KEGG   PATHWAY: csyr04137
Entry
csyr04137                   Pathway                                
Name
Mitophagy - animal - Carlito syrichta (Philippine tarsier)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
csyr04137  Mitophagy - animal
csyr04137

Other DBs
GO: 0000422
Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103249716  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
103249727  MTX3; metaxin-3 isoform X2 [KO:K17776]
103249780  RRAS; ras-related protein R-Ras [KO:K07829]
103250079  RHOT2; mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103250149  MTX2; metaxin-2 isoform X1 [KO:K17776]
103250595  [KO:K04551]
103250683  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
103250903  FIS1; mitochondrial fission 1 protein [KO:K17969]
103251125  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial [KO:K15637] [EC:3.1.3.16]
103251244  HUWE1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
103251501  MTX1; metaxin-1 isoform X1 [KO:K17776]
103251513  OPA1; dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
103251560  RHOT1; mitochondrial Rho GTPase 1 isoform X4 [KO:K07870] [EC:3.6.5.-]
103251734  MRAS; ras-related protein M-Ras [KO:K07831]
103251851  FKBP8; peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1 [KO:K09574] [EC:5.2.1.8]
103251854  UBA52; ubiquitin-60S ribosomal protein L40 isoform X1 [KO:K02927]
103251997  TOMM20; mitochondrial import receptor subunit TOM20 homolog isoform X1 [KO:K17770]
103252019  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103252077  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
103252103  RELA; transcription factor p65 [KO:K04735]
103252211  PHB2; prohibitin-2 [KO:K17081]
103252253  FUNDC1; FUN14 domain-containing protein 1 [KO:K17986]
103252280  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103252426  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103253070  MON1B; vacuolar fusion protein MON1 homolog B isoform X1 [KO:K20195]
103253158  AMFR; E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
103253965  E2F1; transcription factor E2F1 [KO:K17454]
103254373  [KO:K15464]
103254791  MUL1; mitochondrial ubiquitin ligase activator of NFKB 1 [KO:K15688] [EC:2.3.2.27]
103254798  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
103254926  SAMM50; sorting and assembly machinery component 50 homolog [KO:K07277]
103255312  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103256046  RAB7B; ras-related protein Rab-7b [KO:K07898]
103256203  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
103256896  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
103257541  TBC1D15; TBC1 domain family member 15 isoform X2 [KO:K20168]
103257904  USP15; ubiquitin carboxyl-terminal hydrolase 15 [KO:K21343] [EC:3.4.19.12]
103257915  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
103258094  TBC1D17; TBC1 domain family member 17 [KO:K19945]
103258896  CITED2; cbp/p300-interacting transactivator 2 [KO:K21361]
103259032  TOMM20L; TOMM20-like protein 1 [KO:K17770]
103259236  NRAS; GTPase NRas [KO:K07828]
103260226  [KO:K04684]
103260257  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X2 [KO:K11518]
103260325  RABGEF1; rab5 GDP/GTP exchange factor isoform X1 [KO:K20131]
103260745  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X2 [KO:K11839] [EC:3.4.19.12]
103261242  ATG9A; autophagy-related protein 9A isoform X2 [KO:K17907]
103262114  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103262806  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
103263176  BNIP3L; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2 [KO:K15465]
103263234  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
103263304  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103263740  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
103264516  MARCH5; E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
103264637  TP53; cellular tumor antigen p53 [KO:K04451]
103264735  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X2 [KO:K21348]
103264885  TFEB; transcription factor EB isoform X1 [KO:K15590]
103264907  UBB; polyubiquitin-B [KO:K04551]
103264913  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103265323  FOXO3; forkhead box protein O3 [KO:K09408]
103265523  MON1A; LOW QUALITY PROTEIN: vacuolar fusion protein MON1 homolog A [KO:K20195]
103265752  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
103266415  RAB5B; ras-related protein Rab-5B isoform X3 [KO:K07888]
103267309  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X2 [KO:K04374]
103267783  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
103267878  NBR1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
103268716  TFE3; transcription factor E3 [KO:K09105]
103269587  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103269634  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
103269958  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
103270159  CSNK2B; casein kinase II subunit beta isoform X3 [KO:K03115]
103270391  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
103270410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103270494  CSNK2A2; casein kinase II subunit alpha' isoform X2 [KO:K03097] [EC:2.7.11.1]
103270690  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
103270696  BECN1; beclin-1 isoform X1 [KO:K08334]
103270722  NLRX1; NLR family member X1 [KO:K12653]
103270946  [KO:K15464]
103271669  TOMM70; mitochondrial import receptor subunit TOM70 [KO:K17768]
103271901  [KO:K11851] [EC:3.4.19.12]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103272809  OPTN; optineurin isoform X1 [KO:K19946]
103272922  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
103272968  MAPK8; mitogen-activated protein kinase 8 isoform X5 [KO:K04440] [EC:2.7.11.24]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103274018  [KO:K02927]
103274230  BCL2L13; bcl-2-like protein 13 isoform X1 [KO:K15485]
103274470  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103274529  JUN; transcription factor AP-1 [KO:K04448]
103275058  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
103275300  ATG9B; autophagy-related protein 9B [KO:K17907]
103275496  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
103275501  ARIH1; E3 ubiquitin-protein ligase ARIH1 [KO:K11968] [EC:2.3.2.31]
103275507  CCZ1; vacuolar fusion protein CCZ1 homolog [KO:K27045]
103276258  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X2 [KO:K08341]
103276762  RAB5C; ras-related protein Rab-5C isoform X2 [KO:K07889]
110594692  [KO:K02927]
110596262  [KO:K02977]
110596390  TOMM7; mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
csyr04140  Autophagy - animal
csyr04210  Apoptosis
KO pathway
ko04137   

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