645  [KO:K06087]
104390695  CLDN1; claudin-1 [KO:K06087]
104390704  CLDN16; claudin-16 [KO:K06087]
104390731  SELP; P-selectin [KO:K06496]
104390748  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
104391011  [KO:K06087]
104391051  CD8A; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
104391182  CLDN14; claudin-14 [KO:K06087]
104391191  PDCD1; programmed cell death protein 1 [KO:K06744]
104391383  [KO:K06745]
104391384  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
104391752  ITGB2; integrin beta-2 [KO:K06464]
104391838  XG; glycoprotein Xg [KO:K06520]
104391839  CD99; CD99 antigen [KO:K06520]
104392127  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
104392194  CLDN12; claudin-12 [KO:K06087]
104392420  [KO:K06087]
104392424  [KO:K06087]
104392658  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
104392956  SDC1; syndecan-1 [KO:K06257]
104393026  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
104393215  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
104393402  JAM3; junctional adhesion molecule C [KO:K06785]
104393975  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
104393976  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
104394072  ITGA8; integrin alpha-8 [KO:K06584]
104394563  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
104394980  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
104395286  NRXN1; neurexin-1-beta isoform X1 [KO:K07377]
104395771  [KO:K06449]
104395773  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
104395923  [KO:K06087]
104396103  NEO1; neogenin isoform X1 [KO:K06766]
104396124  CD276; CD276 antigen [KO:K06746]
104396345  CDH5; cadherin-5 [KO:K06533]
104396433  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
104396453  CNTN1; LOW QUALITY PROTEIN: contactin-1 [KO:K06759]
104396493  CLDN10; claudin-10 [KO:K06087]
104396515  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
104396655  SDC2; syndecan-2 [KO:K16336]
104396709  PTPRF; receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
104396745  CLDN11; claudin-11 [KO:K06087]
104396777  NTNG1; netrin-G1 [KO:K07522]
104396952  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
104396988  CDH2; cadherin-2 [KO:K06736]
104397060  ITGB1; integrin beta-1 [KO:K05719]
104397307  [KO:K07380]
104397834  CLDN18; claudin-18 isoform X1 [KO:K06087]
104398071  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
104398168  OCLN; occludin [KO:K06088]
104398241  NFASC; neurofascin isoform X1 [KO:K06757]
104398249  [KO:K06760]
104398359  CDH1; cadherin-1 [KO:K05689]
104398360  CDH3; cadherin-3 [KO:K06796]
104398787  CADM1; cell adhesion molecule 1 [KO:K06781]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
cpea04520  Adherens junction
cpea04530  Tight junction
KO pathway
ko04514   

DBGET integrated database retrieval system